Dervan, Peter

Article from CaltechAUTHORS

• Dervan, Peter B. (2022) Skydiving into the interface of chemistry and biology; Chemical & Engineering News; Vol. 100; No. 10; 36-40
• Oh, Juntaek and Jia, Tiezheng, et el. (2022) RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder; Proceedings of the National Academy of Sciences of the United States of America; Vol. 119; No. 3; Art. No. e2114065119; PMCID PMC8784135; 10.1073/pnas.2114065119
• Finn, Paul B. and Bhimsaria, Devesh, et el. (2020) Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome; PLoS ONE; Vol. 15; No. 12; Art. No. e0243905; 10.1371/journal.pone.0243905
• Chen, Chien-yu and Li, Yang, et el. (2020) Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides; Medicinal Chemistry Research; Vol. 29; No. 4; 607-616; PMCID PMC8455084; 10.1007/s00044-019-02493-4
• Kurmis, Alexis A. and Dervan, Peter B. (2019) Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide; Nucleic Acids Research; Vol. 47; No. 8; 3828-3835; PMCID PMC6486638; 10.1093/nar/gkz153
• Dervan, Peter B. (2019) A Personal Perspective on Chemical Biology: Before the Beginning; Israel Journal of Chemistry; Vol. 59; No. 1-2; 71-83; 10.1002/ijch.201800171
• Dervan, Peter B. (2019) Ronald Breslow Award for Achievement in Biomimetic Chemistry: David A. Tirrell; Chemical and Engineering News; Vol. 97; No. 3; 51
• Diaz-Perez, S. and Kane, N., et el. (2018) Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair; International Journal of Radiation Oncology Biology Physics; Vol. 102; No. 3, Supp.; e155; 10.1016/j.ijrobp.2018.07.604
• Houk, K. N. and Caserio, Marjorie C., et el. (2018) J. D. Roberts Special Issue; Journal of Physical Organic Chemistry; Vol. 31; No. 8; Art. No. e3886; 10.1002/poc.3886
• Diaz-Perez, Silvia and Kane, Nathanael, et el. (2018) Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide; PLoS ONE; Vol. 13; No. 5; Art. No. e0196803; PMCID PMC5929528; 10.1371/journal.pone.0196803
• Dervan, Peter B. (2018) Herbert C. Brown Award for Creative Research in Synthetic Methods: Gregory C. Fu; Chemical and Engineering News; Vol. 96; No. 2; 40
• Xu, Jun and Lahiri, Indrajit, et el. (2017) Structural basis for the initiation of eukaryotic transcription-coupled DNA repair; Nature; Vol. 551; No. 7682; 653-657; PMCID PMC5907806; 10.1038/nature24658
• Kurmis, Alexis A. and Yang, Fei, et el. (2017) A pyrrole-imidazole polyamide is active against enzalutamide-resistant prostate cancer; Cancer Research; Vol. 77; No. 9; 2207-2212; 10.1158/0008-5472.CAN-16-2503
• Xu, Liang and Wang, Wei, et el. (2016) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif; Proceedings of the National Academy of Sciences of the United States of America; Vol. 113; No. 44; 12426-12431; PMCID PMC5098678; 10.1073/pnas.1612745113
• Dervan, Peter B. (2016) Ahmed H. Zewail (1946-2016); Science; Vol. 353; No. 6304; 1103-1103; 10.1126/science.aai8466
• Gerhardt, Jeannine and Bhalla, Angela D., et el. (2016) Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells; Cell Reports; Vol. 16; No. 5; 1218-1227; PMCID PMC5028224; 10.1016/j.celrep.2016.06.075
• Szablowski, Jerzy O. and Raskatov, Jevgenij A., et el. (2016) An HRE-binding Py-Im polyamide impairs hypoxic signaling in tumors; Molecular Cancer Therapeutics; Vol. 15; No. 4; 608-617; PMCID PMC4873353; 10.1158/1535-7163.MCT-15-0719
• Mysore, Veena S. and Szablowski, Jerzy, et el. (2016) A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma has Potent Anti-tumor Activity; Molecular Cancer Research; Vol. 14; No. 3; 253-266; PMCID PMC4794370; 10.1158/1541-7786.MCR-15-0361
• Hargrove, Amanda E. and Martínez, Thomas F., et el. (2015) Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide; PLoS ONE; Vol. 10; No. 11; Art. No. e0143161; PMCID PMC4646452; 10.1371/journal.pone.0143161
• Kummer, N. T. and Yang, F., et el. (2015) Radiosensitization by DNA, Binding Pyrrole, Imidazole Polyamides; International Journal of Radiation Oncology Biology Physics; Vol. 93; No. 3, Supp. 1; E537-E538; 10.1016/j.ijrobp.2015.07.1923
• Kang, JeenJoo S. and Dervan, Peter B. (2015) A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma; Quarterly Reviews of Biophysics; Vol. 48; No. 4; 453-464; PMCID PMC4743504; 10.1017/S0033583515000104
• Kummer, N. T. and Yang, F., et el. (2015) DNA Repair Interference with Sequence Specific DNA Binding Pyrrole Imidazole Polyamides; a Novel Radiation Sensitizer; Strahlentherapie und Onkologie; Vol. 191; No. 11; 902-903; 10.1007/s00066-015-0903-6
• Raskatov, Jevgenij A. and Szablowski, Jerzy O., et el. (2014) Tumor Xenograft Uptake of a Pyrrole−Imidazole (Py-Im) Polyamide Varies as a Function of Cell Line Grafted; Journal of Medicinal Chemistry; Vol. 57; No. 20; 8471-8476; PMCID PMC4207538; 10.1021/jm500964c
• Martínez, Thomas F. and Philips, John W., et el. (2014) Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response; Nucleic Acids Research; Vol. 42; No. 18; 11546-11559; PMCID PMC4191428; 10.1093/nar/gku866
• Mysore, Veena S. and Nickols, Nicholas G., et el. (2014) Targeting hypoxia-mediated gene transcription with a novel polyamide drug designed to disrupt the HIF1α/β heterodimer binding overcomes resistance to hypoxia in myeloma cell lines; Cancer Research; Vol. 74; No. 19 Suppleme; Art. No. 5132; 10.1158/1538-7445.AM2014-5132
• Raskatov, Jevgenij A. and Puckett, James W., et el. (2014) A C-14 labeled Py–Im polyamide localizes to a subcutaneous prostate cancer tumor; Bioorganic and Medicinal Chemistry; Vol. 22; No. 16; 4371-4375; PMCID PMC4134956; 10.1016/j.bmc.2014.04.010
• Kang, JeenJoo S. and Meier, Jordan L., et el. (2014) Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition; Journal of the American Chemical Society; Vol. 136; No. 9; 3687-3694; PMCID PMC3985849; 10.1021/ja500211z
• Nickols, N. and Yang, F., et el. (2013) Radiosensitization by High Affinity Programmable Minor Groove Binders; International Journal of Radiation Oncology Biology Physics; Vol. 87; No. S2; S651-S652; 10.1016/j.ijrobp.2013.06.1725
• Yang, Fei and Nickols, Nicholas G., et el. (2013) Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit; Journal of Medicinal Chemistry; Vol. 56; No. 18; 7449-7457; PMCID PMC3788622; 10.1021/jm401100s
• Nickols, Nicholas G. and Szablowski, Jerzy O., et el. (2013) Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element; Molecular Cancer Therapeutics; Vol. 12; No. 5; 675-684; PMCID PMC3651785; 10.1158/1535-7163.MCT-12-1040
• Nickols, Nicholas G. and Yang, Fei, et el. (2013) Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models; Cancer Research; Vol. 73; No. 8; Art. No. 1130; 10.1158/1538-7445.AM2013-1130
• Edwards, Jonathan S. and Betts, Laurie, et el. (2013) Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 8; 2804-2809; PMCID PMC3581901; 10.1073/pnas.1219701110
• Yang, Fei and Nickols, Nicholas G., et el. (2013) Antitumor activity of a pyrrole-imidazole polyamide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 110; No. 5; 1863-1868; PMCID PMC3562772; 10.1073/pnas.1222035110
• Li, Benjamin C. and Montgomery, David C., et el. (2013) Synthesis of Cyclic Py-Im Polyamide Libraries; Journal of Organic Chemistry; Vol. 78; No. 1; 124-133; PMCID PMC3538502; 10.1021/jo302053v
• Chenoweth, David M. and Meier, Jordan L., et el. (2013) Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA; Angewandte Chemie International Edition; Vol. 52; No. 1; 415-418; PMCID PMC3535541; 10.1002/anie.201205775
• Meier, Jordan L. and Yu, Abigail S., et el. (2012) Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing; Journal of the American Chemical Society; Vol. 134; No. 42; 17814-17822; PMCID PMC3483022; 10.1021/ja308888c
• Raskatov, Jevgenij A. and Nickols, Nicholas G., et el. (2012) Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 40; 16041-16045; PMCID PMC3479560; 10.1073/pnas.1214267109
• Synold, Timothy W. and Xi, Bixin, et el. (2012) Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice; Cancer Chemotherapy and Pharmacology; Vol. 70; No. 4; 617-625; PMCID PMC3456924; 10.1007/s00280-012-1954-3
• Du, Jintang and Campau, Erica, et el. (2012) Role of Mismatch Repair Enzymes in GAA•TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells; Journal of Biological Chemistry; Vol. 287; No. 35; 29861-29872; PMCID PMC3436184; 10.1074/jbc.M112.391961
• Jespersen, Christine and Soragni, Elisabetta, et el. (2012) Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells; Bioorganic and Medicinal Chemistry Letters; Vol. 22; No. 12; 4068-4071; PMCID PMC3362666; 10.1016/j.bmcl.2012.04.090
• Hargrove, Amanda E. and Raskatov, Jevgenij A., et el. (2012) Characterization and Solubilization of Pyrrole−Imidazole Polyamide Aggregates; Journal of Medicinal Chemistry; Vol. 55; No. 11; 5425-5432; PMCID PMC3375050; 10.1021/jm300380a
• Puckett, James W. and Green, Joshua T., et el. (2012) Microwave Assisted Synthesis of Py-Im Polyamides; Organic Letters; Vol. 14; No. 11; 2774-2777; PMCID PMC3365540; 10.1021/ol3010003
• Raskatov, Jevgenij A. and Hargrove, Amanda E., et el. (2012) Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear; Journal of the American Chemical Society; Vol. 134; No. 18; 7995-7999; PMCID PMC3349014; 10.1021/ja302588v
• Meier, Jordan L. and Montgomery, David C., et el. (2012) Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns; Nucleic Acids Research; Vol. 40; No. 5; 2345-2356; PMCID PMC3300022; 10.1093/nar/gkr970
• Raskatov, Jevgenij A. and Meier, Jordan L., et el. (2012) Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 4; 1023-1028; PMCID PMC3268328; 10.1073/pnas.1118506109
• Zhang, Yi and Sicot, Géraldine, et el. (2011) Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole−Imidazole Polyamide; Biochemistry; Vol. 50; No. 48; 10431-10441; PMCID PMC3619939; 10.1021/bi200962u
• Muzikar, Katy A. and Meier, Jordan L., et el. (2011) Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA; Organic Letters; Vol. 13; No. 20; 5612-5615; PMCID PMC3195311; 10.1021/ol202285y
• Chenoweth, David M. and Dervan, Peter B. (2010) Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding; Journal of the American Chemical Society; Vol. 132; No. 41; 14521-14529; PMCID PMC2954530; 10.1021/ja105068b
• Jacobs, Claire S. and Dervan, Peter B. (2009) Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture; Journal of Medicinal Chemistry; Vol. 52; No. 23; 7380-7388; PMCID PMC2788682; 10.1021/jm900256f
• Muzikar, Katy A. and Nickols, Nicholas G., et el. (2009) Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 39; 16598-16603; PMCID PMC2744631; 10.1073/pnas.0909192106
• Chenoweth, David M. and Harki, Daniel A., et el. (2009) Oligomerization Route to Py-Im Polyamide Macrocycles; Organic Letters; Vol. 11; No. 16; 3590-3593; PMCID PMC2736337; 10.1021/ol901311m
• Chenoweth, David M. and Dervan, Peter B. (2009) Allosteric modulation of DNA by small molecules; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 32; 13175-13179; PMCID PMC2726366; 10.1073/pnas.0906532106
• Farkas, Michelle E. and Li, Benjamin C., et el. (2009) DNA sequence selectivity of hairpin polyamide turn units; Bioorganic and Medicinal Chemistry Letters; Vol. 19; No. 14; 3919-3923; PMCID PMC3062503; 10.1016/j.bmcl.2009.03.072
• Ho, Dominik and Dose, Christian, et el. (2009) Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray; Biophysical Journal; Vol. 96; No. 11; 4661-4671; PMCID PMC2711479; 10.1016/j.bpj.2009.02.059
• Chenoweth, David M. and Harki, Daniel A., et el. (2009) Solution-phase synthesis of pyrrole-imidazole polyamides; Journal of the American Chemical Society; Vol. 131; No. 20; 7175-7181; PMCID PMC2689157; 10.1021/ja901307m
• Chenoweth, David M. and Harki, Daniel A., et el. (2009) Cyclic pyrrole-imidazole polyamides targeted to the androgen response element; Journal of the American Chemical Society; Vol. 131; No. 20; 7182-7188; PMCID PMC2689155; 10.1021/ja901309z
• Sicot, Géraldine and Vogel, Marion, et el. (2008) Development of a novel polyamide-based agent to inhibit EVI1 function; Blood; Vol. 112; No. 11; 920
• Hsu, Carey F. and Dervan, Peter B. (2008) Quantitating the concentration of Py-Im polyamide–fluorescein conjugates in live cells; Bioorganic and Medicinal Chemistry Letters; Vol. 18; No. 22; 5851-5855; PMCID PMC2587135; 10.1016/j.bmcl.2008.05.063
• Hsu, Carey F. and Dervan, Peter B. (2008) Quantitating the Concentration of Polyamide-Fluorescein Conjugates in Live Cells; Bioorganic Medicinal Chemistry Letters Online; Vol. 18; No. 22; 5851-5; 10.1016/j.bmcl.2008.05.063
• Harki, Daniel A. and Satyamurthy, Nagichettiar, et el. (2008) In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography; Proceedings of the National Academy of Sciences of the United States of America; Vol. 105; No. 35; 13039-13044; PMCID PMC2529060; 10.1073/pnas.0806308105
• Dose, Christian and Farkas, Michelle E., et el. (2008) Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit; Journal of the American Chemical Society; Vol. 130; No. 21; 6859-6866; PMCID PMC3063708; 10.1021/ja800888d
• Moretti, Rocco and Donato, Leslie J., et el. (2008) Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly; ACS Chemical Biology; Vol. 3; No. 4; 220-229; PMCID PMC3060767; 10.1021/cb700258r
• Chou, C. James and Farkas, Michelle E., et el. (2008) Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia; Molecular Cancer Therapeutics; Vol. 7; No. 4; 769-778; PMCID PMC2376757; 10.1158/1535-7163.MCT-08-0130
• Cohen, Justin D. and Sadowski, John P., et el. (2008) Programming multiple protein patterns on a single DNA nanostructure; Journal of the American Chemical Society; Vol. 130; No. 2; 402-403; 10.1021/ja0772400
• Farkas, Michelle E. and Tsai, Sherry M., et el. (2007) α-Diaminobutyric acid-linked hairpin polyamides; Bioorganic and Medicinal Chemistry; Vol. 15; No. 22; 6927-6936; PMCID PMC2140246; 10.1016/j.bmc.2007.07.019
• Stafford, Ryan L. and Dervan, Peter B. (2007) The reach of linear protein-DNA dimerizers; Journal of the American Chemical Society; Vol. 129; No. 45; 14026-14033; PMCID PMC2547995; 10.1021/ja075247b
• Dose, Christian and Ho, Dominik, et el. (2007) Recognition of "mirror-image" DNA by small molecules; Angewandte Chemie International Edition; Vol. 46; No. 44; 8384-8387; 10.1002/anie.200703007
• Cohen, Justin D. and Sadowski, John P., et el. (2007) Addressing single molecules on DNA nanostructures; Angewandte Chemie International Edition; Vol. 46; No. 42; 7956-1959; 10.1002/anie.200702767
• Puckett, James W. and Muzikar, Katy A., et el. (2007) Quantitative microarray profiling of DNA-binding molecules; Journal of the American Chemical Society; Vol. 129; No. 40; 12310-12319; PMCID PMC3066056; 10.1021/ja0744899
• Nickols, Nicholas G. and Jacobs, Claire S., et el. (2007) Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface; ACS Chemical Biology; Vol. 2; No. 8; 561-571; PMCID PMC3060759; 10.1021/cb700110z
• Hsu, Carey F. and Phillips, John W., et el. (2007) Completion of a Programmable DNA-Binding Small Molecule Library; Tetrahedron; Vol. 63; No. 27; 6146-6151; PMCID PMC2151752; 10.1016/j.tet.2007.03.041
• Nickols, Nicholas G. and Dervan, Peter B. (2007) Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 25; 10418-10423; PMCID PMC1965528; 10.1073/pnas.0704217104
• Stafford, Ryan L. and Arndt, Hans-Dieter, et el. (2007) Minimization of a Protein−DNA Dimerizer; Journal of the American Chemical Society; Vol. 129; No. 9; 2660-2668; PMCID PMC3064071; 10.1021/ja067971k
• Chenoweth, David M. and Viger, Anne, et el. (2007) Fluorescent Sequence-Specific dsDNA Binding Oligomers; Journal of the American Chemical Society; Vol. 129; No. 8; 2216-2217; PMCID PMC3066654; 10.1021/ja0682576
• Chenoweth, David M. and Poposki, Julie A., et el. (2007) Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition; Bioorganic and Medicinal Chemistry; Vol. 15; No. 2; 759-770; PMCID PMC3208330; 10.1016/j.bmc.2006.10.051
• Tsai, Sherry M. and Farkas, Michelle E., et el. (2007) Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates; Nucleic Acids Research; Vol. 35; No. 1; 307-316; PMCID PMC1802559; 10.1093/nar/gkl1025
• Nickols, Nicholas G. and Jacobs, Claire S., et el. (2007) Improved nuclear localization of DNA-binding polyamides; Nucleic Acids Research; Vol. 35; No. 2; 363-370; PMCID PMC1802595; 10.1093/nar/gkl1042
• Viger, Anne and Dervan, Peter B. (2006) Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site; Bioorganic and Medicinal Chemistry; Vol. 14; No. 24; 8539-8549; 10.1016/j.bmc.2006.08.028
• Burnett, Ryan and Melander, Christian, et el. (2006) DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxia; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 31; 11497-11502; PMCID PMC1544198; 10.1073/pnas.0604939103
• Doss, Raymond M. and Marques, Michael A., et el. (2006) Programmable oligomers for minor groove DNA recognition; Journal of the American Chemical Society; Vol. 128; No. 28; 9074-9079; PMCID PMC2547997; 10.1021/ja0621795
• Alvarez, David and Chou, C. James, et el. (2006) A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate; Cell Cycle; Vol. 5; No. 14; 1537-1548; 10.4161/cc.5.14.2913
• Warren, Christopher L. and Kratochvil, Natasha C. S., et el. (2006) Defining the sequence-recognition profile of DNA-binding molecules; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 4; 867-872; PMCID PMC1347994; 10.1073/pnas.0509843102
• Fechter, Eric J. and Olenyuk, Bogdan, et el. (2005) Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates; Journal of the American Chemical Society; Vol. 127; No. 47; 16685-16691; 10.1021/ja054650k
• Dervan, Peter B. and Doss, Raymond M., et el. (2005) Programmable DNA binding oligomers for control of transcription; Current Medicinal Chemistry Anticancer Agents; Vol. 5; No. 4; 373-387; 10.2174/1568011054222346
• Hauschild, Karl E. and Metzler, Renee E., et el. (2005) Temperature-sensitive protein–DNA dimerizers; Proceedings of the National Academy of Sciences of the United States of America; Vol. 102; No. 14; 5008-5013; PMCID PMC555971; 10.1073/pnas.0501289102
• Gearhart, Micah D. and Dickinson, Liliane, et el. (2005) Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides; Biochemistry; Vol. 44; No. 11; 4196-4203; 10.1021/bi047872o
• Philips, Brian J. and Chang, Aileen Y., et el. (2005) DNA damage effects of a polyamide-CBI conjugate in SV40 virions; Molecular Pharmacology; Vol. 67; No. 3; 877-882; 10.1124/mol.104.006254
• Edayathumangalam, Rajeswari S. and Weyermann, Philipp, et el. (2005) Nucleosomes in solution exist as a mixture of twist-defect states; Journal of Molecular Biology; Vol. 345; No. 1; 103-114; 10.1016/j.jmb.2004.10.012
• Kwon, Youngjoo and Arndt, Hans-Dieter, et el. (2004) Small molecule transcription factor mimic; Journal of the American Chemical Society; Vol. 126; No. 49; 15940-15941; 10.1021/ja0445140
• Olenyuk, Bogdan Z. and Zhang, Guo-Jun, et el. (2004) Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 48; 16768-16773; PMCID PMC534742; 10.1073/pnas.0407617101
• Dickinson, Liliane A. and Burnett, Ryan, et el. (2004) Arresting cancer proliferation by small-molecule gene regulation; Chemistry and Biology; Vol. 11; No. 11; 1583-1594; 10.1016/j.chembiol.2004.09.004
• Ylisastigui, Loyda and Coull, Jason J., et el. (2004) Polyamides Reveal a Role for Repression in Latency within Resting T Cells of HIV-Infected Donors; Journal of Infectious Diseases; Vol. 190; No. 8; 1429-1437; 10.1086/423822
• Livengood, Jill A. and Fechter, Eric J., et el. (2004) Paradoxical effects of DNA binding polyamides on HTLV-1 transcription; Frontiers in Bioscience; Vol. 9; 3058-3067; 10.2741/1459
• Marques, Michael A. and Doss, Raymond M., et el. (2004) Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition; Journal of the American Chemical Society; Vol. 126; No. 33; 10339-10349; 10.1021/ja0486465
• Fechter, Eric J. and Olenyuk, Bogdan, et el. (2004) Design of a sequence-specific DNA bisintercalator; Angewandte Chemie International Edition; Vol. 43; No. 27; 3591-3594; 10.1002/anie.200454231
• Zhang, Qing and Dwyer, Tammy J., et el. (2004) NMR structure of a cyclic polyamide-DNA complex; Journal of the American Chemical Society; Vol. 126; No. 25; 7958-7966; 10.1021/ja0373622
• Rucker, Victor C. and Dunn, Alexander R., et el. (2004) Mechanism of Sequence-Specific Fluorescent Detection of DNA by N-Methyl-imidazole, N-Methyl-pyrrole, and β-Alanine Linked Polyamides; Journal of Physical Chemistry B; Vol. 108; No. 22; 7490-7494; 10.1021/jp037423i
• Doss, Raymond M. and Marques, Michael A., et el. (2004) DNA minor-groove recognition by 3-methylthiophene/pyrrole pair; Chemistry and Biodiversity; Vol. 1; No. 6; 886-899; 10.1002/cbdv.200490071
• Edayathumangalam, Rajeswari S. and Weyermann, Philipp, et el. (2004) Molecular recognition of the nucleosomal "supergroove"; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 18; 6864-6869; PMCID PMC406433; 10.1073/pnas.0401743101
• Edelson, Benjamin S. and Best, Timothy P., et el. (2004) Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates; Nucleic Acids Research; Vol. 32; No. 9; 2802-2818; PMCID PMC419610; 10.1093/nar/gkh609
• Nguyen-Hackley, Doan H. and Ramm, Elizabeth, et el. (2004) Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands; Biochemistry; Vol. 43; No. 13; 3880-3890; 10.1021/bi030223c
• Poulin-Kerstien, Adam T. and Dervan, Peter B. (2003) DNA-templated dimerization of hairpin polyamides; Journal of the American Chemical Society; Vol. 125; No. 51; 15811-21; 10.1021/ja030494a
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• Geierstanger, Bernhard H. and Mrksich, Milan, et el. (1996) Extending the recognition site of designed minor groove binding molecules; Nature Structural Biology; Vol. 3; No. 4; 321-324; 10.1038/nsb0496-321
• Cho, Junhyeong and Parks, Michelle E., et el. (1995) Cyclic polyamides for recognition in the minor groove of DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 22; 10389-10392; PMCID PMC40802
• Baliga, Ramesh and Singleton, Jennifer W., et el. (1995) RecA•oligonucleotide filaments bind in the minor groove of double-stranded DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 22; 10393-10397; PMCID PMC40803
• Baliga, Ramesh and Singleton, Jennifer W., et el. (1995) RecA·Oligonucleotide Filaments Bind in the Minor Groove of Double-Stranded DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 22; 10393-10397; PMCID PMC40803
• Chen, Lin and Oakley, Martha G., et el. (1995) Only one of the two DNA-bound orientations of AP-1 found in solution cooperates with NFATp; Current Biology; Vol. 5; No. 8; 882-889; 10.1016/S0960-9822(95)00178-3
• Greenberg, William A. and Dervan, Peter B. (1995) Energetics of Formation of Sixteen Triple Helical Complexes Which Vary at a Single Position Within a Purine Motif; Journal of the American Chemical Society; Vol. 117; No. 18; 5016-5022; 10.1021/ja00123a002
• Colocci, Natalia and Dervan, Peter B. (1995) Cooperative Triple-Helix Formation at Adjacent DNA Sites: Sequence Composition Dependence at the Junction; Journal of the American Chemical Society; Vol. 117; No. 17; 4781-4787; 10.1021/ja00122a007
• Priestley, E. Scott and Dervan, Peter B. (1995) Sequence Composition Effects on the Energetics of Triple Helix Formation by Oligonucleotides Containing a Designed Mimic of Protonated Cytosine; Journal of the American Chemical Society; Vol. 117; No. 17; 4761-4765; 10.1021/ja00122a004
• Hunziker, Jürg and Priestley, E. Scott, et el. (1995) Design of an N^7-Glycosylated Purine Nucleoside for Recognition of GC Base Pairs by Triple Helix Formation; Journal of the American Chemical Society; Vol. 117; No. 9; 2661-2662; 10.1021/ja00114a036
• Mrksich, Milan and Dervan, Peter B. (1995) Recognition in the Minor Groove of DNA at 5'-(A,T)GCGC(A,T)-3' by a Four Ring Tripeptide Dimer. Reversal of the Specificity of the Natural Product Distamycin; Journal of the American Chemical Society; Vol. 117; No. 12; 3325-3332; 10.1021/ja00117a002
• Best, George C. and Dervan, Peter B. (1995) Energetics of Formation of Sixteen Triple Helical Complexes Which Vary at a Single Position within a Pyrimidine Motif; Journal of the American Chemical Society; Vol. 117; No. 4; 1187-1193; 10.1021/ja00109a001
• Singleton, Scott F. and Dervan, Peter B. (1994) Temperature Dependence of the Energetics of Oligonucleotide-Directed Triple-Helix Formation at a Single DNA Site; Journal of the American Chemical Society; Vol. 116; No. 23; 10376-10382; 10.1021/ja00102a003
• Geierstanger, Bernhard H. and Mrksich, Milan, et el. (1994) Design of a G•C-Specific DNA Minor Groove-Binding Peptide; Science; Vol. 266; No. 5185; 646-650; 10.1126/science.7939719
• Khundkar, Lutfur R. and Perry, Joseph W., et el. (1994) Weak Temperature Dependence of Electron Transfer Rates in Fixed-Distance Porphyrin-Quinone Model Systems; Journal of the American Chemical Society; Vol. 116; No. 21; 9700-9709; 10.1021/ja00100a040
• Mrksich, Milan and Parks, Michell E., et el. (1994) Hairpin Peptide Motif. A New Class of Oligopeptides for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA; Journal of the American Chemical Society; Vol. 116; No. 18; 7983-7988; 10.1021/ja00097a004
• Han, Hogyu and Schepartz, Alanna, et el. (1994) Mapping RNA Regions in Eukaryotic Ribosomes That Are Accessible to Methidiumpropyl-EDTA•Fe(II) and EDTA•Fe(II); Biochemistry; Vol. 33; No. 33; 9831-9844
• Han, Hogyu and Dervan, Peter B. (1994) Different conformational families of pyrimidine·purine·pyrimidine triple helices depending on backbone composition; Nucleic Acids Research; Vol. 22; No. 14; 2837-2844; PMCID PMC308255; 10.1093/nar/22.14.2837
• Staubli, Andrea B. and Dervan, Peter B. (1994) Sequence specificity of the non-natural pyrido[2,3-d]pyrimidine nucleoside in triple helix formation; Nucleic Acids Research; Vol. 22; No. 13; 2637-2642; PMCID PMC308221; 10.1093/nar/22.13.2637
• Hacia, Joseph G. and Dervan, Peter B., et el. (1994) Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation; Biochemistry; Vol. 33; No. 20; 6192-6200; 10.1021/bi00186a019
• Han, Hogyu and Dervan, Peter B. (1994) Visualization of RNA tertiary struture by RNA-EDTA·Fe(II) autocleavage: Analysis of tRNAPhe with uridine-EDTA·Fe(II) at position 47; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 11; 4955-4959; PMCID PMC43908
• Hacia, Joseph G. and Wold, Barbara J., et el. (1994) Phosphorothioate oligonucleotide-directed triple helix formation; Biochemistry; Vol. 33; No. 18; 5367-5369; 10.1021/bi00184a002
• Oakley, Martha G. and Turnbull, Kenneth D., et el. (1994) Synthesis of a hybrid protein containing the iron-binding ligand of bleomycin and the DNA-binding domain of Hin; Bioconjugate Chemistry; Vol. 5; No. 3; 242-247; 10.1021/bc00027a009
• Mrksich, Milan and Dervan, Peter B. (1994) Design of a Covalent Peptide Heterodimer for Sequence-Specific Recognition in the Minor Groove of Double-Helical DNA; Journal of the American Chemical Society; Vol. 116; No. 8; 3663-3664; 10.1021/ja00087a088
• Geierstanger, Bernhard H. and Jacobsen, Jens Peter, et el. (1994) Structural and dynamic characterization of the heterodimeric and homodimeric complexes of distamycin and 1-methylimidazole-2-carboxamide-netropsin bound to the minor groove of DNA; Biochemistry; Vol. 33; No. 10; 3055-3062; 10.1021/bi00176a039
• Colocci, Natalia and Dervan, Peter B. (1994) Cooperative Binding of 8-mer Oligonucleotides Containing 5-(1-Propynyl)-2'-deoxyuridine to Adjacent DNA Sites by Triple-Helix Formation; Journal of the American Chemical Society; Vol. 116; No. 2; 785-786; 10.1021/ja00081a056
• Singleton, Scott F. and Dervan, Peter B. (1993) Equilibrium association constants for oligonucleotide-directed triple helix formation at single DNA sites: linkage to cation valence and concentration; Biochemistry; Vol. 32; No. 48; 13171-13179; 10.1021/bi00211a028
• Dwyer, Tammy J. and Geierstanger, Bernhard H., et el. (1993) Structural analysis of covalent peptide dimers, bis(pyridine-2-carboxamidonetropsin)(CH_2)_(3-6), in complex with 5'-TGACT-3' sites by two-dimensional NMR; Journal of the American Chemical Society; Vol. 115; No. 22; 9900-9906; 10.1021/ja00075a005
• Mrksich, Milan and Dervan, Peter B. (1993) Enhanced sequence specific recognition in the minor groove of DNA by covalent peptide dimers: bis(pyridine-2-carboxamidonetropsin)(CH_2)_(3-6); Journal of the American Chemical Society; Vol. 115; No. 22; 9892-9899; 10.1021/ja00075a004
• Radhakrishnan, Ishwar and Patel, Dinshaw J., et el. (1993) NMR structural studies on a nonnatural deoxyribonucleoside which mediates recognition of GC base pairs in pyrimidine•purine•pyrimidine DNA triplexes; Biochemistry; Vol. 32; No. 41; 11228-11234; 10.1021/bi00092a037
• Koshlap, Karl M. and Gillespie, Paul, et el. (1993) Nonnatural deoxyribonucleoside D_3 incorporated in an intramolecular DNA triplex binds sequence-specifically by intercalation; Journal of the American Chemical Society; Vol. 115; No. 17; 7908-7909; 10.1021/ja00070a059
• Feng, Jin-An and Simon, Melvin, et el. (1993) Crystallization and preliminary X-ray analysis of the DNA binding domain of the Hin recombinase with its DNA binding site; Journal of Molecular Biology; Vol. 232; No. 3; 982-986; 10.1006/jmbi.1993.1443
• Tor, Yitzhak and Dervan, Peter B. (1993) Site-specific enzymic incorporation of an unnatural base, N^6-(6-aminohexyl)isoguanosine, into RNA; Journal of the American Chemical Society; Vol. 115; No. 11; 4461-4467; 10.1021/ja00064a007
• Colocci, Natalia and Distefano, Mark D., et el. (1993) Cooperative oligonucleotide-directed triple helix formation at adjacent DNA sites; Journal of the American Chemical Society; Vol. 115; No. 11; 4468-4473; 10.1021/ja00064a008
• Han, Hogyu and Dervan, Peter B. (1993) Sequence-specific recognition of double helical RNA and RNA·DNA by triple helix formation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 9; 3806-3810; PMCID PMC46394; 10.1073/pnas.90.9.3806
• Mrksich, Milan and Dervan, Peter B. (1993) Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by a distamycin/1-methylimidazole-2-carboxamide-netropsin pair; Journal of the American Chemical Society; Vol. 115; No. 7; 2572-2576; 10.1021/ja00060a004
• MacDonald, Marcy E. and Strobel, Scott A., et el. (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes; Cell; Vol. 72; No. 6; 971-83; 10.1016/0092-8674(93)90585-E
• Stilz, Hans Ulrich and Dervan, Peter B. (1993) Specific recognition of CG base pairs by 2-deoxynebularine within the purine•purine•pyrimidine triple-helix motif; Biochemistry; Vol. 32; No. 9; 2177-85; 10.1021/bi00060a008
• Distefano, Mark D. and Dervan, Peter B. (1993) Energetics of Cooperative Binding of Oligonucleotides with Discrete Dimerization Domains to DNA by Triple Helix Formation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 90; No. 4; 1179-1183; PMCID PMC45836; 10.1073/pnas.90.4.1179
• Distefano, Mark D. and Dervan, Peter B. (1992) Ligand-promoted dimerization of oligonucleotides binding cooperatively to DNA; Journal of the American Chemical Society; Vol. 114; No. 27; 11006-11007; 10.1021/ja00053a073
• Oakley, Martha G. and Mrksich, Milan, et el. (1992) Evidence that a minor groove-binding peptide and a major groove-binding protein can simultaneously occupy a common site on DNA; Biochemistry; Vol. 31; No. 45; 10969-10975; 10.1021/bi00160a005
• Wade, Warren S. and Mrksich, Milan, et el. (1992) Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif; Journal of the American Chemical Society; Vol. 114; No. 23; 8783-8794; 10.1021/ja00049a006
• Singleton, Scott F. and Dervan, Peter B. (1992) Influence of pH on the equilibrium association constants for oligodeoxyribonucleotide-directed triple helix formation at single DNA sites; Biochemistry; Vol. 31; No. 45; 10995-11003; 10.1021/bi00160a008
• Griffin, Linda C. and Kiessling, Laura L., et el. (1992) Recognition of all four base pairs of double-helical DNA by triple-helix formation: design of nonnatural deoxyribonucleosides for pyrimidine•purine base pair binding; Journal of the American Chemical Society; Vol. 114; No. 21; 7976-7982; 10.1021/ja00047a003
• Mack, David P. and Dervan, Peter B. (1992) Sequence-specific oxidative cleavage of DNA by a designed metalloprotein, nickel(II)•GGH(Hin139-190); Biochemistry; Vol. 31; No. 39; 9399-405; 10.1021/bi00154a011
• Dervan, Peter B. (1992) Reagents for the site-specific cleavage of megabase DNA; Nature; Vol. 359; No. 6390; 87-88; 10.1038/359087a0
• Singleton, Scott F. and Dervan, Peter B. (1992) Thermodynamics of oligodeoxyribonucleotide-directed triple helix formation: an analysis using quantitative affinity cleavage titration; Journal of the American Chemical Society; Vol. 114; No. 18; 6957-6965; 10.1021/ja00044a002
• Mrksich, Milan and Wade, Warren S., et el. (1992) Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2 carboxamide netropsin; Proceedings of the National Academy of Sciences of the United States of America; Vol. 89; No. 16; 7586-7590; PMCID PMC49755; 10.1073/pnas.89.16.7586
• Povsic, Thomas J. and Strobel, Scott A., et el. (1992) Sequence-specific double-strand alkylation and cleavage of DNA mediated by triple-helix formation; Journal of the American Chemical Society; Vol. 114; No. 15; 5934-5941; 10.1021/ja00041a005
• Luebke, Kevin J. and Dervan, Peter B. (1992) Nonenymatic ligation of double-helical DNA by alternate-strand triple helix formation; Nucleic Acids Research; Vol. 20; No. 12; 3005-3009; PMCID PMC312430; 10.1093/nar/20.12.3005
• Beal, Peter A. and Dervan, Peter B. (1992) Recognition of double helical DNA by alternate strand triple helix formation; Journal of the American Chemical Society; Vol. 114; No. 13; 4976-4982; 10.1021/ja00039a004
• Beal, Peter A. and Dervan, Peter B. (1992) The influence of single base triplet changes on the stability of a Pur·Pur·Pyr triple helix determined by affinity cleaving; Nucleic Acids Research; Vol. 20; No. 11; 2773-2776; PMCID PMC336921; 10.1093/nar/20.11.2773
• Kiessling, Laura L. and Griffin, Linda C., et el. (1992) Flanking sequence effects within the pyrimidine triple-helix motif characterized by affinity cleaving; Biochemistry; Vol. 31; No. 10; 2829-2834; 10.1021/bi00125a026
• Koh, Jong Sung and Dervan, Peter B. (1992) Design of a nonnatural deoxyribonucleoside for recognition of GC base pairs by oligonucleotide-directed triple helix formation; Journal of the American Chemical Society; Vol. 114; No. 4; 1470-1478; 10.1021/ja00030a050
• Maher, L. James, III and Dervan, Peter B., et el. (1992) Analysis of promoter-specific repression by triple-helical DNA complexes in a eukaryotic cell-free transcription system; Biochemistry; Vol. 31; No. 1; 70-81; 10.1021/bi00116a012
• Strobel, Scott A. and Doucette-Stamm, Lynn A., et el. (1991) Site-specific cleavage of human chromosome 4 mediated by triple-helix formation; Science; Vol. 254; No. 5038; 1639-1642; 10.1126/science.1836279
• Shin, Jumi A. and Ebright, Richard H., et el. (1991) Orientation of the Lac repressor DNA binding domain in complex with the left lac operator half site characterized by affinity cleaving; Nucleic Acids Research; Vol. 19; No. 19; 5233-5236; PMCID PMC328881; 10.1093/nar/19.19.5233
• Horne, David A. and Dervan, Peter B. (1991) Effects of an abasic site on triple helix formation characterized by affinity cleaving; Nucleic Acids Research; Vol. 19; No. 18; 4963-4965; PMCID PMC328797; 10.1093/nar/19.18.4963
• Luebke, Kevin J. and Dervan, Peter B. (1991) Nonenzymic sequence-specific ligation of double-helical DNA; Journal of the American Chemical Society; Vol. 113; No. 19; 7447-7448; 10.1021/ja00019a066
• Distefano, Mark D. and Shin, Jumi A., et el. (1991) Cooperative binding of oligonucleotides to DNA by triple helix formation: dimerization via Watson-Crick hydrogen bonds; Journal of the American Chemical Society; Vol. 113; No. 15; 5901-5902; 10.1021/ja00015a076
• Beal, Peter A. and Dervan, Peter B. (1991) Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation; Science; Vol. 251; No. 4999; 1360-1363; 10.1126/science.2003222
• Strobel, Scott A. and Dervan, Peter B. (1991) Single-site enzymatic cleavage of yeast genomic DNA mediated by triple helix formation; Nature; Vol. 350; No. 6314; 172-174; 10.1038/350172a0
• Povsic, Thomas J. and Dervan, Peter B. (1990) Sequence-specific alkylation of double-helical DNA by oligonucleotide-directed triple-helix formation; Journal of the American Chemical Society; Vol. 112; No. 25; 9428-9430; 10.1021/ja00181a075
• Plum, G. Eric and Park, Young-Whan, et el. (1990) Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: A spectroscopic and calorimetric study; Proceedings of the National Academy of Sciences of the United States of America; Vol. 87; No. 23; 9436-9440; PMCID PMC55180; 10.1073/pnas.87.23.9436
• Häner, Robert and Dervan, Peter B. (1990) Single-strand DNA triple-helix formation; Biochemistry; Vol. 29; No. 42; 9761-9765; 10.1021/bi00494a001
• Graham, Kenneth S. and Dervan, Peter B. (1990) Structural motif of the DNA binding domain of γδ-resolvase characterized by affinity cleaving; Journal of Biological Chemistry; Vol. 265; No. 27; 16534-16540
• Maher, L. James, III and Dervan, Peter B., et el. (1990) Kinetic analysis of oligodeoxyribonucleotide-directed triple-helix formation on DNA; Biochemistry; Vol. 29; No. 37; 8820-8826; 10.1021/bi00489a045
• Sluka, James P. and Griffin, John H., et el. (1990) Reagents and methods for the solid-phase synthesis of protein-EDTA for use in affinity cleaving; Journal of the American Chemical Society; Vol. 112; No. 17; 6369-6374; 10.1021/ja00173a027
• Mack, David P. and Sluka, James P., et el. (1990) Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site; Biochemistry; Vol. 29; No. 28; 6561-6567; 10.1021/bi00480a003
• Sluka, James P. and Horvath, Suzanna J., et el. (1990) Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase; Biochemistry; Vol. 29; No. 28; 6551-6561; 10.1021/bi00480a002
• Strobel, Scott A. and Dervan, Peter B. (1990) Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation; Science; Vol. 249; No. 4964; 73-75; 10.1126/science.2195655
• Mack, David P. and Dervan, Peter B. (1990) Nickel-mediated sequence-specific oxidative cleavage of DNA by a designed metalloprotein; Journal of the American Chemical Society; Vol. 112; No. 11; 4604-4606; 10.1021/ja00167a102
• Oakley, Martha G. and Dervan, Peter B. (1990) Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving; Science; Vol. 248; No. 4957; 847-850; 10.1126/science.2111578
• Horne, David A. and Dervan, Peter B. (1990) Recognition of mixed-sequence duplex DNA by alternate-strand triple-helix formation; Journal of the American Chemical Society; Vol. 112; No. 6; 2435-2437; 10.1021/ja00162a063
• Luebke, Kevin J. and Dervan, Peter B. (1989) Nonenzymatic ligation of oligodeoxyribonucleotides on a duplex DNA template by triple-helix formation; Journal of the American Chemical Society; Vol. 111; No. 23; 8733-8735; 10.1021/ja00205a033
• Griffin, Linda C. and Dervan, Peter B. (1989) Recognition of Thymine Adenine Base Pairs by Guanine in a Pyrimidine Triple Helix Motif; Science; Vol. 245; No. 4921; 967-971; 10.1126/science.2549639
• Strobel, Scott A. and Dervan, Peter B. (1989) Cooperative site specific binding of oligonucleotides to duplex DNA; Journal of the American Chemical Society; Vol. 111; No. 18; 7286-7287; 10.1021/ja00200a073
• Maher, Louis J., III and Wold, Barbara, et el. (1989) Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation; Science; Vol. 245; No. 4919; 725-730; 10.1126/science.2549631
• Wang, Andrew H.-J. and Cottens, Sylvain, et el. (1989) Interactions between a symmetrical minor groove binding compound and DNA oligonucleotides: ^1H and ^(19)F NMR studies; Journal of Biomolecular Structure and Dynamics; Vol. 7; No. 1; 101-117; 10.1080/07391102.1989.10507754
• Martello, Pamela A. and Bruzik, James P., et el. (1989) Specific activation of open complex formation at an Escherichia coli promoter by oligo(N-methylpyrrolecarboxamide)s: effects of peptide length and identification of DNA target sites; Biochemistry; Vol. 28; No. 10; 4455-61; 10.1021/bi00436a050
• Povsic, Thomas J. and Dervan, Peter B. (1989) Triple helix formation by oligonucleotides on DNA extended to the physiological pH range; Journal of the American Chemical Society; Vol. 111; No. 8; 3059-3061; 10.1021/ja00190a047
• Baker, Brenda F. and Dervan, Peter B. (1989) Sequence-specific cleavage of DNA by N-bromoacetyldistamycin. Product and kinetic analyses; Journal of the American Chemical Society; Vol. 111; No. 7; 2700-2712; 10.1021/ja00189a054
• Strobel, Scott A. and Moser, Heinz E., et el. (1988) Double strand cleavage of genomic DNA at a single site by triple helix formation; Journal of the American Chemical Society; Vol. 110; No. 23; 7927-7929; 10.1021/ja00231a082
• Mack, David P. and Iverson, Brent L., et el. (1988) Design and chemical synthesis of a sequence-specific DNA-cleaving protein; Journal of the American Chemical Society; Vol. 110; No. 22; 7572-7574; 10.1021/ja00230a067
• Iverson, Brent L. and Dervan, Peter B. (1988) Nonenzymatic sequence-specific methyl transfer to single-stranded DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 85; No. 13; 4615-4619; PMCID PMC280485
• Dervan, Peter B. (1988) John D. Roberts; Aldrichimica Acta; Vol. 21; No. 3; 71-77
• Youngquist, R. Scott and Dervan, Peter B. (1987) A synthetic peptide binds 16 base pairs of A,T double helical DNA; Journal of the American Chemical Society; Vol. 109; No. 24; 7564-7566; 10.1021/ja00258a070
• Sluka, James P. and Horvath, Suzanna J., et el. (1987) Synthesis of a sequence-specific DNA-cleaving peptide; Science; Vol. 238; No. 4830; 1129-1132; 10.1126/science.3120311
• Moser, Heinz E. and Dervan, Peter B. (1987) Sequence-specific cleavage of double helical DNA by triple helix formation; Science; Vol. 238; No. 4827; 645-650; 10.1126/science.3118463
• Griffin, John H. and Dervan, Peter B. (1987) Metalloregulation in the sequence specific binding of synthetic molecules to DNA; Journal of the American Chemical Society; Vol. 109; No. 22; 6840-6842; 10.1021/ja00256a043
• Iverson, Brent L. and Dervan, Peter B. (1987) Adenine specific DNA chemical sequencing reaction; Nucleic Acids Research; Vol. 15; No. 19; 7823-7830; PMCID PMC306310; 10.1093/nar/15.19.7823
• Joran, A. D. and Leland, B. A., et el. (1987) Effect of exothermicity on electron transfer rates in photosynthetic molecular models; Nature; Vol. 327; No. 6122; 508-511; 10.1038/327508a0
• Wade, Warren S. and Dervan, Peter B. (1987) Alteration of the sequence specificity of distamycin on DNA by replacement of an N-methylpyrrolecarboxamide with pyridine-2-carboxamide; Journal of the American Chemical Society; Vol. 109; No. 5; 1574-1575; 10.1021/ja00239a050
• Iverson, Brent L. and Dervan, Peter B. (1987) Nonenzymatic sequence-specific cleavage of single-stranded DNA to nucleotide resolution. DNA methyl thioether probes; Journal of the American Chemical Society; Vol. 109; No. 4; 1241-1243; 10.1021/ja00238a041
• Mendel, David and Dervan, Peter B. (1987) Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 84; No. 4; 910-914; PMCID PMC304329
• Griffin, John H. and Dervan, Peter B. (1986) Sequence-specific recognition of right-handed double-helical DNA by (2S,3S)- and (2R,3R)-dihydroxybis(netropsin)succinamide; Journal of the American Chemical Society; Vol. 108; No. 16; 5008-5009; 10.1021/ja00276a052
• Dervan, Peter B. and Baker, Brenda F. (1986) Design of sequence-specific DNA cleaving molecules: Comparison of distamycin-EDTA • Fe(II) and N-bromoacetyldistamycin; Annals of the New York Academy of Sciences; Vol. 471; 51-59; 10.1111/j.1749-6632.1986.tb48025.x
• Dervan, Peter B. (1986) Design of Sequence-Specific DNA-Binding Molecules; Science; Vol. 232; No. 4749; 464-471; 10.1126/science.2421408
• Baker, Brenda F. and Dervan, Peter B. (1985) Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin; Journal of the American Chemical Society; Vol. 107; No. 26; 8266-8268; 10.1021/ja00312a079
• Leland, B. A. and Joran, A. D., et el. (1985) Picosecond Fluorescence Studies on Intramolecular Photochemical Electron Transfer in Porphyrins Linked to Quinones at Two Different Fixed Distances; Journal of Physical Chemistry; Vol. 89; No. 26; 5571-5573; 10.1021/j100272a002
• Berger, Carole L. and Cantor, Charles, et el. (1985) Comparison of synthetic psoralen derivatives and 8-MOP in the inhibition of lymphocyte proliferation; Annals of the New York Academy of Sciences; Vol. 453; 80-90; 10.1111/j.1749-6632.1985.tb11800.x
• Youngquist, R. Scott and Dervan, Peter B. (1985) Sequence-specific recognition of B DNA by bis(EDTA-distamycin)fumaramide; Journal of the American Chemical Society; Vol. 107; No. 19; 5528-5529; 10.1021/ja00305a036
• Harshman, Keith D. and Dervan, Peter B. (1985) Molecular recognition of B-DNA by Hoechst 33258; Nucleic Acids Research; Vol. 13; No. 13; 4825-4835; PMCID PMC321829; 10.1093/nar/13.13.4825
• Youngquist, R. Scott and Dervan, Peter B. (1985) Sequence-specific recognition of B-DNA by oligo(N-methylpyrrolecarboxamide)s; Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 9; 2565-2569; PMCID PMC397604
• Dreyer, Geoffrey B. and Dervan, Peter B. (1985) Sequence-specific cleavage of single-stranded DNA: Oligodeoxynucleotide-EDTA·Fe(II); Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 4; 968-972; PMCID PMC397174
• Joran, Alvin D. and Leland, Burt A., et el. (1984) Models for photochemical electron transfer at fixed distances. Porphyrin-bicyclo[2.2.2]octane-quinone and porphyrin-bisbicyclo[2.2.2]octane-quinone; Journal of the American Chemical Society; Vol. 106; No. 20; 6090-6092; 10.1021/ja00332a062
• Van Dyke, Michael M. and Dervan, Peter B. (1984) Echinomycin Binding Sites on DNA; Science; Vol. 225; No. 4667; 1122-1127; 10.1126/science.6089341
• Hertzberg, Robert P. and Dervan, Peter B. (1984) Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses; Biochemistry; Vol. 23; No. 17; 3934-3945; 10.1021/bi00312a022
• Sylwester, Alan P. and Dervan, Peter B. (1984) Low-temperature matrix isolation of the 1,1-diazene H_2NN. Electronic and infrared characterization; Journal of the American Chemical Society; Vol. 106; No. 16; 4648-4650; 10.1021/ja00328a076
• Schultz, Peter G. and Dervan, Peter B. (1984) Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving; Journal of Biomolecular Structure and Dynamics; Vol. 1; No. 5; 1133-1147; 10.1080/07391102.1984.10507508
• Taylor, John S. and Schultz, Peter G., et el. (1984) DNA affinity cleaving : Sequence specific cleavage of DNA by Distamycin-EDTA • Fe(II) and EDTA-distamycin • Fe(II); Tetrahedron; Vol. 40; No. 3; 457-465; 10.1016/0040-4020(84)85050-4
• Schultz, P. G. and Dervan, P. B. (1983) Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin•Fe^(II)) and EDTA-bis(distamycin)•Fe^(II); Journal of the American Chemical Society; Vol. 105; No. 26; 7748-7750; 10.1021/ja00364a049
• Schultz, Peter G. and Dervan, Peter B. (1983) Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA·Fe(II); Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 22; 6834-6837; PMCID PMC390080
• Van Dyke, Michael W. and Dervan, Peter B. (1983) Methidiumpropyl-EDTA•Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA; Nucleic Acids Research; Vol. 11; No. 16; 5555-5567; PMCID PMC326297; 10.1093/nar/11.16.5555
• Cartwright, Iain L. and Hertzberg, Robert P., et el. (1983) Cleavage of chromatin with methidiumpropyl-EDTA·iron(II); Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 11; 3213-3217; PMCID PMC394010
• Van Dyke, Michael W. and Dervan, Peter B. (1983) Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous DNA. Footprinting with methidiumpropyl-EDTA•iron(II); Biochemistry; Vol. 22; No. 10; 2373-2377; 10.1021/bi00279a011
• Duan, Daniel C. and Dervan, Peter B. (1983) Evidence for a stereospecific 1,2-elimination reaction in a 1,1-diazene. Synthesis and decomposition of [N-phenyl(threo- and erythro)-2-deuterio-1-methylpropyl)amino]nitrene; Journal of Organic Chemistry; Vol. 48; No. 7; 970-976; 10.1021/jo00155a008
• Van Dyke, M. W. and Dervan, P. B. (1983) Footprinting with MPE•Fe(II). Complementary-strand analyses of distamycin- and actinomycin-binding sites on heterogeneous DNA; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 47; 347-353; 10.1101/SQB.1983.047.01.040
• Van Dyke, M. W. and Dervan, P. B. (1983) Footprinting with MPE·Fe(II). Complementary-strand Analyses of Distamycin- and Actinomycin-binding Sites on Heterogeneous DNA; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 47; No. Pt 1; 347-353; 10.1101/SQB.1983.047.01.040
• Schultz, Peter G. and Taylor, John S., et el. (1982) Design synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron(II); Journal of the American Chemical Society; Vol. 104; No. 24; 6861-6863; 10.1021/ja00388a101
• Schultz, Peter G. and Dervan, Peter B. (1982) Photochemistry of 1,1-diazenes. Direct and sensitized photolyses of N-(2,2,5,5-tetramethylpyrrolidyl)nitrene, dl-N-(2,5-diethyl-2,5-dimethylpyrrolidyl)nitrene, and N-(2,2,6,6-tetramethylpiperidyl)nitrene; Journal of the American Chemical Society; Vol. 104; No. 24; 6660-6668; 10.1021/ja00388a031
• McIntyre, Daniel K. and Dervan, Peter B. (1982) 1,1-Di-tert-butyldiazene; Journal of the American Chemical Society; Vol. 104; No. 23; 6466-6468; 10.1021/ja00387a061
• Van Dyke, Michael W. and Hertzberg, Robert P., et el. (1982) Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA·Fe(II); Proceedings of the National Academy of Sciences of the United States of America; Vol. 79; No. 18; 5470-5474; PMCID PMC346925
• Mitchell, Mark A. and Dervan, Peter B. (1982) Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid; Journal of the American Chemical Society; Vol. 104; No. 15; 4265-4266; 10.1021/ja00379a045
• Hinsberg, William D., III and Schultz, Peter G., et el. (1982) Direct studies of 1,1-diazenes. Syntheses, infrared and electronic spectra, and kinetics of the thermal decomposition of N-(2,2,6,6-tetramethylpiperidyl)nitrene and N-(2,2,5,5-tetramethylpyrrolidyl)nitrene; Journal of the American Chemical Society; Vol. 104; No. 3; 766-773; 10.1021/ja00367a020
• Ikeda, Richard A. and Dervan, Peter B. (1982) Sequence-selective inhibition of restriction endonucleases by the polyintercalator bis(methidium)spermine; Journal of the American Chemical Society; Vol. 104; No. 1; 296-297; 10.1021/ja00365a058
• Hertzberg, Robert P. and Dervan, Peter B. (1982) Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II); Journal of the American Chemical Society; Vol. 104; No. 1; 313-315; 10.1021/ja00365a069
• Dervan, Peter B. and Squillacote, Michael E., et el. (1981) ^(15)N NMR Spectrum of a 1,1-Diazene. N-(2,2,6,6-Tetramethylpiperidyl)nitrene; Journal of the American Chemical Society; Vol. 103; No. 5; 1120-1122; 10.1021/ja00395a021
• Schultz, Peter G. and Dervan, Peter B. (1981) Photochemistry of a 1,1-diazene, N-(2,2,5,5-tetramethylpyrrolidinyl)nitrene; Journal of the American Chemical Society; Vol. 103; No. 6; 1563-1564; 10.1021/ja00396a048
• Dervan, Peter B. and Santilli, Donald S. (1980) Synthesis and thermal decomposition of cis-3,4,5,6-tetrahydropyridazine-3,4-d2. Relative rates of rotation, cleavage, and closure for tetramethylene; Journal of the American Chemical Society; Vol. 102; No. 11; 3863-3870; 10.1021/ja00531a031
• Schultz, Peter G. and Dervan, Peter B. (1980) Synthesis and direct spectroscopic observation of N-(2,2,5,5-tetramethylpyrrolidinyl)nitrene. Comparison of five- and six-membered cyclic 1,1-dialkyldiazenes; Journal of the American Chemical Society; Vol. 102; No. 2; 878-880; 10.1021/ja00522a090
• Hinsberg, William D., III and Dervan, Peter B. (1979) Kinetics of the thermal decomposition of a 1,1-dialkyldiazene, N-(2,2,6,6-tetramethylpiperidyl)nitrene; Journal of the American Chemical Society; Vol. 101; No. 20; 6142-6144; 10.1021/ja00514a058
• Becker, Michael McClellan and Dervan, Peter B. (1979) Molecular recognition of nucleic acid by small molecules. Binding affinity and structural specificity of bis(methidium)spermine; Journal of the American Chemical Society; Vol. 101; No. 13; 3664-3666; 10.1021/ja00507a046
• Santilli, Donald S. and Dervan, Peter B. (1979) Thermal decomposition of cis-tetrahydropyridazine-3,4-d_2. Relative rates of rotation, cleavage, and closure for tetramethylene; Journal of the American Chemical Society; Vol. 101; No. 13; 3663-3664; 10.1021/ja00507a045
• Dervan, Peter B. and Jones, Carol R. (1979) Syntheses and Decomposition of meso- and dl-2,3-Dimethylsuccinyl and cis- and trans-1,2-Hexahydrophthaloyl Peroxides; Journal of Organic Chemistry; Vol. 44; No. 13; 2116-2123; 10.1021/jo01327a016
• Dervan, Peter B. and Uyehara, Tadao (1979) Stereochemical tests of cyclic 1,1-dialkyldiazene fragmentation reactions. Thermal decomposition of N-(cis-(and trans-)2,3-(and 2,5-)dimethylpyrrolidine)nitrenes; Journal of the American Chemical Society; Vol. 101; No. 8; 2076-2082; 10.1021/ja00502a023
• Dervan, Peter B. and Uyehara, Tadao, et el. (1979) Experimental determination of the relative rates of rotation, cleavage, closure, and 1,5-hydrogen shift for 3-methyl-1,4-pentanediyl. Evidence for 1,4 biradicals as common intermediates from different precursors, 3,4-(and 3,6-)dimethyl-3,4,5,6-tetrahydropyridazines and 1,2-dimethylcyclobutanes; Journal of the American Chemical Society; Vol. 101; No. 8; 2069-2075; 10.1021/ja00502a022
• Dervan, Peter B. and Becker, Michael M. (1978) Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule; Journal of the American Chemical Society; Vol. 100; No. 6; 1968-1970; 10.1021/ja00474a075
• Hinsberg, William D., III and Dervan, Peter B. (1978) Synthesis and direct spectroscopic observation of a 1,1-dialkyldiazene. Infrared and electronic spectrum of N-(2,2,6,6-tetramethylpiperidyl)nitrene; Journal of the American Chemical Society; Vol. 100; No. 5; 1608-1610; 10.1021/ja00473a051
• Jones, Carol R. and Dervan, Peter B. (1977) Six-membered cyclic diacyl peroxide fragmentations. Thermal decomposition of meso- and dl-2,3-dimethylsuccinoyl peroxides; Journal of the American Chemical Society; Vol. 99; No. 20; 6772-6774; 10.1021/ja00462a058
• Shippey, Michael A. and Dervan, Peter B. (1977) Trimethylsilyl anions. Direct synthesis of trimethylsilylbenzenes; Journal of Organic Chemistry; Vol. 42; No. 15; 2654-2655; 10.1021/jo00435a037
• Berson, Jerome A. and Dervan, Peter B., et el. (1976) Formation and thermal rearrangements of some dimers of butadiene and piperylene. Tests of the validity of thermochemical-kinetic arguments for identification of common biradical intermediates; Journal of the American Chemical Society; Vol. 98; No. 19; 5937-5968; 10.1021/ja00435a031
• Dervan, Peter B. and Uyehara, Tadao (1976) A stereochemical test of similarly substituted tetramethylenediazene and cyclic azo decompositions in the gas phase at the same temperature; Journal of the American Chemical Society; Vol. 98; No. 7; 2003-2005; 10.1021/ja00423a078
• Dervan, Peter B. and Uyehara, Tadao (1976) Thermal decomposition of cis- and trans-3,4- and -3,6-dimethyl-3,4,5,6-tetrahydropyridazines. Evidence against the hot diradical postulate for azo decompositions; Journal of the American Chemical Society; Vol. 98; No. 5; 1262-1264; 10.1021/ja00421a037
• Dervan, Peter B. and Shippey, Michael A. (1976) Trimethylsilylpotassium. Deoxygenation of epoxides with inversion of stereochemistry; Journal of the American Chemical Society; Vol. 98; No. 5; 1265-1267; 10.1021/ja00421a039
• Dervan, Peter B. and Uyehara, Tadao (1976) 7-Azabicyclo[2.2.1]heptane N-Imide as an Intermediate in the Thermal Decomposition of N-Amino-7-Azabicyclo[2.2.1]heptane and the Corresponding Benzenesulphonamide; Journal of the Chemical Society. Chemical Communications; Vol. 1976; No. 12; 469-470; 10.1039/C39760000469
• Berson, Jerome A. and Dervan, Peter B. (1973) Rearrangement of trans-1,2-divinylcyclobutane and the energy surface of the dimers of butadiene; Journal of the American Chemical Society; Vol. 95; No. 1; 267-269; 10.1021/ja00782a061
• Berson, Jerome A. and Dervan, Peter B. (1973) Mechanistic analysis of the four pathways in the 1,3-sigmatropic rearrangements of trans-1,2-trans, trans- and trans-1,2-cis,trans-dipropenylcyclobutane; Journal of the American Chemical Society; Vol. 95; No. 1; 269-270; 10.1021/ja00782a062
• Berson, Jerome A. and Dervan, Peter B. (1972) Stereodistal Cope rearrangement of trans-1,2-dialkenylcyclobutanes; Journal of the American Chemical Society; Vol. 94; No. 25; 8949-8950; 10.1021/ja00780a074
• Berson, Jerome A. and Dervan, Peter B. (1972) Incremental substituent effects leading to steric blockade of the boat-like six-center Cope rearrangement of cis-1,2-dialkenylcyclobutanes; Journal of the American Chemical Society; Vol. 94; No. 21; 7597-7598; 10.1021/ja00776a064
• Berson, Jerome A. and Dervan, Peter B., et el. (1972) Stereospecific double rearrangement of trans-3,4-dimethyl-cis,trans-cycloocta-1,5-diene to cis-3,4-dimethyl-cis,cis-cycloocta-1,5-diene; Journal of the American Chemical Society; Vol. 94; No. 21; 7598-7599; 10.1021/ja00776a065
• Bennett, O. Francis and Bouchard, M. J., et el. (1972) Hydroxide displacement of the sulfone linkage in thioxanthen-9-one 10,10-dioxides to benzophenone-2'-hydroxy-2-sulfinic acids. Intramolecular cyclization to xanthones; Journal of Organic Chemistry; Vol. 37; No. 9; 1356-1359; 10.1021/jo00974a015