Chou, Tsui-Fen

Article from CaltechAUTHORS

• Tan, Chieh-Hsiang and Wang, Ting-Yu, et el. (2024) Single-tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organelles; Proceedings of the National Academy of Sciences; Vol. 121; No. 25; 10.1073/pnas.2322588121
• Pang, Marion and Jones, Jeff J., et el. (2024) Increasing Proteome Coverage Through a Reduction in Analyte Complexity in Single-Cell Equivalent Samples; Journal of Proteome Research; 10.1021/acs.jproteome.4c00062
• Lo, Yu-Li and Li, Ching-Yao, et el. (2024) Exploring in vivo combinatorial chemo-immunotherapy: Addressing p97 suppression and immune reinvigoration in pancreatic cancer with tumor microenvironment-responsive nanoformulation; Biomedicine & Pharmacotherapy; Vol. 175; 116660; 10.1016/j.biopha.2024.116660
• Wallach, Izhar and Bernard, Denzil, et el. (2024) AI is a viable alternative to high throughput screening: a 318-target study; Scientific Reports; Vol. 14; 7526; 10.1038/s41598-024-54655-z
• Li, Ching-Yao and Chou, Tsui-Fen, et el. (2024) An innovative nanoformulation utilizing tumor microenvironment-responsive PEG-polyglutamic coating and dynamic charge adjustment for specific targeting of ER stress inducer, microRNA, and immunoadjuvant in pancreatic cancer: In vitro investigations; International Journal of Biological Macromolecules; Vol. 254; No. Pt. 2; 127905; 10.1016/j.ijbiomac.2023.127905
• Mah-Som, Annelise Y. and Daw, Jil, et el. (2023) An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP; American Journal of Human Genetics; Vol. 110; No. 11; 1959-1975; PMCID PMC10645565
• Godneeva, Baira and Fejes Toth, Katalin, et el. (2023) Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries; Cells; Vol. 12; No. 22; 2629; PMCID PMC10670193; 10.3390/cells12222629
• Mohanty, Atish and Nam, Arin, et el. (2023) Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer; Science Advances; Vol. 9; No. 41; eade3816; PMCID PMC10575592; 10.1126/sciadv.ade3816
• Schiava, Marianela and Ikenaga, Chiseko, et el. (2023) Clinical Classification of Variants in the Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy; Neurology Genetics; Vol. 9; No. 5; e200093; 10.1212/nxg.0000000000200093
• Tu, Jiaobing and Min, Jihong, et el. (2023) A wireless patch for the monitoring of C-reactive protein in sweat; Nature Biomedical Engineering; Vol. 7; No. 10; 1293-1306; PMCID PMC10592261; 10.1038/s41551-023-01059-5
• Luzzi, Anna and Wang, Feng, et el. (2023) Skeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations; Frontiers in Neurology; Vol. 14; 1211635; PMCID PMC10435852
• LaPorte, Matthew G. and Alverez, Celeste, et el. (2023) Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer; ACS Medicinal Chemistry Letters; Vol. 14; No. 7; 977-985; PMCID PMC10351062; 10.1021/acsmedchemlett.3c00163
• Findlay, Andrew R. and Paing, May M., et el. (2023) DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1; Molecular Therapy - Nucleic Acids; Vol. 32; 937-948; PMCID PMC10280091; 10.1016/j.omtn.2023.05.017
• Jones, Jeff and MacKrell, Elliot J., et el. (2023) Tidyproteomics: an open-source R package and data object for quantitative proteomics post analysis and visualization; BMC Bioinformatics; Vol. 24; Art. No. 239; PMCID PMC10246047; 10.1186/s12859-023-05360-7
• Dutka, Przemysław and Metskas, Lauren Ann, et el. (2023) Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET; Structure; Vol. 31; No. 5; 518-528; PMCID PMC10185304; 10.1016/j.str.2023.03.011
• Le Guerroué, François and Bunker, Eric N., et el. (2023) TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1; Molecular Cell; Vol. 83; No. 6; 927-941.e8; PMCID PMC10112281; 10.1016/j.molcel.2023.02.023
• Guna, Alina and Stevens, Taylor A., et el. (2022) MTCH2 is a mitochondrial outer membrane protein insertase; Science; Vol. 378; No. 6617; 317-322; PMCID PMC9674023; 10.1126/science.add1856
• Puskar, Ryan and Du Truong, Chloe, et el. (2022) Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria; Nature Communications; Vol. 13; Art. No. 5824; PMCID PMC9529944; 10.1038/s41467-022-33505-4
• LeBlanc, Amy K. and Mazcko, Christina N., et el. (2022) Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs; Molecular Cancer Therapeutics; Vol. 21; No. 10; 1510-1523; PMCID PMC9538592; 10.1158/1535-7163.mct-22-0167
• Spero, Melanie A. and Jones, Jeff, et el. (2022) Mechanisms of chlorate toxicity and resistance in Pseudomonas aeruginosa; Molecular Microbiology; Vol. 118; No. 4; 321-335; PMCID PMC9589919; 10.1111/mmi.14972
• Ravanfar, Raheleh and Sheng, Yuling, et el. (2022) Surface cysteines could protect the SARS-CoV-2 main protease from oxidative damage; Journal of Inorganic Biochemistry; Vol. 234; Art. No. 111886; PMCID PMC9161685; 10.1016/j.jinorgbio.2022.111886
• Yang, Chien-I and Zhu, Zikun, et el. (2022) System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity; iScience; Vol. 25; No. 8; Art. No. 104756; PMCID PMC9356101; 10.1016/j.isci.2022.104756
• Wang, F. and Li, S., et el. (2022) P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration; Brain Communications; Vol. 4; No. 4; Art. No. fcac176; PMCID PMC9294923; 10.1093/braincomms/fcac176
• Wang, Feng and Li, Shan, et el. (2022) Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells; ChemMedChem; Vol. 17; No. 11; Art. No. e202200030; 10.1002/cmdc.202200030
• Zhang, Gang and Wang, Feng, et el. (2022) Discovery of small-molecule inhibitors of RUVBL1/2 ATPase; Bioorganic and Medicinal Chemistry; Vol. 62; Art. No. 116726; PMCID PMC9034851; 10.1016/j.bmc.2022.116726
• Li, Shan and Wang, Feng, et el. (2022) NMS-873 Leads to Dysfunctional Glycometabolism in A p97-Independent Manner in HCT116 Colon Cancer Cells; Pharmaceutics; Vol. 14; No. 4; 764; PMCID PMC9024726; 10.3390/pharmaceutics14040764
• Wang, Feng and Li, Shan, et el. (2022) Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition; Cell Chemical Biology; Vol. 29; No. 3; 517-529; PMCID PMC8934257; 10.1016/j.chembiol.2021.11.005
• Nandi, Purbasha and Li, Shan, et el. (2022) Mechanism of the alteration in domain-domain communications in human p97/VCP atpase; Biophysical Journal; Vol. 121; No. 3; 298a; 10.1016/j.bpj.2021.11.1259
• Wang, Feng and Li, Shan, et el. (2022) The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation; Pharmaceuticals; Vol. 15; No. 2; Art. No. 204; PMCID PMC8880557; 10.3390/ph15020204
• Phan, Quynh T. and Lin, Jianfeng, et el. (2021) The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection; mBio; Vol. 12; No. 6; Art. No. e02716-21; PMCID PMC8561387; 10.1128/mBio.02716-21
• Cheng, Kai-Wen and Li, Shan, et el. (2021) Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication; Cells; Vol. 10; No. 11; Art. No. 2953; PMCID PMC8616207; 10.3390/cells10112953
• Zhang, Xiaoyi and Gui, Lin, et el. (2021) Conserved L464 in p97 D1–D2 linker is critical for p97 cofactor regulated ATPase activity; Biochemical Journal; Vol. 478; No. 17; 3185-3204; PMCID PMC9041309; 10.1042/bcj20210288
• Michels, Dana E. and Lomenick, Brett, et el. (2021) Amino Acid Analog Induces Stress Response in Marine Synechococcus; Applied and Environmental Microbiology; Vol. 87; No. 15; Art. No. e00200-21; 10.1128/aem.00200-21
• Nandi, Purbasha and Li, Shan, et el. (2021) Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes; International Journal of Molecular Sciences; Vol. 22; No. 15; Art. No. 8079; PMCID PMC8347982; 10.3390/ijms22158079
• Wani, Abubakar and Zhu, Jiang, et el. (2021) Neuronal VCP loss of function recapitulates FTLD-TDP pathology; Cell Reports; Vol. 36; No. 3; Art. No. 109399; PMCID PMC8383344; 10.1016/j.celrep.2021.109399
• Zhang, Gang and Li, Shan, et el. (2021) AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors; European Journal of Medicinal Chemistry; Vol. 219; Art. No. 113446; PMCID PMC8165034; 10.1016/j.ejmech.2021.113446
• Yang, Xiaohong and Yang, Xiaoxiao, et el. (2021) A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides; AMB Express; Vol. 11; Art. No. 94; PMCID PMC8225759; 10.1186/s13568-021-01253-1
• Cheng, Kai-Wen and Wang, Feng, et el. (2021) Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells; Biochemical Journal; Vol. 478; No. 12; 2309-2319; PMCID PMC9074758; 10.1042/bcj20210015
• Zhang, Gang and Li, Shan, et el. (2021) A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells; European Journal of Medicinal Chemistry; Vol. 213; Art. No. 113148; PMCID PMC7954469; 10.1016/j.ejmech.2020.113148
• Wang, Feng and Moen, Derek R., et el. (2021) Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human α-N-Acetylglucosamine-6-Sulfatase in Neonatal Mice; Molecular Pharmaceutics; Vol. 18; No. 1; 214-227; PMCID PMC8362844; 10.1021/acs.molpharmaceut.0c00831
• Chen, Yu-Chuan and Navarrete, Marian S., et el. (2020) N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells; Scientific Reports; Vol. 10; Art. No. 11952; 10.1038/s41598-020-68615-w
• Wang, Feng and Li, Shan, et el. (2020) Allosteric p97 inhibitors can overcome resistance to ATP-competitive p97 inhibitors for potential anti-cancer therapy; ChemMedChem; Vol. 15; No. 8; 685-694; PMCID PMC9049325; 10.1002/cmdc.201900722
• Li, Jing and Zhang, Yaru, et el. (2018) Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11; Cell Chemical Biology; Vol. 25; No. 11; 1350-1358; PMCID PMC6309308; 10.1016/j.chembiol.2018.07.012
• LaPorte, Matthew G. and Burnett, James C., et el. (2018) Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97; ACS Medicinal Chemistry Letters; Vol. 9; No. 11; 1075-1081; PMCID PMC6231190; 10.1021/acsmedchemlett.8b00372
• Sanghez, Valentina and Chen, Mengqing, et el. (2018) Efficacy of Asparaginase Erwinia chrysanthemi With and Without Temozolomide Against Glioma Cells and Intracranial Mouse Medulloblastoma; Anticancer Research; Vol. 38; No. 5; 2627-2634; 10.21873/anticanres.12504
• Nakasone, Mark A. and Lewis, Timothy A., et el. (2017) Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway; Structure; Vol. 25; No. 12; 1839-1855; 10.1016/j.str.2017.10.007
• Bastola, Prabhakar and Wang, Feng, et el. (2017) Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors; Cell Death Discovery; Vol. 3; Art. No. 17065; PMCID PMC5672561; 10.1038/cddiscovery.2017.65
• Sanghez, Valentina and Luzzi, Anna, et el. (2017) Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation; PLoS ONE; Vol. 12; No. 10; Art. No. e0186818; PMCID PMC5658089; 10.1371/journal.pone.0186818
• Shah, Rachit and Chou, Tsui-Fen, et el. (2017) Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain; Biochemical and Biophysical Research Communications; Vol. 491; No. 3; 760-766; 10.1016/j.bbrc.2017.07.111
• Lee, YouJin and Chou, Tsui-Fen, et el. (2017) Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination; Cell Reports; Vol. 19; No. 1; 188-202; PMCID PMC5395095; 10.1016/j.celrep.2017.03.030
• Segura-Cabrera, Aldo and Tripathi, Reshmi, et el. (2017) A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase; Scientific Reports; Vol. 7; Art. No. 44912; PMCID PMC5359624; 10.1038/srep44912
• Perez, Christian and Li, Jing, et el. (2017) Discovery of an Inhibitor of the Proteasome Subunit Rpn11; Journal of Medicinal Chemistry; Vol. 60; No. 4; 1343-1361; PMCID PMC5761724; 10.1021/acs.jmedchem.6b01379
• Bulfer, Stacie L. and Chou, Tsui-Fen, et el. (2016) p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions; ACS Chemical Biology; Vol. 11; No. 8; 2112-2116; PMCID PMC5224236; 10.1021/acschembio.6b00350
• Gui, Lin and Zhang, Xiaoyi, et el. (2016) Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes; ChemMedChem; Vol. 11; No. 9; 953-957; 10.1002/cmdc.201600036
• Liu, Mingfu and Lin, Lin, et el. (2015) Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine; PLOS Pathogens; Vol. 11; No. 5; Art. No. e1004842; PMCID PMC4431732; 10.1371/journal.ppat.1004842
• Zhang, Xiaoyi and Gui, Lin, et el. (2015) Altered cofactor regulation with disease-associated p97/VCP mutations; Proceedings of the National Academy of Sciences of the United States of America; Vol. 112; No. 14; E1705-E1714; PMCID PMC4394316; 10.1073/pnas.1418820112
• Weihl, Conrad C. and Baloh, Robert H., et el. (2015) Targeted sequencing and identification of genetic variants in sporadic inclusion body myositis; Neuromuscular Disorders; Vol. 25; No. 4; 289-296; 10.1016/j.nmd.2014.12.009
• Jerath, Nivedita U. and Crockett, Cameron D., et el. (2015) Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation; Case Reports in Genetics; Vol. 2015; Art. No. 239167; PMCID PMC4386706; 10.1155/2015/239167
• Fang, Chen-Jie and Gui, Lin, et el. (2015) Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97-p47 Complex; ChemMedChem; Vol. 10; No. 1; 52-56; PMCID PMC4280364; 10.1002/cmdc.201402420
• Kato, Mihoko and Chou, Tsui-Fen, et el. (2014) LINKIN, a new transmembrane protein necessary for cell adhesion; eLife; Vol. 2014; No. 3; Art. No. e04449; PMCID PMC4275582; 10.7554/eLife.04449
• Gonzalez, Michael A. and Feely, Shawna M., et el. (2014) A novel mutation in VCP causes Charcot–Marie–Tooth Type 2 disease; Brain; Vol. 137; No. 11; 2897-2902; PMCID PMC4208462; 10.1093/brain/awu224
• Sapir, Amir and Tsur, Assaf, et el. (2014) Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 37; E3880-E3889; PMCID PMC4169931; 10.1073/pnas.1414748111
• Chou, Tsui-Fen and Bulfer, Stacie L., et el. (2014) Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains; Journal of Molecular Biology; Vol. 426; No. 15; 2886-2899; PMCID PMC4102644; 10.1016/j.jmb.2014.05.022
• Deshaies, Raymond and Chou, Tsui-Fen, et el. (2014) Exploiting protein homeostasis for cancer therapy; FASEB Journal; Vol. 28; No. 1; 472.2
• Zhou, Xin and Chou, Tsui-Fen, et el. (2013) Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1; Biochemistry; Vol. 52; No. 20; 3588-3600; PMCID PMC3835729; 10.1021/bi301616c
• Shi, Yihui and Liu, Xiaohe, et el. (2013) Development of functional assays for p97/VCP inhibition; Cancer Research; Vol. 73; No. 8; Art. No. 2146; 10.1158/1538-7445.AM2013-2146
• Chou, Tsui-Fen and Li, Kelin, et el. (2013) Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase; ChemMedChem; Vol. 8; No. 2; 297-312; PMCID PMC3662613; 10.1002/cmdc.201200520
• Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Development of p97 AAA ATPase inhibitors; Autophagy; Vol. 7; No. 9; 1091-1092; PMCID PMC3210319; 10.4161/auto.7.9.16489
• Bardaweel, Sanaa and Ghosh, Brahma, et el. (2011) E. coli Histidine Triad Nucleotide Binding Protein 1 (ecHinT) Is a Catalytic Regulator of D-Alanine Dehydrogenase (DadA) Activity In Vivo; PLoS ONE; Vol. 6; No. 7; Art. No. e20897; PMCID PMC3130732; 10.1371/journal.pone.0020897
• Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System; Journal of Biological Chemistry; Vol. 286; No. 19; 16546-16554; PMCID PMC3089497; 10.1074/jbc.M110.215319
• Birkus, Gabriel and Kutty, Nilima, et el. (2011) Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191; Antimicrobial Agents and Chemotherapy; Vol. 55; No. 5; 2166-2173; PMCID PMC3088193; 10.1128/aac.01603-10
• Chou, Tsui-Fen and Brown, Steve J., et el. (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proceedings of the National Academy of Sciences of the United States of America; Vol. 108; No. 12; 4834-4839; PMCID PMC3064330; 10.1073/pnas.1015312108
• Bardaweel, Sanaa and Pace, James, et el. (2010) Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis; Journal of Molecular Biology; Vol. 404; No. 4; 627-638; 10.1016/j.jmb.2010.09.066
• Cheng, Jilin and Zhou, Xin, et el. (2009) Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection; Bioorganic and Medicinal Chemistry Letters; Vol. 19; No. 22; 6379-6381; 10.1016/j.bmcl.2009.09.067
• Chou, Tsui-Fen and So, Christopher, et el. (2008) Enzyme Nanorings; ACS Nano; Vol. 2; No. 12; 2519-2525; PMCID PMC2682639; 10.1021/nn800577h
• Ghosh, Phalguni and Cheng, Jilin, et el. (2008) Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein; Protein Expression and Purification; Vol. 60; No. 2; 132-139; PMCID PMC2617730; 10.1016/j.pep.2008.03.024
• Chou, Tsui-Fen and Sham, Yuk Y., et el. (2007) Impact of the C-Terminal Loop of Histidine Triad Nucleotide Binding Protein1 (Hint1) on Substrate Specificity; Biochemistry; Vol. 46; No. 45; 13074-13079; 10.1021/bi701244h
• Chou, Tsui-Fen and Cheng, Jilin, et el. (2007) Evidence that Human Histidine Triad Nucleotide Binding Protein 3 (Hint3) is a Distinct Branch of the Histidine Triad (HIT) Superfamily; Journal of Molecular Biology; Vol. 373; No. 4; 978-989; 10.1016/j.jmb.2007.08.023
• Chou, Tsui-Fen and Tikh, Ilya B., et el. (2007) Engineered Monomeric Human Histidine Triad Nucleotide-binding Protein 1 Hydrolyzes Fluorogenic Acyl-adenylate and Lysyl-tRNA Synthetase-generated Lysyl-adenylate; Journal of Biological Chemistry; Vol. 282; No. 20; 15137-15147; 10.1074/jbc.m606972200
• Chou, Tsui-Fen and Baraniak, Janina, et el. (2007) Phosphoramidate Pronucleotides:  A Comparison of the Phosphoramidase Substrate Specificity of Human and Escherichia coli Histidine Triad Nucleotide Binding Proteins; Molecular Pharmaceutics; Vol. 4; No. 2; 208-217; 10.1021/mp060070y
• Chou, Tsui-Fen and Wagner, Carston R. (2007) Lysyl-tRNA Synthetase-generated Lysyl-Adenylate Is a Substrate for Histidine Triad Nucleotide Binding Proteins; Journal of Biological Chemistry; Vol. 282; No. 7; 4719-4727; 10.1074/jbc.m610530200
• Carlson, Jonathan C. T. and Jena, Sidhartha S., et el. (2006) Chemically Controlled Self-Assembly of Protein Nanorings; Journal of the American Chemical Society; Vol. 128; No. 23; 7630-7638; 10.1021/ja060631e
• Kim, Jisook and Chou, Tsui-fen, et el. (2004) Direct Measurement of Nucleoside Monophosphate Delivery from a Phosphoramidate Pronucleotide by Stable Isotope Labeling and LC−ESI⁻-MS/MS; Molecular Pharmaceutics; Vol. 1; No. 2; 102-111; 10.1021/mp0340338