Dougherty, Dennis
Haloi, Nandan and Huang, Shan, et el. (2024) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids ; Protein Engineering, Design and Selection; Vol. 37; gzae003; PMCID PMC10896302; 10.1093/protein/gzae003
Walker, Noah B. and Yan, Yijin, et el. (2023) β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats ; eNeuro; Vol. 10; No. 5; Art. No. ENEURO.0449-22.2023; PMCID PMC10216253; 10.1523/eneuro.0449-22.2023
Nichols, Aaron L. and Blumenfeld, Zack, et el. (2023) Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane ; Journal of Neuroscience; Vol. 43; No. 13; 2222-2241; PMCID PMC10072302; 10.1523/jneurosci.1519-22.2022
Lummis, Sarah C. R. and Dougherty, Dennis A. (2022) Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues ; Membranes; Vol. 12; No. 10; Art. No. 1012; PMCID PMC9607081; 10.3390/membranes12101012
Knox, Hailey J. and Rego Campello, Hugo, et el. (2022) Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor ; Journal of the American Chemical Society; Vol. 144; No. 35; 16101-16117; 10.1021/jacs.2c06495
Mocatta, James and Mesoy, Susanne M., et el. (2022) 5-HT₃ Receptor MX Helix Contributes to Receptor Function ; ACS Chemical Neuroscience; Vol. 13; No. 15; 2338-2345; PMCID PMC9354082; 10.1021/acschemneuro.2c00339
Muthusamy, Anand K. and Kim, Charlene H., et el. (2022) Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids ; Journal of the American Chemical Society; Vol. 144; No. 19; 8480-8486; PMCID PMC9121368; 10.1021/jacs.2c02323
Nichols, Aaron L. and Blumenfeld, Zack, et el. (2022) Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands ; eLife; Vol. 11; Art. No. e74648; PMCID PMC8820738; 10.7554/eLife.74648
Baker, Benjamin W. and Dougherty, Dennis A., et el. (2020) Proline Residues Contribute to Efficient GABAp Receptor Function ; ACS Chemical Neuroscience; Vol. 11; No. 24; 4215-4222; 10.1021/acschemneuro.0c00483
Blom, Annet E. M. and Su, Justin Y., et el. (2020) Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABA_A Receptor ; ACS Medicinal Chemistry Letters; Vol. 11; No. 11; 2204-2211; PMCID PMC7667864; 10.1021/acsmedchemlett.0c00340
Lester, Henry A. and Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem ; Neuron; Vol. 104; No. 3; 431-432; 10.1016/j.neuron.2019.10.029
Blom, Annet E. M. and Rego Campello, Hugo, et el. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor ; Journal of the American Chemical Society; Vol. 141; No. 40; 15840-15849; 10.1021/jacs.9b06580
Blunt, Catriona E. W. and Dougherty, Dennis A. (2019) Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor ; Molecular Pharmacology; Vol. 96; No. 2; 212-218; 10.1124/mol.119.116244
Mosesso, Richard and Dougherty, Dennis A., et el. (2019) Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT_3 and nACh Receptors ; ACS Chemical Neuroscience; Vol. 10; No. 7; 3327-3333; 10.1021/acschemneuro.9b00315
Shivange, Amol V. and Borden, Philip M., et el. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors ; Journal of General Physiology; Vol. 151; No. 6; 738-757; PMCID PMC6571994; 10.1085/jgp.201812201
Jarman, John B. and Dougherty, Dennis A. (2019) Charge-transfer heptamethine dyes for NIR singlet oxygen generation ; Chemical Communications; Vol. 55; No. 38; 5511-5514; 10.1039/c9cc01096c
Walton, David P. and Dougherty, Dennis A. (2019) A general strategy for visible-light decaging based on the quinone cis-alkenyl lock ; Chemical Communications; Vol. 55; No. 34; 4965-4968; 10.1039/c9cc01073d
Dougherty, Dennis (2019) James Flack Norris Award in Physical Organic Chemistry: Eric V. Anslyn ; Chemical and Engineering News; Vol. 97; No. 3; 38-39
Dougherty, Dennis A. (2019) Francis P. Garvan John M. Olin Medal: Lisa McElwee-White ; Chemical & Engineering News; Vol. 97; No. 3; 47
Henderson, Brandon J. and Grant, Stephen, et el. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing ; eNeuro; Vol. 5; No. 6; Art. No. e0465-18.2018; PMCID PMC6325563; 10.1523/eneuro.0465-18.2018
Houk, K. N. and Caserio, Marjorie C., et el. (2018) J. D. Roberts Special Issue ; Journal of Physical Organic Chemistry; Vol. 31; No. 8; Art. No. e3886; 10.1002/poc.3886
Mosesso, Richard and Dougherty, Dennis A., et el. (2018) Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC ; Biochemistry; Vol. 57; No. 27; 4036-4043; 10.1021/acs.biochem.8b00379
Mosesso, Richard and Dougherty, Dennis A. (2018) A triad of residues is functionally transferrable between 5-HT_3 serotonin receptors and nicotinic acetylcholine receptors ; Journal of Biological Chemistry; Vol. 293; No. 8; 2903-2914; PMCID PMC5827437; 10.1074/jbc.M117.810432
Lummis, Sarah C. and Mosesso, Richard, et el. (2018) The Pros of nACh and 5-HT_3 Receptors ; Biophysical Journal; Vol. 114; No. 3; 299A-300A; 10.1016/j.bpj.2017.11.1708
Walton, David P. and Dougherty, Dennis A. (2017) A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock ; Journal of the American Chemical Society; Vol. 139; No. 13; 4655-4658; 10.1021/jacs.7b01548
Regan, Clinton J. and Walton, David P., et el. (2017) Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process ; Journal of the American Chemical Society; Vol. 139; No. 13; 4729-4736; 10.1021/jacs.6b12007
Post, Michael R. and Lester, Henry A., et el. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors ; Biochemistry; Vol. 56; No. 13; 1836-1840; PMCID PMC6075822; 10.1021/acs.biochem.7b00213
Post, Michael R. and Tender, Gabrielle S., et el. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors ; eNeuro; Vol. 4; No. 2; Art. No. 0032-17; PMCID PMC5458768; 10.1523/ENEURO.0032-17.2017
Shafaat, Oliver S. and Winkler, Jay R., et el. (2016) Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain ; ChemBioChem; Vol. 17; No. 14; 1323-1327; PMCID PMC5147428; 10.1002/cbic.201600230
Nichols, Weston A. and Henderson, Brandon J., et el. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression ; PLoS ONE; Vol. 11; No. 6; Art. No. e0158032; PMCID PMC4918917; 10.1371/journal.pone.0158032
Rienzo, Matthew and Rocchi, Angela R., et el. (2016) Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-Gated Ion Channel (GLIC) Supports Conserved Gating Motions Among Cys-Loop Receptors ; Journal of Biological Chemistry; Vol. 291; No. 12; 6272-6280; PMCID PMC4813548; 10.1074/jbc.M115.694372
Tender, Gabrielle S. and Dougherty, Dennis A., et el. (2016) Probing Molecular Interactions in Erwinia Ligand-Gated Ion Channel (ELIC) ; Biophysical Journal; Vol. 110; No. 3; 457A; 10.1016/j.bpj.2015.11.2449
Walton, David P. and Regan, Clinton J., et el. (2016) Visible-Light Absorbing, Photolabile, Quinone-Based Protecting Groups for Alcohols and Amines ; Biophysical Journal; Vol. 110; No. 3; 455A; 10.1016/j.bpj.2015.11.2440
Rienzo, Matthew and Rocchi, Angela R., et el. (2016) Insights into Gating Motions of GLIC via Perturbation of Critical Prolines with Non-Canonical Amino Acid Probes ; Biophysical Journal; Vol. 110; No. 3; 456A; 10.1016/j.bpj.2015.11.2443
Post, Michael R. and Dougherty, Dennis A., et el. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor ; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3220
Davis, Matthew R. and Dougherty, Dennis A. (2016) Cation-π Interactions: Computational Analyses of the Aromatic Box Motif and the Fluorination Strategy for Experimental Evaluation of Cys-Loop Receptors and Related Structures ; Biophysical Journal; Vol. 110; No. 3; 454A; 10.1016/j.bpj.2015.11.2434
Davis, Matthew R. and Dougherty, Dennis A. (2015) Cation–π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation ; Physical Chemistry Chemical Physics; Vol. 17; No. 43; 29262-29270; PMCID PMC4627595; 10.1039/C5CP04668H
Lester, Henry A. and Lavis, Luke D., et el. (2015) Ketamine Inside Neurons? ; American Journal of Psychiatry; Vol. 172; No. 11; 1064-1066; PMCID PMC6107348; 10.1176/appi.ajp.2015.14121537
Post, Michael R. and Limapichat, Walrati, et el. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors ; Neuropharmacology; Vol. 97; 376-382; PMCID PMC4635625; 10.1016/j.neuropharm.2015.04.009
Marotta, Christopher B. and Lester, Henry A., et el. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors ; Chemistry and Biology; Vol. 22; No. 8; 1063-1073; PMCID PMC4547686; 10.1016/j.chembiol.2015.06.018
Yue, Lan and Walston, Sean, et el. (2015) Imaging Novel Ruthenium bipyridine-based Nanophotoswitches in Retina ; Investigative ophthalmology & visual science; Vol. 56; No. 7; 1676-1676
Wieskopf, Jeffrey S. and Limapichat, Walrati, et el. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors ; Science Translational Medicine; Vol. 7; No. 287; Art. No. 287ra72; PMCID PMC5018401; 10.1126/scitranslmed.3009986
Miles, Timothy F. and Lester, Henry A., et el. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG ; Neuropharmacology; Vol. 91; 103-108; PMCID PMC4312754; 10.1016/j.neuropharm.2014.12.018
Shafaat, Oliver S. and Rusinova, Radda, et el. (2015) Reconstitution and in-vitro activation of the prokaryotic pentameric ligand-gated ion channel ELIC ; Abstracts of Papers of the American Chemical Society; Vol. 249; BIOL-246
Rienzo, Matthew and Lummis, Sarah C. R., et el. (2014) Structural Requirements in the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical Histidine Analogs ; Chemistry and Biology; Vol. 21; No. 12; 1700-1706; PMCID PMC4291181; 10.1016/j.chembiol.2014.10.019
Daeffler, Kristina N.-M. and Lester, Henry A., et el. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl ; ACS Chemical Biology; Vol. 9; No. 10; 2283-2290; PMCID PMC4201344; 10.1021/cb500323d
Limapichat, Walrati and Dougherty, Dennis A., et el. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors ; Molecular Pharmacology; Vol. 86; No. 3; 263-274; PMCID PMC4152909; 10.1124/mol.114.093179
Dougherty, Dennis A. and Van Arnam, Ethan B. (2014) In Vivo Incorporation of Non-canonical Amino Acids by Using the Chemical Aminoacylation Strategy: A Broadly Applicable Mechanistic Tool ; ChemBioChem; Vol. 15; No. 12; 1710-1720; PMCID PMC4155927; 10.1002/cbic.201402080
Van Arnam, Ethan B. and Dougherty, Dennis A. (2014) Functional Probes of Drug−Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground ; Journal of Medicinal Chemistry; Vol. 57; No. 15; 6289-6300; PMCID PMC4136689; 10.1021/jm500023m
Marotta, Christopher B. and Rreza, Iva, et el. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors ; ACS Chemical Biology; Vol. 9; No. 5; 1153-1159; PMCID PMC4033646; 10.1021/cb400937d
Shafaat, O. S. and Winkler, J. R., et el. (2014) Ion Channel Dynamics: Physical monitoring of the gating event using electrophysiology and time-resolved spectroscopy ; Journal of Biological Inorganic Chemistry; Vol. 19; No. Supplement1; S583; 10.1007/s00775-014-1095-8
Marotta, Christopher B. and Dilworth, Crystal N., et el. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor ; Neuropharmacology; Vol. 77; 342-349; PMCID PMC3934363; 10.1016/j.neuropharm.2013.09.028
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Post, Michael R. and Lester, Henry A., et el. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes ; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1950
Miles, Timothy F. and Dougherty, Dennis A., et el. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane ; Biophysical Journal; Vol. 105; No. 4; 887-898; PMCID PMC3752109; 10.1016/j.bpj.2013.07.015
Van Arnam, Ethan B. and Blythe, Emily E., et el. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline ; Molecular Pharmacology; Vol. 84; No. 2; 201-207; PMCID PMC3716316; 10.1124/mol.113.085795
Dougherty, Dennis A. (2013) The Cation-π Interaction ; Accounts of Chemical Research; Vol. 46; No. 4; 885-893; PMCID PMC3957424; 10.1021/ar300265y
Blum, Angela P. and Van Arnam, Ethan B., et el. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors ; Journal of Biological Chemistry; Vol. 288; No. 10; 6991-6997; PMCID PMC3591609; 10.1074/jbc.M112.439968
Limapichat, Walrati and Yu, Wesley Y., et el. (2013) Key Binding Interactions for Memantine in the NMDA Receptor ; ACS Chemical Neuroscience; Vol. 4; No. 2; 255-260; PMCID PMC3751542; 10.1021/cn300180a
Liu, Fan and Abrol, Ravinder, et el. (2013) Conformational Entropic Maps of Functional Coupling Domains in GPCR Activation: A Case Study of β2 Adrenergic Receptor ; Biophysical Journal; Vol. 104; No. 2; 537A; 10.1016/j.bpj.2012.11.2975
Ashby, Jamie A. and McGonigle, Ian V., et el. (2012) GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study ; Biophysical Journal; Vol. 103; No. 10; 2071-2081; PMCID PMC3512037; 10.1016/j.bpj.2012.10.016
Spurny, Radovan and Ramerstorfer, Joachim, et el. (2012) Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines ; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 44; E3028-E3034; PMCID PMC3497736; 10.1073/pnas.1208208109
Miles, Timothy F. and Bower, Kiowa S., et el. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way ; ACS Chemical Neuroscience; Vol. 3; No. 10; 753-760; PMCID PMC3474281; 10.1021/cn3000586
Duffy, Noah H. and Lester, Henry A., et el. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3
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Srinivasan, Rahul and Richards, Christopher I., et el. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2 ; International Journal of Molecular Sciences; Vol. 13; No. 8; 10022-10040; PMCID PMC3431844; 10.3390/ijms130810022
Tavares, Ximena Da Silva and Blum, Angela P., et el. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor ; Journal of the American Chemical Society; Vol. 134; No. 28; 11474-11480; PMCID PMC3399941; 10.1021/ja3011379
Richards, Christopher I. and Luong, Khai, et el. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures ; Nano Letters; Vol. 12; No. 7; 3690-3694; PMCID PMC3397148; 10.1021/nl301480h
Puskar, Nyssa L. and Lester, Henry A., et el. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor ; ACS Chemical Biology; Vol. 7; No. 5; 841-846; PMCID PMC3356501; 10.1021/cb200448j
Lummis, Sarah C. R. and Harrison, Neil J., et el. (2012) Multiple Tyrosine Residues Contribute to GABA Binding in the
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Blum, Angela P. and Gleitsman, Kristin Rule, et el. (2011) Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit ; Journal of Biological Chemistry; Vol. 286; No. 37; 32251-32258; PMCID PMC3173184; 10.1074/jbc.M111.254235
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Kedrowski, Sean M. A. and Dougherty, Dennis A. (2010) Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates ; Organic Letters; Vol. 12; No. 18; 3990-3993; PMCID PMC2941390; 10.1021/ol1015493
Duffy, Noah H. and Dougherty, Dennis A. (2010) Preparation of Translationally Competent tRNA by Direct Chemical Acylation ; Organic Letters; Vol. 12; No. 17; 3776-3779; PMCID PMC2929286; 10.1021/ol101408f
Blum, Angela P. and Lester, Henry A., et el. (2010) Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH ; Proceedings of the National Academy of Sciences of the United States of America; Vol. 107; No. 30; 13206-13211; PMCID PMC2922130; 10.1073/pnas.1007140107
Hanek, Ariele P. and Lester, Henry A., et el. (2010) Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation ; Molecular Pharmacology; Vol. 78; No. 1; 29-35; PMCID PMC2912059; 10.1124/mol.109.059832
Tao, Xiao and Lee, Alice, et el. (2010) A Gating Charge Transfer Center in Voltage Sensors ; Science; Vol. 328; No. 5974; 67-73; PMCID PMC2869078; 10.1126/science.1185954
Limapichat, Walrati and Lester, Henry A., et el. (2010) Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys ; Journal of Biological Chemistry; Vol. 285; No. 12; 8976-8984; PMCID PMC2838319; 10.1074/jbc.M109.060939
Eastwood, Amy L. and Blum, Angela P., et el. (2009) A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters ; Journal of Organic Chemistry; Vol. 74; No. 23; 9241-9244; PMCID PMC2953381; 10.1021/jo901368g
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Gleitsman, Kristin R. and Shanata, Jai A. P., et el. (2009) Long-Range Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis ; Biophysical Journal; Vol. 96; No. 8; 3168-3178; PMCID PMC2718292; 10.1016/j.bpj.2008.12.3949
Xiu, Xinan and Puskar, Nyssa L., et el. (2009) Nicotine binding to brain receptors requires a strong cation–π interaction ; Nature; Vol. 458; No. 7237; 534-537; PMCID PMC2755585; 10.1038/nature07768
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Gleitsman, Kristin Rule and Kedrowski, Sean M. A., et el. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating ; Journal of Biological Chemistry; Vol. 283; No. 51; 35638-35643; PMCID PMC2602911; 10.1074/jbc.M807226200
Pless, Stephan A. and Millen, Kat S., et el. (2008) A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue ; Journal of Neuroscience; Vol. 28; No. 43; 10937-10942; PMCID PMC2649377; 10.1523/JNEUROSCI.2540-08.2008
Hanek, Ariele P. and Lester, Henry A., et el. (2008) A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor ; Journal of the American Chemical Society; Vol. 130; No. 40; 13216-13218; 10.1021/ja8015457
Price, Kerry L. and Bower, Kiowa S., et el. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT_3 Receptor ; Biochemistry; Vol. 47; No. 24; 6370-6377; PMCID PMC264937; 10.1021/bi800222n
Maurer, Joshua A. and Elmore, Donald E., et el. (2008) Confirming the Revised C-Terminal Domain of the MscL Crystal Structure ; Biophysical Journal; Vol. 94; No. 12; 4662-4667; PMCID PMC2397327; 10.1529/biophysj.107.127365
Dougherty, Dennis A. (2008) Physical Organic Chemistry on the Brain ; Journal of Organic Chemistry; Vol. 73; No. 10; 3667-3673; 10.1021/jo8001722
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Elmore, Donald E. and Dougherty, Dennis A. (2003) Investigating Lipid Composition Effects on the Mechanosensitive Channel of Large Conductance (MscL) Using Molecular Dynamics Simulations ; Biophysical Journal; Vol. 85; No. 3; 1512-1524; PMCID PMC1303328; 10.1016/s0006-3495(03)74584-6
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Zacharias, Niki and Dougherty, Dennis A. (2002) Cation–π interactions in ligand recognition and catalysis ; Trends in Pharmacological Sciences; Vol. 23; No. 6; 281-287; 10.1016/s0165-6147(02)02027-8
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Elmore, Donald E. and Dougherty, Dennis A. (2001) Molecular Dynamics Simulations of Wild-Type and Mutant Forms of the Mycobacterium tuberculosis MscL Channel ; Biophysical Journal; Vol. 81; No. 3; 1345-1359; PMCID PMC1301615; 10.1016/s0006-3495(01)75791-8
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Dougherty, Dennis A. and Lester, Henry A. (2001) Neurobiology: Snails, synapses and smokers ; Nature; Vol. 411; No. 6835; 252-254; 10.1038/35077192
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Dougherty, D. A. (2001) Polymer stereochemistry: an opportunity and a challenge on Titan ; Enantiomer; Vol. 6; No. 2-3; 101-106
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Elmore, Donald E. and Dougherty, Dennis A. (2000) A Computational Study of Nicotine Conformations in the Gas Phase and in Water ; Journal of Organic Chemistry; Vol. 65; No. 3; 742-747; 10.1021/jo991383q
Gallivan, Justin P. and Dougherty, Dennis A. (2000) A Computational Study of Cation−π Interactions vs Salt Bridges in Aqueous Media: Implications for Protein Engineering ; Journal of the American Chemical Society; Vol. 122; No. 5; 870-874; 10.1021/ja991755c
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Gallivan, Justin P. and Dougherty, Dennis A. (1999) Can Lone Pairs Bind to a π System? The Water···Hexafluorobenzene Interaction ; Organic Letters; Vol. 1; No. 1; 103-106; 10.1021/ol990577p
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Lester, Henry A. and Dougherty, Dennis A. (1998) New Views of Multi-Ion Channels ; Journal of General Physiology; Vol. 111; No. 2; 181-183; PMCID PMC2222761; 10.1085/jgp.111.2.181
Dougherty, Dennis A. (1998) Stereochemical issues in studies of ion channel proteins ; Chirality; Vol. 10; No. 1-2; 8-13; 10.1002/chir.3
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Dougherty, Dennis A. (1997) Physical organic chemistry in the brain ; Pure and Applied Chemistry; Vol. 69; No. 9; 1969-1978; 10.1351/pac199769091969
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Winstead, Meldrum B. and Dougherty, Dennis A., et el. (1978) Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters ; Journal of Medicinal Chemistry; Vol. 21; No. 2; 215-217; 10.1021/jm00200a014
