Deshaies, Raymond

Combined from CaltechAUTHORS

• Sherman, David J. and Liu, Lei, et el. (2024) The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamics; Proceedings of the National Academy of Sciences; Vol. 121; No. 18; e2318619121; PMCID PMC11067037; 10.1073/pnas.2318619121
• Mamrosh, Jennifer L. and Sherman, David J., et el. (2023) Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation; Science Advances; Vol. 9; No. 25; eade7890; PMCID PMC10289651; 10.1126/sciadv.ade7890
• Zhang, Yaru and Jost, Marco, et el. (2022) Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication; Proceedings of the National Academy of Sciences of the United States of America; Vol. 119; No. 36; Art. No. e2205608119; PMCID PMC9456757; 10.1073/pnas.2205608119
• Mamrosh, Jennifer L. and Sherman, David J., et el. (2021) A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways; 10.1101/2021.10.07.463289
• Porras-Yakushi, Tanya R. and Reitsma, Justin M., et el. (2021) In depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted; Journal of Proteomics; Vol. 241; Art. No. 104197; 10.1016/j.jprot.2021.104197
• Zhang, Gang and Li, Shan, et el. (2021) A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells; European Journal of Medicinal Chemistry; Vol. 213; Art. No. 113148; PMCID PMC7954469; 10.1016/j.ejmech.2020.113148
• Arango-Gonzalez, Blanca and Sen, Merve, et el. (2020) Inhibition of VCP preserves retinal structure and function in autosomal dominant retinal degeneration; 10.1101/2020.11.17.384669
• Yang, Seung-Joo and Jeon, Seung-Je, et el. (2020) Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity; Biochimica et Biophysica Acta; Vol. 1867; No. 8; Art. No. 118729; 10.1016/j.bbamcr.2020.118729
• Reichermeier, Kurt M. and Straube, Ronny, et el. (2020) PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network; Molecular Cell; Vol. 77; No. 5; 1092-1106; 10.1016/j.molcel.2019.12.013
• Blythe, Emily E. and Gates, Stephanie N., et el. (2019) Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing; Structure; Vol. 27; No. 12; 1820-1829; PMCID PMC6929323; 10.1016/j.str.2019.09.011
• Yu, Helen H. and Reitsma, Justin M., et el. (2019) Single subunit degradation of WIZ, a lenalidomide- and pomalidomide dependent substrate of E3 ubiquitin ligase CRL4^(CRBN); 10.1101/595389
• Li, Jing and Zhang, Yaru, et el. (2018) Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11; Cell Chemical Biology; Vol. 25; No. 11; 1350-1358; PMCID PMC6309308; 10.1016/j.chembiol.2018.07.012
• Verma, Rati and Reichermeier, Kurt M., et el. (2018) Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes; Nature; Vol. 557; No. 7705; 446-451; PMCID PMC6226276; 10.1038/s41586-018-0022-5
• Lobanova, Ekaterina S. and Finkelstein, Stella, et el. (2018) Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration; Nature Communications; Vol. 9; Art. No. 1738; PMCID PMC5928105; 10.1038/s41467-018-04117-8
• Liu, Xing and Reitsma, Justin M., et el. (2018) Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression; Molecular Cell; Vol. 69; No. 5; 773-786; PMCID PMC5836512; 10.1016/j.molcel.2018.01.038
• Blythe, E. E. and Martin, A., et el. (2017) Characterization of p97 mutations causing multisystem proteinopathy support a gain-of-function model for pathology; Molecular Biology of the Cell; Vol. 28; No. 26; Art. No. M125; 10.1091/mbc.E17-10-0618
• Skrott, Zdenek and Li, Jing, et el. (2017) Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4; Nature; Vol. 552; No. 7684; 194-199; PMCID PMC5730499; 10.1038/nature25016
• Nakasone, Mark A. and Lewis, Timothy A., et el. (2017) Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway; Structure; Vol. 25; No. 12; 1839-1855; 10.1016/j.str.2017.10.007
• Reitsma, Justin M. and Liu, Xing, et el. (2017) Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases; Cell; Vol. 171; No. 6; 1326-1339; PMCID PMC5711595; 10.1016/j.cell.2017.10.016
• Lauinger, Linda and Li, Jing, et el. (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases; Nature Chemical Biology; Vol. 13; No. 7; 709-714; 10.1038/nchembio.2370
• Blythe, Emily E. and Olson, Kristine C., et el. (2017) Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy; Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 22; E4380-E4388; PMCID PMC5465906; 10.1073/pnas.1706205114
• Li, Jing and Yakushi, Tanya, et el. (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11; Nature Chemical Biology; Vol. 13; No. 5; 486-493; PMCID PMC5570473; 10.1038/nchembio.2326
• Nguyen, Van Thang and Li, Jing, et el. (2017) p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates; Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 14; 3565-3571; PMCID PMC5389304; 10.1073/pnas.1700949114
• Reiterer, Veronika and Figueras-Puig, Cristina, et el. (2017) The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCF^(FBXW7) function; EMBO Journal; Vol. 36; No. 3; 260-273; PMCID PMC5286380; 10.15252/embj.201694795
• Vangala, Janakiram R. and Sotzny, Franziska, et el. (2016) Nrf1 can be processed and activated in a proteasome-independent manner; Current Biology; Vol. 26; No. 18; R834-R835; PMCID PMC6156719; 10.1016/j.cub.2016.08.008
• Sung, Min-Kyung and Reitsma, Justin M., et el. (2016) Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system; Molecular Biology of the Cell; Vol. 27; No. 17; 2642-2652; PMCID PMC5007085; 10.1091/mbc.E16-05-0290
• Xue, Liang and Blythe, Emily E., et el. (2016) Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor; Molecular and Cellular Proteomics; Vol. 15; No. 9; 2970-2986; PMCID PMC5013311; 10.1074/mcp.M116.061036
• Kleiger, Gary and Deshaies, Raymond (2016) Tag Team Ubiquitin Ligases; Cell; Vol. 166; No. 5; 1080-1081; 10.1016/j.cell.2016.08.014
• Sung, Min-Kyung and Porras-Yakushi, Tanya R., et el. (2016) A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins; eLife; Vol. 5; Art. No. e19105; PMCID PMC5026473; 10.7554/eLife.19105
• Mosadeghi, Ruzbeh and Reichermeier, Kurt M., et el. (2016) Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle; eLife; Vol. 5; Art. No. e12102; PMCID PMC4878873; 10.7554/eLife.12102
• Nguyen, Thang Van and Lee, J. Eugene, et el. (2016) Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon; Molecular Cell; Vol. 61; No. 6; 809-820; PMCID PMC4889030; 10.1016/j.molcel.2016.02.032
• Banerjee, Sooiay and Bartesaghi, Alberto, et el. (2016) 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition; Science; Vol. 351; No. 6275; 871-875; 10.1126/science.aad7974
• Alverez, Celeste and Bulfer, Stacie L., et el. (2016) Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway; ACS Medicinal Chemistry Letters; Vol. 7; No. 2; 182-187; 10.1021/acsmedchemlett.5b00396
• Deshaies, Raymond J. (2015) Protein degradation: Prime time for PROTACs; Nature Chemical Biology; Vol. 11; No. 9; 634-635; 10.1038/nchembio.1887
• Deshaies, Raymond and Li, Jing (2015) Exploiting protein homeostasis for cancer therapy
• Pulvino, Mary and Chen, Luojing, et el. (2015) Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline; Oncotarget; Vol. 6; No. 17; 14796-14813; PMCID PMC4558116; 10.18632/oncotarget.4193
• Fang, Nancy N. and Chan, Gerard T., et el. (2014) Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress; Nature Cell Biology; Vol. 16; No. 12; 1227-1237; PMCID PMC5224936; 10.1038/ncb3054
• Deshaies, Raymond J. (2014) Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy; BMC Biology; Vol. 12; Art. No. 94; PMCID PMC4226866; 10.1186/s12915-014-0094-0
• Deshaies, Raymond J. (2014) Corralling a protein-degradation regulator; Nature; Vol. 512; No. 7513; 145-146; 10.1038/nature13644
• Chou, Tsui-Fen and Bulfer, Stacie L., et el. (2014) Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains; Journal of Molecular Biology; Vol. 426; No. 15; 2886-2899; PMCID PMC4102644; 10.1016/j.jmb.2014.05.022
• Deshaies, Raymond J. (2014) Structural biology: Corralling a protein-degradation regulator; Nature; 10.1038/nature13644
• Chan, Nickie C. and den Besten, Willem, et el. (2014) Degradation of the Deubiquitinating Enzyme USP33 is Mediated by p97 and the Ubiquitin Ligase HERC2; Journal of Biological Chemistry; Vol. 289; No. 28; 19789-19798; PMCID PMC4094088; 10.1074/jbc.M114.569392
• Deshaies, Raymond and Chou, Tsui-Fen, et el. (2014) Exploiting protein homeostasis for cancer therapy; FASEB Journal; Vol. 28; No. 1; 472.2
• Honarpour, Narimon and Rose, Christopher M., et el. (2014) F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage; Molecular and Cellular Proteomics; Vol. 13; No. 3; 780-791; PMCID PMC3945908; 10.1074/mcp.M113.031765
• Radhakrishnan, Senthil K. and den Besten, Willem, et el. (2014) p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition; eLife; Vol. 3; Art. No. e01856; PMCID PMC3896944; 10.7554/elife.01856
• Kolawa, Natalie and Sweredoski, Michael J., et el. (2013) Perturbations to the Ubiquitin Conjugate Proteome in Yeast Δubx Mutants Identify Ubx2 as a Regulator of Membrane Lipid Composition; Molecular and Cellular Proteomics; Vol. 12; No. 10; 2791-2803; PMCID PMC3790291; 10.1074/mcp.M113.030163
• Kurimchak, Alison and Haines, Dale S., et el. (2013) Activation of p107 by Fibroblast Growth Factor, Which Is Essential for Chondrocyte Cell Cycle Exit, Is Mediated by the Protein Phosphatase 2A/B55α Holoenzyme; Molecular and Cellular Biology; Vol. 33; No. 16; 3330-3342; PMCID PMC3753905; 10.1128/MCB.00082-13
• Shi, Yihui and Liu, Xiaohe, et el. (2013) Development of functional assays for p97/VCP inhibition; Cancer Research; Vol. 73; No. 8; Art. No. 2146; 10.1158/1538-7445.AM2013-2146
• Pierce, Nathan W. and Lee, J. Eugene, et el. (2013) Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins; Cell; Vol. 153; No. 1; 206-215; PMCID PMC3656483; 10.1016/j.cell.2013.02.024
• Chou, Tsui-Fen and Li, Kelin, et el. (2013) Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase; ChemMedChem; Vol. 8; No. 2; 297-312; PMCID PMC3662613; 10.1002/cmdc.201200520
• Verma, Rati and Oania, Robert S., et el. (2013) Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome; eLife; Vol. 2013; No. 2; Art. No. e00308; PMCID PMC3552423; 10.7554/eLife.00308
• Emberley, Ethan D. and Mosadeghi, Ruzbeh, et el. (2012) Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism; Journal of Biological Chemistry; Vol. 287; No. 35; 29679-29689; PMCID PMC3436198; 10.1074/jbc.M112.352484
• Oh, Younghoon and Chang, Kuang-Jung, et el. (2012) Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast; Molecular Biology of the Cell; Vol. 23; No. 13; 2445-2456; PMCID PMC3386209; 10.1091/mbc.E12-01-0033
• Haines, Dale S. and Lee, J. Eugene, et el. (2012) Protein Interaction Profiling of the p97 Adaptor UBXD1 Points to a Role for the Complex in Modulating ERGIC-53 Trafficking; Molecular and Cellular Proteomics; Vol. 11; No. 6; Art. No. M111.016444; PMCID PMC3433925; 10.1074/mcp.M111.016444
• den Besten, Willem and Verma, Rati, et el. (2012) NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway; Nature Structural & Molecular Biology; Vol. 19; No. 5; 511-516; PMCID PMC3348432; 10.1038/nsmb.2269
• Sohn, Chang Ho and Agnew, Heather D., et el. (2012) Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions; Analytical Chemistry; Vol. 84; No. 6; 2662-2669; PMCID PMC3310289; 10.1021/ac202637n
• Sohn, Chang Ho and Lee, J. Eugene, et el. (2012) Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification; Journal of the American Chemical Society; Vol. 134; No. 5; 2672-2680; PMCID PMC3668889; 10.1021/ja2099003
• Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Development of p97 AAA ATPase inhibitors; Autophagy; Vol. 7; No. 9; 1091-1092; PMCID PMC3210319; 10.4161/auto.7.9.16489
• Rabut, Gwenaël and Le Dez, Gaëlle, et el. (2011) The TFIIH Subunit Tfb3 Regulates Cullin Neddylation; Molecular Cell; Vol. 43; No. 3; 488-495; PMCID PMC3186349; 10.1016/j.molcel.2011.05.032
• Gomez, Tara A. and Kolawa, Natalie, et el. (2011) Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1; BMC Biology; Vol. 9; Art. No. 33; PMCID PMC3126750; 10.1186/1741-7007-9-33
• Chou, Tsui-Fen and Deshaies, Raymond J. (2011) Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System; Journal of Biological Chemistry; Vol. 286; No. 19; 16546-16554; PMCID PMC3089497; 10.1074/jbc.M110.215319
• Lee, J. Eugene and Sweredoski, Michael J., et el. (2011) The steady-state repertoire of human SCF Ubiquitin ligase complexes does not require ongoing Nedd8 conjugation; Molecular and Cellular Proteomics; Vol. 10; No. 5; Art. No. M110.006460; PMCID PMC3098594; 10.1074/mcp.M110.006460
• Saha, Anjanabha and Lewis, Steven, et el. (2011) Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate; Molecular Cell; Vol. 42; No. 1; 75-83; PMCID PMC3091889; 10.1016/j.molcel.2011.03.016
• Chou, Tsui-Fen and Brown, Steve J., et el. (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proceedings of the National Academy of Sciences of the United States of America; Vol. 108; No. 12; 4834-4839; PMCID PMC3064330; 10.1073/pnas.1015312108
• Verma, Rati and Oania, Robert, et el. (2011) Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II; Molecular Cell; Vol. 41; No. 1; 82-92; PMCID PMC3063307; 10.1016/j.molcel.2010.12.017
• Chou, T. and Deshaies, R. (2010) Development of p97 inhibitors as potential anti-cancer therapeutics
• Tyrrell, An and Flick, Karin, et el. (2010) Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins; Proceedings of the National Academy of Sciences of the United States of America; Vol. 107; No. 46; 19796-19801; PMCID PMC2993400; 10.1073/pnas.1010648107
• Collins, Galen A. and Gomez, Tara Adele, et el. (2010) Combined chemical and genetic approach to inhibit proteolysis by the proteasome; Yeast; Vol. 27; No. 11; 965-974; PMCID PMC3566228; 10.1002/yea.1805
• Aghajan, Mariam and Jonai, Nao, et el. (2010) Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase; Nature Biotechnology; Vol. 28; No. 7; 738-742; PMCID PMC2902569; 10.1038/nbt.1645
• Radhakrishnan, Senthil K. and Lee, Candy S., et el. (2010) Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells; Molecular Cell; Vol. 38; No. 1; 17-28; PMCID PMC2874685; 10.1016/j.molcel.2010.02.029
• Kleiger, Gary and Hao, Bing, et el. (2009) The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCFC^(dc4*); Journal of Biological Chemistry; Vol. 284; No. 52; 36012-36023; PMCID PMC2794717; 10.1074/jbc.M109.058529
• Pierce, Nathan W. and Kleiger, Gary, et el. (2009) Detection of sequential polyubiquitylation on a millisecond timescale; Nature; Vol. 462; No. 7273; 615-620; PMCID PMC2791906; 10.1038/nature08595
• Kleiger, Gary and Saha, Anjanabha, et el. (2009) Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates; Cell; Vol. 139; No. 5; 957-968; PMCID PMC2804849; 10.1016/j.cell.2009.10.030
• Collins, Galen A. and Lipford, J. Russell, et el. (2009) Gal4 turnover and transcription activation; Nature; Vol. 461; No. 7265; E7-E8; PMCID PMC3072683; 10.1038/nature08406
• Deshaies, Raymond J. and Joazeiro, Claudio A. P. (2009) RING domain E3 ubiquitin ligases; Annual Review of Biochemistry; Vol. 78; 399-434; 10.1146/annurev.biochem.78.101807.093809
• Deshaies, Raymond J. (2009) Drug discovery: fresh target for cancer therapy; Nature; Vol. 458; No. 7239; 709-710; 10.1038/458709a
• Oh, Young Mi and Kwon, Young Eun, et el. (2009) Chfr is linked to tumour metastasis through the downregulation of HDAC1; Nature Cell Biology; Vol. 11; No. 3; 295-302; 10.1038/ncb1837
• Mohl, Dane A. and Huddleston, Michael J., et el. (2009) Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis; Journal of Cell Biology; Vol. 184; No. 4; 527-539; PMCID PMC2654127; 10.1083/jcb.200812022
• Machida, Keigo and Tsukamoto, Hidekazu, et el. (2009) Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 5; 1548-1553; PMCID PMC2635765; 10.1073/pnas.0807390106
• Rodriguez-Gonzalez, A. and Cyrus, K., et el. (2008) Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer; Oncogene; Vol. 27; No. 57; 7201-7211; PMCID PMC5573236; 10.1038/onc.2008.320
• Saha, Anjanabha and Deshaies, Raymond J. (2008) Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation; Molecular Cell; Vol. 32; No. 1; 21-31; PMCID PMC2644375; 10.1016/j.molcel.2008.08.021
• Sakamoto, K. and Rodriguez-Gonzalez, A., et el. (2008) Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer; European Journal of Cancer Supplements; Vol. 6; No. 12; 16; 10.1016/S1359-6349(08)71971-2
• Goh, Amanda M. and Walters, Kylie J., et el. (2008) Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins; BMC Biochemistry; Vol. 9; Art. No. 4; PMCID PMC2267792; 10.1186/1471-2091-9-4
• Mayor, Thibault and Graumann, Johannes, et el. (2007) Quantitative Profiling of Ubiquitylated Proteins Reveals Proteasome Substrates and the Substrate Repertoire Influenced by the Rpn10 Receptor Pathway; Molecular and Cellular Proteomics; Vol. 6; No. 11; 1885-1895; 10.1074/mcp.M700264-MCP200
• Ghaboosi, Nazli and Deshaies, Raymond J. (2007) A Conditional Yeast E1 Mutant Blocks the Ubiquitin–Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome; Molecular Biology of the Cell; Vol. 18; No. 5; 1953-1963; PMCID PMC1855034; 10.1091/mbc.E06-10-0965
• Sharon, Michal and Taverner, Thomas, et el. (2006) Structural Organization of the 19S Proteasome Lid: Insights from MS of Intact Complexes; PLoS Biology; Vol. 4; No. 8; e267; PMCID PMC1523230
• Cope, Gregory A. and Deshaies, Raymond J. (2006) Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels; BMC Biochemistry; Vol. 7; Art. No. 1; PMCID PMC1360668; 10.1186/1471-2091-7-1
• Lipford, J. Russell and Smith, Geoffrey T., et el. (2005) A putative stimulatory role for activator turnover in gene expression; Nature; Vol. 438; No. 7064; 113-116; 10.1038/nature04098
• Mah, Angie S. and Elia, Andrew E. H., et el. (2005) Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening; BMC Biochemistry; Vol. 6; Art. No. 22; PMCID PMC1277818; 10.1186/1471-2091-6-22
• Mayor, Thibault and Lipford, J. Russell, et el. (2005) Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets; Molecular and Cellular Proteomics; Vol. 4; No. 6; 741-751; 10.1074/mcp.M400220-MCP200
• Petroski, Matthew D. and Deshaies, Raymond J. (2005) Function and regulation of Cullin-RING ubiquitin ligases; Nature Reviews. Molecular Cell Biology; Vol. 6; No. 1; 9-20; 10.1038/nrm1547
• Deshaies, Raymond (2004) Varshavsky's Contributions; Science; Vol. 306; No. 5700; 1290-1292; 10.1126/science.306.5700.1290
• Verma, Rati and Peters, Noel R., et el. (2004) Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain; Science; Vol. 306; No. 5693; 117-120; 10.1126/science.1100946
• Azzam, Ramzi and Chen, Susan L., et el. (2004) Phosphorylation by Cyclin B-Cdk Underlies Release of Mitotic Exit Activator Cdc14 from the Nucleolus; Science; Vol. 305; No. 5683; 516-519; 10.1126/science.1099402
• Schneekloth, John S., Jr. and Fonseca, Fabiana N., et el. (2004) Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation; Journal of the American Chemical Society; Vol. 126; No. 12; 3748-3754; 10.1021/ja039025z
• Graumann, Johannes and Dunipace, Leslie A., et el. (2004) Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast; Molecular and Cellular Proteomics; Vol. 3; No. 3; 226-237; 10.1074/mcp.M300099-MCP200
• Wertz, Ingrid E. and O'Rourke, Karen M., et el. (2004) Human De-Etiolated-1 Regulates c-Jun by Assembling a CUL4A Ubiquitin Ligase; Science; Vol. 303; No. 5662; 1371-1374; 10.1126/science.1093549
• Ambroggio, Xavier I. and Rees, Douglas C., et el. (2004) JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome; PLoS Biology; Vol. 2; No. 1; 113-119; PMCID PMC300881; 10.1371/journal.pbio.0020002
• Sakamoto, Kathleen M. and Kim, Kyung B., et el. (2003) Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation; Molecular and Cellular Proteomics; Vol. 2; No. 12; 1350-1358; 10.1074/mcp.T300009-MCP200
• Lipford, J. Russell and Deshaies, Raymond J. (2003) Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation; Nature Cell Biology; Vol. 5; No. 10; 845-850; 10.1038/ncb1003-845
• Cope, Gregory A. and Suh, Greg S., et el. (2002) Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1; Science; Vol. 298; No. 5593; 608-611; 10.1126/science.1075901
• Verma, Rati and Aravind, L., et el. (2002) Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome; Science; Vol. 298; No. 5593; 611-615; 10.1126/science.1075898
• Shou, Wenying and Azzam, Ramzi, et el. (2002) Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex; BMC Molecular Biology; Vol. 3; No. 3; 1-14; PMCID PMC113746
• Shou, Wenying and Deshaies, Raymond J. (2002) Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae; BMC Genetics; Vol. 3; Art. No. 4; PMCID PMC102333; 10.1186/1471-2156-3-4
• Chen, Susan Loughery and Huddleston, Michael J., et el. (2002) Mass Spectrometry-based Methods for Phosphorylation Site Mapping of Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from Mitosis in Yeast; Molecular and Cellular Proteomics; Vol. 1; No. 3; 186-196; 10.1074/mcp.M100032-MCP200
• Deshaies, Raymond J. and Seol, Jae Hong, et el. (2002) Charting the protein complexome in yeast by mass spectrometry; Molecular and Cellular Proteomics; Vol. 1; No. 1; 3-10; 10.1074/mcp.R100001-MCP200
• Wu, Guangyu and Lyapina, Svetlana, et el. (2001) SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation; Molecular and Cellular Biology; Vol. 21; No. 21; 7403-7415; PMCID PMC99913; 10.1128/MCB.21.21.7403-7415.2001
• Zhou, Chunshui and Seibert, Volker, et el. (2001) The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p; BMC Biochemistry; Vol. 2; No. 7; 1-11; PMCID PMC37391; 10.1186/1471-2091-2-7
• Sakamoto, Kathleen M. and Kim, Kyung B., et el. (2001) Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 15; 8554-8559; PMCID PMC37474; 10.1073/pnas.141230798
• Mah, Angie S. and Jang, Joanne, et el. (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 13; 7325-7330; PMCID PMC34667; 10.1073/pnas.141098998
• Traverso, Edwin E. and Baskerville, Christopher, et el. (2001) Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast; Journal of Biological Chemistry; Vol. 276; No. 24; 21924-21931; 10.1074/jbc.M011689200
• Lyapina, Svetlana and Cope, Gregory, et el. (2001) Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome; Science; Vol. 292; No. 5520; 1382-1385; 10.1126/science.1059780
• Schwechheimer, Claus and Serino, Giovanna, et el. (2001) Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF^(TIR1) in Mediating Auxin Response; Science; Vol. 292; No. 5520; 1379-1382; 10.1126/science.1059776
• Galan, Jean-Marc and Wiederkehr, Andreas, et el. (2001) Skp1p and the F-Box Protein Rcy1p Form a Non-SCF Complex Involved in Recycling of the SNARE Snc1p in Yeast; Molecular and Cellular Biology; Vol. 21; No. 9; 3105-3117; PMCID PMC86938; 10.1128/MCB.21.9.3105-3117.2001
• Seol, Jae Hong and Shevchenko, Anna, et el. (2001) Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly; Nature Cell Biology; Vol. 3; No. 4; 384-391; 10.1038/35070067
• Annan, Roland S. and Huddleston, Michael J., et el. (2001) A Multidimensional Electrospray MS-Based Approach to Phosphopeptide Mapping; Analytical Chemistry; Vol. 73; No. 3; 393-404; 10.1021/ac001130t
• Verma, Rati and Chen, Stephen, et el. (2000) Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes; Molecular Biology of the Cell; Vol. 11; No. 10; 3425-3439; PMCID PMC15004
• Reynard, Gregory J. and Reynolds, William, et el. (2000) Cks1 Is Required for G1 Cyclin-Cyclin-Dependent Kinase Activity in Budding Yeast; Molecular and Cellular Biology; Vol. 20; No. 16; 5858-5864; PMCID PMC86063
• Deshaies, Raymond J. and Meyerowitz, Elliot M. (2000) COP1 patrols the night beat; Nature Cell Biology; Vol. 2; No. 6; E102-E104; 10.1038/35014095
• Deshaies, R. J. (1999) SCF and Cullin/RING H2-based ubiquitin ligases; Annual Review of Cell and Developmental Biology; Vol. 15; 435-467; 10.1146/annurev.cellbio.15.1.435
• Lyapina, Svetlana A. and Correll, Craig C., et el. (1998) Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 13; 7451-7456; PMCID PMC22647
• Verma, R. and Annan, R. S., et el. (1997) Phosphorylation of Sic1p by G_1 Cdk Required for Its Degradation and Entry into S Phase; Science; Vol. 278; No. 5337; 455-460; 10.1126/science.278.5337.455
• Verma, Rati and Feldman, R. M. Renny, et el. (1997) SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities; Molecular Biology of the Cell; Vol. 8; No. 8; 1427-1437; PMCID PMC276167
• King, Randall W. and Deshaies, Raymond J., et el. (1996) How Proteolysis Drives the Cell Cycle; Science; Vol. 274; No. 5293; 1652-1659; 10.1126/science.274.5293.1652
• Banerjee, Amit and Deshaies, Raymond J., et el. (1995) Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34; Journal of Biological Chemistry; Vol. 270; No. 44; 26209-26215