Dougherty, Dennis

Combined from CaltechAUTHORS

• Haloi, Nandan and Huang, Shan, et el. (2024) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids; Protein Engineering, Design and Selection; Vol. 37; gzae003; PMCID PMC10896302; 10.1093/protein/gzae003
• Walker, Noah B. and Yan, Yijin, et el. (2023) β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats; eNeuro; Vol. 10; No. 5; Art. No. ENEURO.0449-22.2023; PMCID PMC10216253; 10.1523/eneuro.0449-22.2023
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2023) Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane; Journal of Neuroscience; Vol. 43; No. 13; 2222-2241; PMCID PMC10072302; 10.1523/jneurosci.1519-22.2022
• Haloi, Nandan and Huang, Shan, et el. (2023) Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids; 10.1101/2023.01.16.524298
• Lummis, Sarah C. R. and Dougherty, Dennis A. (2022) Expression of Mutant Glycine Receptors in Xenopus Oocytes Using Canonical and Non-Canonical Amino Acids Reveals Distinct Roles of Conserved Proline Residues; Membranes; Vol. 12; No. 10; Art. No. 1012; PMCID PMC9607081; 10.3390/membranes12101012
• Knox, Hailey J. and Rego Campello, Hugo, et el. (2022) Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 144; No. 35; 16101-16117; 10.1021/jacs.2c06495
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2022) Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane; 10.1101/2022.08.09.502705
• Mocatta, James and Mesoy, Susanne M., et el. (2022) 5-HT₃ Receptor MX Helix Contributes to Receptor Function; ACS Chemical Neuroscience; Vol. 13; No. 15; 2338-2345; PMCID PMC9354082; 10.1021/acschemneuro.2c00339
• Muthusamy, Anand K. and Kim, Charlene H., et el. (2022) Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids; Journal of the American Chemical Society; Vol. 144; No. 19; 8480-8486; PMCID PMC9121368; 10.1021/jacs.2c02323
• Nichols, Aaron L. and Blumenfeld, Zack, et el. (2022) Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands; eLife; Vol. 11; Art. No. e74648; PMCID PMC8820738; 10.7554/eLife.74648
• Baker, Benjamin W. and Dougherty, Dennis A., et el. (2020) Proline Residues Contribute to Efficient GABAp Receptor Function; ACS Chemical Neuroscience; Vol. 11; No. 24; 4215-4222; 10.1021/acschemneuro.0c00483
• Blom, Annet E. M. and Su, Justin Y., et el. (2020) Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABA_A Receptor; ACS Medicinal Chemistry Letters; Vol. 11; No. 11; 2204-2211; PMCID PMC7667864; 10.1021/acsmedchemlett.0c00340
• Cohen, Bruce N. and Nichols, Aaron L., et el. (2020) Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients; 10.32388/WURFH0
• Lester, Henry A. and Dougherty, Dennis A. (2019) Nicotine Bound to Its Receptors: New Structures for a Vexing Pathopharmacological Problem; Neuron; Vol. 104; No. 3; 431-432; 10.1016/j.neuron.2019.10.029
• Blom, Annet E. M. and Rego Campello, Hugo, et el. (2019) Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 141; No. 40; 15840-15849; 10.1021/jacs.9b06580
• Blunt, Catriona E. W. and Dougherty, Dennis A. (2019) Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor; Molecular Pharmacology; Vol. 96; No. 2; 212-218; 10.1124/mol.119.116244
• Mosesso, Richard and Dougherty, Dennis A., et el. (2019) Proline Residues in the Transmembrane/Extracellular Domain Interface Loops Have Different Behaviors in 5-HT_3 and nACh Receptors; ACS Chemical Neuroscience; Vol. 10; No. 7; 3327-3333; 10.1021/acschemneuro.9b00315
• Shivange, Amol V. and Borden, Philip M., et el. (2019) Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors; Journal of General Physiology; Vol. 151; No. 6; 738-757; PMCID PMC6571994; 10.1085/jgp.201812201
• Jarman, John B. and Dougherty, Dennis A. (2019) Charge-transfer heptamethine dyes for NIR singlet oxygen generation; Chemical Communications; Vol. 55; No. 38; 5511-5514; 10.1039/c9cc01096c
• Walton, David P. and Dougherty, Dennis A. (2019) A general strategy for visible-light decaging based on the quinone cis-alkenyl lock; Chemical Communications; Vol. 55; No. 34; 4965-4968; 10.1039/c9cc01073d
• Dougherty, Dennis (2019) James Flack Norris Award in Physical Organic Chemistry: Eric V. Anslyn; Chemical and Engineering News; Vol. 97; No. 3; 38-39
• Dougherty, Dennis A. (2019) Francis P. Garvan John M. Olin Medal: Lisa McElwee-White; Chemical & Engineering News; Vol. 97; No. 3; 47
• Henderson, Brandon J. and Grant, Stephen, et el. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing; eNeuro; Vol. 5; No. 6; Art. No. e0465-18.2018; PMCID PMC6325563; 10.1523/eneuro.0465-18.2018
• Houk, K. N. and Caserio, Marjorie C., et el. (2018) J. D. Roberts Special Issue; Journal of Physical Organic Chemistry; Vol. 31; No. 8; Art. No. e3886; 10.1002/poc.3886
• Mosesso, Richard and Dougherty, Dennis A., et el. (2018) Probing Proline Residues in the Prokaryotic Ligand-Gated Ion Channel, ELIC; Biochemistry; Vol. 57; No. 27; 4036-4043; 10.1021/acs.biochem.8b00379
• Mosesso, Richard and Dougherty, Dennis A. (2018) A triad of residues is functionally transferrable between 5-HT_3 serotonin receptors and nicotinic acetylcholine receptors; Journal of Biological Chemistry; Vol. 293; No. 8; 2903-2914; PMCID PMC5827437; 10.1074/jbc.M117.810432
• Lummis, Sarah C. and Mosesso, Richard, et el. (2018) The Pros of nACh and 5-HT_3 Receptors; Biophysical Journal; Vol. 114; No. 3; 299A-300A; 10.1016/j.bpj.2017.11.1708
• Dougherty, Dennis A. (2017) The cation-π interaction; ISBN 978-1-78262-173-7; Intermolecular Interactions in Crystals: Fundamentals of Crystal Engineering; 516-529
• Walton, David P. and Dougherty, Dennis A. (2017) A General Strategy for Visible-Light Decaging Based on the Quinone Trimethyl Lock; Journal of the American Chemical Society; Vol. 139; No. 13; 4655-4658; 10.1021/jacs.7b01548
• Regan, Clinton J. and Walton, David P., et el. (2017) Mechanistic Studies of the Photoinduced Quinone Trimethyl Lock Decaging Process; Journal of the American Chemical Society; Vol. 139; No. 13; 4729-4736; 10.1021/jacs.6b12007
• Post, Michael R. and Lester, Henry A., et el. (2017) Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors; Biochemistry; Vol. 56; No. 13; 1836-1840; PMCID PMC6075822; 10.1021/acs.biochem.7b00213
• Post, Michael R. and Tender, Gabrielle S., et el. (2017) Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors; eNeuro; Vol. 4; No. 2; Art. No. 0032-17; PMCID PMC5458768; 10.1523/ENEURO.0032-17.2017
• Shafaat, Oliver S. and Winkler, Jay R., et el. (2016) Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain; ChemBioChem; Vol. 17; No. 14; 1323-1327; PMCID PMC5147428; 10.1002/cbic.201600230
• Nichols, Weston A. and Henderson, Brandon J., et el. (2016) Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression; PLoS ONE; Vol. 11; No. 6; Art. No. e0158032; PMCID PMC4918917; 10.1371/journal.pone.0158032
• Rienzo, Matthew and Rocchi, Angela R., et el. (2016) Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-Gated Ion Channel (GLIC) Supports Conserved Gating Motions Among Cys-Loop Receptors; Journal of Biological Chemistry; Vol. 291; No. 12; 6272-6280; PMCID PMC4813548; 10.1074/jbc.M115.694372
• Regan, Clinton and Walton, David, et el. (2016) Photorelease of biologically relevant molecules using near-IR light
• Post, Michael R. and Lester, Henry, et el. (2016) Probing binding interactions of agonists at a nicotinic acetylcholine receptor subtype important to addiction and Parkinson's disease
• Davis, Matthew R. and Dougherty, Dennis A. (2016) Cation-π interactions: Computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation of cys-loop receptors and related structures
• Mosesso, Richard and Lummis, Sarah C. R., et el. (2016) Natural and non-canonical mutagenesis studies of receptor gating in 5-HT3A receptors
• Rienzo, Matthew and Rocchi, Angela, et el. (2016) Non-canonical proline analogs reveal mechanistic trends among GLIC and other ligand-gated ion channels
• Davis, Matthew R. and Dougherty, Dennis A. (2016) Cation-π Interactions: Computational Analyses of the Aromatic Box Motif and the Fluorination Strategy for Experimental Evaluation of Cys-Loop Receptors and Related Structures; Biophysical Journal; Vol. 110; No. 3; 454A; 10.1016/j.bpj.2015.11.2434
• Post, Michael R. and Dougherty, Dennis A., et el. (2016) Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor; Biophysical Journal; Vol. 110; No. 3; 603A; 10.1016/j.bpj.2015.11.3220
• Rienzo, Matthew and Rocchi, Angela R., et el. (2016) Insights into Gating Motions of GLIC via Perturbation of Critical Prolines with Non-Canonical Amino Acid Probes; Biophysical Journal; Vol. 110; No. 3; 456A; 10.1016/j.bpj.2015.11.2443
• Walton, David P. and Regan, Clinton J., et el. (2016) Visible-Light Absorbing, Photolabile, Quinone-Based Protecting Groups for Alcohols and Amines; Biophysical Journal; Vol. 110; No. 3; 455A; 10.1016/j.bpj.2015.11.2440
• Tender, Gabrielle S. and Dougherty, Dennis A., et el. (2016) Probing Molecular Interactions in Erwinia Ligand-Gated Ion Channel (ELIC); Biophysical Journal; Vol. 110; No. 3; 457A; 10.1016/j.bpj.2015.11.2449
• Davis, Matthew R. and Dougherty, Dennis A. (2015) Cation–π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation; Physical Chemistry Chemical Physics; Vol. 17; No. 43; 29262-29270; PMCID PMC4627595; 10.1039/C5CP04668H
• Lester, Henry A. and Lavis, Luke D., et el. (2015) Ketamine Inside Neurons?; American Journal of Psychiatry; Vol. 172; No. 11; 1064-1066; PMCID PMC6107348; 10.1176/appi.ajp.2015.14121537
• Dougherty, Dennis A. (2015) Computational studies of cation-π interactions and applications to neuroscience
• Post, Michael R. and Limapichat, Walrati, et el. (2015) Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors; Neuropharmacology; Vol. 97; 376-382; PMCID PMC4635625; 10.1016/j.neuropharm.2015.04.009
• Marotta, Christopher B. and Lester, Henry A., et el. (2015) An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors; Chemistry and Biology; Vol. 22; No. 8; 1063-1073; PMCID PMC4547686; 10.1016/j.chembiol.2015.06.018
• Yue, Lan and Walston, Sean, et el. (2015) Imaging Novel Ruthenium bipyridine-based Nanophotoswitches in Retina; Investigative ophthalmology & visual science; Vol. 56; No. 7; 1676-1676
• Wieskopf, Jeffrey S. and Limapichat, Walrati, et el. (2015) The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors; Science Translational Medicine; Vol. 7; No. 287; Art. No. 287ra72; PMCID PMC5018401; 10.1126/scitranslmed.3009986
• Miles, Timothy F. and Lester, Henry A., et el. (2015) Allosteric activation of the 5-HT_3AB receptor by mCPBG; Neuropharmacology; Vol. 91; 103-108; PMCID PMC4312754; 10.1016/j.neuropharm.2014.12.018
• Shafaat, Oliver S. and Rusinova, Radda, et el. (2015) Reconstitution and in-vitro activation of the prokaryotic pentameric ligand-gated ion channel ELIC; Abstracts of Papers of the American Chemical Society; Vol. 249; BIOL-246
• Rienzo, Matthew and Lummis, Sarah C. R., et el. (2014) Structural Requirements in the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical Histidine Analogs; Chemistry and Biology; Vol. 21; No. 12; 1700-1706; PMCID PMC4291181; 10.1016/j.chembiol.2014.10.019
• Daeffler, Kristina N.-M. and Lester, Henry A., et el. (2014) Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl; ACS Chemical Biology; Vol. 9; No. 10; 2283-2290; PMCID PMC4201344; 10.1021/cb500323d
• Limapichat, Walrati and Dougherty, Dennis A., et el. (2014) Subtype-Specific Mechanisms for Functional Interaction between α6β4* Nicotinic Acetylcholine Receptors and P2X Receptors; Molecular Pharmacology; Vol. 86; No. 3; 263-274; PMCID PMC4152909; 10.1124/mol.114.093179
• Dougherty, Dennis A. and Van Arnam, Ethan B. (2014) In Vivo Incorporation of Non-canonical Amino Acids by Using the Chemical Aminoacylation Strategy: A Broadly Applicable Mechanistic Tool; ChemBioChem; Vol. 15; No. 12; 1710-1720; PMCID PMC4155927; 10.1002/cbic.201402080
• Van Arnam, Ethan B. and Dougherty, Dennis A. (2014) Functional Probes of Drug−Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground; Journal of Medicinal Chemistry; Vol. 57; No. 15; 6289-6300; PMCID PMC4136689; 10.1021/jm500023m
• Marotta, Christopher B. and Rreza, Iva, et el. (2014) Selective Ligand Behaviors Provide New Insights into Agonist Activation of Nicotinic Acetylcholine Receptors; ACS Chemical Biology; Vol. 9; No. 5; 1153-1159; PMCID PMC4033646; 10.1021/cb400937d
• Shafaat, O. S. and Winkler, J. R., et el. (2014) Ion Channel Dynamics: Physical monitoring of the gating event using electrophysiology and time-resolved spectroscopy; Journal of Biological Inorganic Chemistry; Vol. 19; No. Supplement1; S583; 10.1007/s00775-014-1095-8
• Marotta, Christopher B. and Dilworth, Crystal N., et el. (2014) Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor; Neuropharmacology; Vol. 77; 342-349; PMCID PMC3934363; 10.1016/j.neuropharm.2013.09.028
• Rienzo, Matthew and Shafaat, Oliver S., et el. (2014) Prokaryotic Cys-Loop Receptor Homologs as Mechanistic Models for Channel Function; Biophysical Journal; Vol. 106; No. 2; 545A; 10.1016/j.bpj.2013.11.3037
• Post, Michael R. and Lester, Henry A., et el. (2014) Structure Function Studies at Two Different Nicotinic Acetylcholine Receptor Subtypes; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1950
• Marotta, Christopher and Lester, Henry A., et el. (2014) Identifying Motifs Essential for Selective Activation of Nicotinic Acetylcholine Receptors; Biophysical Journal; Vol. 106; No. 2; 341A; 10.1016/j.bpj.2013.11.1951
• Miles, Timothy F. and Dougherty, Dennis A., et el. (2013) The 5-HT_3AB Receptor Shows an A_3B_2 Stoichiometry at the Plasma Membrane; Biophysical Journal; Vol. 105; No. 4; 887-898; PMCID PMC3752109; 10.1016/j.bpj.2013.07.015
• Van Arnam, Ethan B. and Blythe, Emily E., et el. (2013) An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline; Molecular Pharmacology; Vol. 84; No. 2; 201-207; PMCID PMC3716316; 10.1124/mol.113.085795
• Dougherty, Dennis A. (2013) The Cation-π Interaction; Accounts of Chemical Research; Vol. 46; No. 4; 885-893; PMCID PMC3957424; 10.1021/ar300265y
• Blum, Angela P. and Van Arnam, Ethan B., et el. (2013) Binding Interactions with the Complementary Subunit of Nicotinic Receptors; Journal of Biological Chemistry; Vol. 288; No. 10; 6991-6997; PMCID PMC3591609; 10.1074/jbc.M112.439968
• Limapichat, Walrati and Yu, Wesley Y., et el. (2013) Key Binding Interactions for Memantine in the NMDA Receptor; ACS Chemical Neuroscience; Vol. 4; No. 2; 255-260; PMCID PMC3751542; 10.1021/cn300180a
• Liu, Fan and Abrol, Ravinder, et el. (2013) Conformational Entropic Maps of Functional Coupling Domains in GPCR Activation: A Case Study of β2 Adrenergic Receptor; Biophysical Journal; Vol. 104; No. 2; 537A; 10.1016/j.bpj.2012.11.2975
• Ashby, Jamie A. and McGonigle, Ian V., et el. (2012) GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study; Biophysical Journal; Vol. 103; No. 10; 2071-2081; PMCID PMC3512037; 10.1016/j.bpj.2012.10.016
• Spurny, Radovan and Ramerstorfer, Joachim, et el. (2012) Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 44; E3028-E3034; PMCID PMC3497736; 10.1073/pnas.1208208109
• Miles, Timothy F. and Bower, Kiowa S., et el. (2012) A Coupled Array of Noncovalent Interactions Impacts the Function of the 5‑HT_3A Serotonin Receptor in an Agonist-Specific Way; ACS Chemical Neuroscience; Vol. 3; No. 10; 753-760; PMCID PMC3474281; 10.1021/cn3000586
• Duffy, Noah H. and Lester, Henry A., et el. (2012) Ondansetron and Granisetron Binding Orientation in the 5‑HT_3 Receptor Determined by Unnatural Amino Acid Mutagenesis; ACS Chemical Biology; Vol. 7; No. 10; 1738-1745; PMCID PMC3477246; 10.1021/cb300246j
• Daeffler, Kristina N.-M. and Lester, Henry A., et el. (2012) Functionally Important Aromatic–Aromatic and Sulfur−π Interactions in the D2 Dopamine Receptor; Journal of the American Chemical Society; Vol. 134; No. 36; 14890-14896; PMCID PMC3461201; 10.1021/ja304560x
• Srinivasan, Rahul and Richards, Christopher I., et el. (2012) Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2; International Journal of Molecular Sciences; Vol. 13; No. 8; 10022-10040; PMCID PMC3431844; 10.3390/ijms130810022
• Tavares, Ximena Da Silva and Blum, Angela P., et el. (2012) Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor; Journal of the American Chemical Society; Vol. 134; No. 28; 11474-11480; PMCID PMC3399941; 10.1021/ja3011379
• Richards, Christopher I. and Luong, Khai, et el. (2012) Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures; Nano Letters; Vol. 12; No. 7; 3690-3694; PMCID PMC3397148; 10.1021/nl301480h
• Puskar, Nyssa L. and Lester, Henry A., et el. (2012) Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor; ACS Chemical Biology; Vol. 7; No. 5; 841-846; PMCID PMC3356501; 10.1021/cb200448j
• Lummis, Sarah C. R. and Harrison, Neil J., et el. (2012) Multiple Tyrosine Residues Contribute to GABA Binding in the GABA_C Receptor Binding Pocket; ACS Chemical Neuroscience; Vol. 3; No. 3; 186-192; PMCID PMC3309607; 10.1021/cn200103n
• Srinivasan, Rahul and Richards, Christopher I., et el. (2012) Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response; Molecular Pharmacology; Vol. 81; No. 6; 759-769; PMCID PMC3362896; 10.1124/mol.112.077792
• Van Arnam, Ethan B. and Lester, Henry A., et el. (2011) Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor; ACS Chemical Biology; Vol. 6; No. 10; 1063-1068; PMCID PMC3199346; 10.1021/cb200153g
• Blum, Angela P. and Gleitsman, Kristin Rule, et el. (2011) Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Role of the Vicinal Disulfide of the α1 Subunit; Journal of Biological Chemistry; Vol. 286; No. 37; 32251-32258; PMCID PMC3173184; 10.1074/jbc.M111.254235
• Lummis, Sarah C. R. and McGonigle, Ian, et el. (2011) Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor; Journal of Neuroscience; Vol. 31; No. 34; 12371-12376; PMCID PMC3233689; 10.1523/JNEUROSCI.1610-11.2011
• Puskar, Nyssa L. and Xiu, Xinan, et el. (2011) Two Neuronal Nicotinic Acetylcholine Receptors, α4β4 and α7, Show Differential Agonist Binding Modes; Journal of Biological Chemistry; Vol. 286; No. 16; 14618-14627; PMCID PMC3077659; 10.1074/jbc.M110.206565
• Pless, Stephan A. and Hanek, Ariele P., et el. (2011) A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site Is Conserved for Different Agonists; Molecular Pharmacology; Vol. 79; No. 4; 742-748; PMCID PMC3063724; 10.1124/mol.110.069583
• Shanata, Jai A. P. and Frazier, Shawnalea J., et el. (2011) Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors; ISBN 9781617793332; Allostery: Methods and Protocols; 97-113; PMCID PMC4006985; 10.1007/978-1-61779-334-9_6
• Kedrowski, Sean M. A. and Dougherty, Dennis A. (2010) Room-Temperature Alternative to the Arbuzov Reaction: The Reductive Deoxygenation of Acyl Phosphonates; Organic Letters; Vol. 12; No. 18; 3990-3993; PMCID PMC2941390; 10.1021/ol1015493
• Duffy, Noah H. and Dougherty, Dennis A. (2010) Preparation of Translationally Competent tRNA by Direct Chemical Acylation; Organic Letters; Vol. 12; No. 17; 3776-3779; PMCID PMC2929286; 10.1021/ol101408f
• Blum, Angela P. and Lester, Henry A., et el. (2010) Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH; Proceedings of the National Academy of Sciences of the United States of America; Vol. 107; No. 30; 13206-13211; PMCID PMC2922130; 10.1073/pnas.1007140107
• Hanek, Ariele P. and Lester, Henry A., et el. (2010) Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain Prevents GABA but Not Pentobarbital Activation; Molecular Pharmacology; Vol. 78; No. 1; 29-35; PMCID PMC2912059; 10.1124/mol.109.059832
• Tao, Xiao and Lee, Alice, et el. (2010) A Gating Charge Transfer Center in Voltage Sensors; Science; Vol. 328; No. 5974; 67-73; PMCID PMC2869078; 10.1126/science.1185954
• Limapichat, Walrati and Lester, Henry A., et el. (2010) Chemical Scale Studies of the Phe-Pro Conserved Motif in the Cys Loop of Cys; Journal of Biological Chemistry; Vol. 285; No. 12; 8976-8984; PMCID PMC2838319; 10.1074/jbc.M109.060939
• Eastwood, Amy L. and Blum, Angela P., et el. (2009) A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters; Journal of Organic Chemistry; Vol. 74; No. 23; 9241-9244; PMCID PMC2953381; 10.1021/jo901368g
• Ahern, Christopher A. and Eastwood, Amy L., et el. (2009) An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels; Journal of General Physiology; Vol. 134; No. 6; 461-469; PMCID PMC2806421; 10.1085/jgp.200910260
• Torrice, Michael M. and Bower, Kiowa S., et el. (2009) Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 29; 11919-11924; PMCID PMC2715518; 10.1073/pnas.0903260106
• Gleitsman, Kristin R. and Lester, Henry A., et el. (2009) Probing the role of backbone hydrogen bonding in a critical β sheet of the extracellular domain of a cys-loop receptor; ChemBioChem; Vol. 10; No. 8; 1385-1391; PMCID PMC2789490; 10.1002/cbic.200900092
• Gleitsman, Kristin R. and Shanata, Jai A. P., et el. (2009) Long-Range Coupling in an Allosteric Receptor Revealed by Mutant Cycle Analysis; Biophysical Journal; Vol. 96; No. 8; 3168-3178; PMCID PMC2718292; 10.1016/j.bpj.2008.12.3949
• Xiu, Xinan and Puskar, Nyssa L., et el. (2009) Nicotine binding to brain receptors requires a strong cation–π interaction; Nature; Vol. 458; No. 7237; 534-537; PMCID PMC2755585; 10.1038/nature07768
• Lester, Henry A. and Xiao, Cheng, et el. (2009) Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery; AAPS Journal; Vol. 11; No. 1; 167-177; PMCID PMC2664890; 10.1208/s12248-009-9090-7
• Pantoja, Rigo and Rodriguez, Erik A., et el. (2009) Single-Molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated Into Nicotinic Receptors; Biophysical Journal; Vol. 96; No. 1; 226-237; PMCID PMC2710013; 10.1016/j.bpj.2008.09.034
• Dougherty, D. A. (2009) In Vivo Studies of Receptors and Ion Channels with Unnatural Amino Acids; ISBN 978-3-540-70937-4; Protein Engineering; 231-254; 10.1007/978-3-540-70941-1_8
• Gleitsman, Kristin Rule and Kedrowski, Sean M. A., et el. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating; Journal of Biological Chemistry; Vol. 283; No. 51; 35638-35643; PMCID PMC2602911; 10.1074/jbc.M807226200
• Pless, Stephan A. and Millen, Kat S., et el. (2008) A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue; Journal of Neuroscience; Vol. 28; No. 43; 10937-10942; PMCID PMC2649377; 10.1523/JNEUROSCI.2540-08.2008
• Hanek, Ariele P. and Lester, Henry A., et el. (2008) A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 130; No. 40; 13216-13218; 10.1021/ja8015457
• Price, Kerry L. and Bower, Kiowa S., et el. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT_3 Receptor; Biochemistry; Vol. 47; No. 24; 6370-6377; PMCID PMC264937; 10.1021/bi800222n
• Maurer, Joshua A. and Elmore, Donald E., et el. (2008) Confirming the Revised C-Terminal Domain of the MscL Crystal Structure; Biophysical Journal; Vol. 94; No. 12; 4662-4667; PMCID PMC2397327; 10.1529/biophysj.107.127365
• Dougherty, Dennis A. (2008) Physical Organic Chemistry on the Brain; Journal of Organic Chemistry; Vol. 73; No. 10; 3667-3673; 10.1021/jo8001722
• Dougherty, Dennis A. (2008) Cys-Loop Neuroreceptors: Structure to the Rescue?; Chemical Reviews; Vol. 108; No. 5; 1642-1653; 10.1021/cr078207z
• Bower, Kiowa S. and Price, Kerry L., et el. (2008) 5-Fluorotryptamine is a partial agonist at 5-HT₃ receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function; European Journal of Pharmacology; Vol. 580; No. 3; 291-297; PMCID PMC2649378; 10.1016/j.ejphar.2007.11.014
• Ahern, Christopher A. and Eastwood, Amy L., et el. (2008) Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels; Circulation Research; Vol. 102; No. 1; 86-94; 10.1161/CIRCRESAHA.107.160663
• Ahern, Christopher A. and Eastwood, Amy L., et el. (2008) New insights into the therapeutic inhibition of voltage-gated sodium channels; Channels; Vol. 2; No. 1; 1-3; 10.4161/chan.2.1.6007
• Santarelli, Vincent P. and Eastwood, Amy L., et el. (2007) Calcium Block of Single Sodium Channels: Role of a Pore-Lining Aromatic Residue; Biophysical Journal; Vol. 93; No. 7; 2341-2349; PMCID PMC1965434; 10.1529/biophysj.107.106856
• Rodriguez, Erik A. and Lester, Henry A., et el. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: Minimizing misacylation; RNA; Vol. 13; No. 10; 1703-1714; PMCID PMC1986802; 10.1261/rna.666807
• Rodriguez, Erik A. and Lester, Henry A., et el. (2007) Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 2: Evaluating suppression efficiency; RNA; Vol. 13; No. 10; 1715-1722; PMCID PMC1986817; 10.1261/rna.667607
• Wang, Jinti and Lester, Henry A., et el. (2007) Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway; Journal of Biological Chemistry; Vol. 282; No. 36; 26210-26216; 10.1074/jbc.M702314200
• Kedrowski, Sean M. A. and Bower, Kiowa S., et el. (2007) 1-Oxo-5-hydroxytryptamine: A Surprisingly Potent Agonist of the 5-HT_3(Serotonin) Receptor; Organic Letters; Vol. 9; No. 17; 3205-3207; 10.1021/ol071083s
• Dougherty, Dennis A. (2007) Cation-π Interactions Involving Aromatic Amino Acids; Journal of Nutrition; Vol. 137; No. 6; 1504S-1508S; 10.1093/jn/137.6.1504s
• Maurer, Joshua A. and White, Victor E., et el. (2007) Reconstitution of ion channels in agarose-supported silicon orifices; Biosensors and Bioelectronics; Vol. 22; No. 11; 2577-2584; 10.1016/j.bios.2006.10.017
• Santarelli, Vincent P. and Eastwood, Amy L., et el. (2007) A Cation-π Interaction Discriminates among Sodium Channels That Are Either Sensitive or Resistant to Tetrodotoxin Block; Journal of Biological Chemistry; Vol. 282; No. 11; 8044-8051; 10.1074/jbc.M611334200
• Padgett, Claire L. and Hanek, Ariele P., et el. (2007) Unnatural Amino Acid Mutagenesis of the GABA_A Receptor Binding Site Residues Reveals a Novel Cation-π Interaction between GABA and β₂Tyr97; Journal of Neuroscience; Vol. 27; No. 4; 886-892; PMCID PMC2649369; 10.1523/jneurosci.4791-06.2007
• Cashin, Amanda L. and Torrice, Michael M., et el. (2007) Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor; Biochemistry; Vol. 46; No. 3; 630-639; PMCID PMC3164877; 10.1021/bi061638b
• Ahern, Christopher A. and Eastwood, Amy L., et el. (2006) A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels; Journal of General Physiology; Vol. 128; No. 6; 649-657; PMCID PMC2151593; 10.1085/jgp.200609654
• Rodriguez, Erik A. and Lester, Henry A., et el. (2006) In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 23; 8650-8655; PMCID PMC1482635; 10.1073/pnas.0510817103
• Spronk, Steven A. and Elmore, Donald E., et el. (2006) Voltage-Dependent Hydration and Conduction Properties of the Hydrophobic Pore of the Mechanosensitive Channel of Small Conductance; Biophysical Journal; Vol. 90; No. 10; 3555-3569; PMCID PMC1440736; 10.1529/biophysj.105.080432
• McMenimen, Kathryn A. and Petersson, E. James, et el. (2006) Probing the Mg^(2+) Blockade Site of an N-Methyl-d-aspartate (NMDA) Receptor with Unnatural Amino Acid Mutagenesis; ACS Chemical Biology; Vol. 1; No. 4; 227-234; 10.1021/cb6000944
• Xiu, Xinan and Hanek, Ariele P., et el. (2005) A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors; Journal of Biological Chemistry; Vol. 280; No. 50; 41655-41666; 10.1074/jbc.M508635200
• Lummis, Sarah C. R. and Beene, Darren L., et el. (2005) Cis–trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel; Nature; Vol. 438; No. 4065; 248-252; 10.1038/nature04130
• Lummis, Sarah C. R. and Beene, Darren L., et el. (2005) A Cation-π Binding Interaction with a Tyrosine in the Binding Site of the GABA_C Receptor; Chemistry and Biology; Vol. 12; No. 9; 993-997; 10.1016/j.chembiol.2005.06.012
• Rothman, Deborah M. and Petersson, E. James, et el. (2005) Caged Phosphoproteins; Journal of the American Chemical Society; Vol. 127; No. 3; 846-847; 10.1021/ja043875c
• Cashin, Amanda L. and Petersson, E. James, et el. (2005) Using Physical Chemistry To Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor; Journal of the American Chemical Society; Vol. 127; No. 1; 350-356; 10.1021/ja0461771
• Beene, Darren L. and Price, Kerry L., et el. (2004) Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine₃ Receptor Revealed by Unnatural Amino Acid Mutagenesis; Journal of Neuroscience; Vol. 24; No. 41; 9097-9104; PMCID PMC6730062; 10.1523/jneurosci.2429-04.2004
• Dahan, David S. and Dibas, Mohammed I., et el. (2004) A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 27; 10195-10200; PMCID PMC454187; 10.1073/pnas.0301885101
• Lester, Henry A. and Dibas, Mohammed I., et el. (2004) Cys-loop receptors: new twists and turns; Trends in Neurosciences; Vol. 27; No. 6; 329-336; 10.1016/j.tins.2004.04.002
• Clayton, Daniel and Shapovalov, George, et el. (2004) Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 14; 4764-4769; PMCID PMC387322; 10.1073/pnas.0305693101
• Leite, John F. and Blanton, Michael P., et el. (2003) Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry; Proceedings of the National Academy of Sciences of the United States of America; Vol. 100; No. 22; 13054-13059; PMCID PMC240743; 10.1073/pnas.2133028100
• Elmore, Donald E. and Dougherty, Dennis A. (2003) Investigating Lipid Composition Effects on the Mechanosensitive Channel of Large Conductance (MscL) Using Molecular Dynamics Simulations; Biophysical Journal; Vol. 85; No. 3; 1512-1524; PMCID PMC1303328; 10.1016/s0006-3495(03)74584-6
• Leite, John F. and Dougherty, Dennis A., et el. (2003) Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide; Rapid Communications in Mass Spectrometry; Vol. 17; No. 15; 1677-1684; 10.1002/rcm.1103
• Mu, Ting-Wei and Lester, Henry A., et el. (2003) Different Binding Orientations for the Same Agonist at Homologous Receptors: A Lock and Key or a Simple Wedge?; Journal of the American Chemical Society; Vol. 125; No. 23; 6850-6851; 10.1021/ja0348086
• Maurer, Joshua A. and Dougherty, Dennis A. (2003) Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL - Implications for channel gating and evolutionary design; Journal of Biological Chemistry; Vol. 278; No. 23; 21076-21082; 10.1074/jbc.M302892200
• Beene, Darren L. and Dougherty, Dennis A., et el. (2003) Unnatural amino acid mutagenesis in mapping ion channel function; Current Opinion in Neurobiology; Vol. 13; No. 3; 264-270; 10.1016/s0959-4388(03)00068-0
• Monahan, Sarah L. and Lester, Henry A., et el. (2003) Site-Specific Incorporation of Unnatural Amino Acids into Receptors Expressed in Mammalian Cells; Chemistry and Biology; Vol. 10; No. 6; 573-580; 10.1016/s1074-5521(03)00124-8
• Petersson, E. James and Brandt, Gabriel S., et el. (2003) Caging proteins through unnatural amino acids mutagenesis; ISBN 9780121822637; Biophotonics, Part A; 258-273; 10.1016/s0076-6879(03)60114-x
• Petersson, E. James and Choi, Anita, et el. (2002) A Perturbed pK_a at the Binding Site of the Nicotinic Acetylcholine Receptor: Implications for Nicotine Binding; Journal of the American Chemical Society; Vol. 124; No. 43; 12662-12663; 10.1021/ja028206i
• Beene, Darren L. and Brandt, Gabriel S., et el. (2002) Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT_(3A)) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine; Biochemistry; Vol. 41; No. 32; 10262-10269; 10.1021/bi020266d
• Zacharias, Niki and Dougherty, Dennis A. (2002) Cation–π interactions in ligand recognition and catalysis; Trends in Pharmacological Sciences; Vol. 23; No. 6; 281-287; 10.1016/s0165-6147(02)02027-8
• Petersson, E. J. and Shahgholi, M., et el. (2002) MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production; RNA; Vol. 8; No. 4; 542-547; PMCID PMC1370275
• Dougherty, Dennis A. (2002) The cation-π interaction: From structural biology to neuroreceptor binding sites; ISBN 978-0-7923-6445-0; Peptides for the New Millennium; 550-552; 10.1007/0-306-46881-6_218
• Maurer, Joshua A. and Dougherty, Dennis A. (2001) A high-throughput screen for MscL channel activity and mutational phenotyping; Biochimica et Biophysica Acta - Biomembranes; Vol. 1514; No. 2; 165-169; 10.1016/s0005-2736(01)00390-x
• Elmore, Donald E. and Dougherty, Dennis A. (2001) Molecular Dynamics Simulations of Wild-Type and Mutant Forms of the Mycobacterium tuberculosis MscL Channel; Biophysical Journal; Vol. 81; No. 3; 1345-1359; PMCID PMC1301615; 10.1016/s0006-3495(01)75791-8
• Philipson, Kenneth D. and Gallivan, Justin P., et el. (2001) Incorporation of caged cysteine and caged tyrosine into a transmembrane segment of the nicotinic ACh receptor; American Journal of Physiology. Cell Physiology; Vol. 281; No. 1; C195-C206; 10.1152/ajpcell.2001.281.1.c195
• Dougherty, Dennis A. and Lester, Henry A. (2001) Neurobiology: Snails, synapses and smokers; Nature; Vol. 411; No. 6835; 252-254; 10.1038/35077192
• Tong, Yanhe and Brandt, Gabriel S., et el. (2001) Tyrosine decaging leads to substantial membrane trafficking during modulation of an inward rectifier potassium channel; Journal of General Physiology; Vol. 117; No. 2; 103-118; PMCID PMC2217249; 10.1085/jgp.117.2.103
• Li, Lintong and Zhong, Wenge, et el. (2001) The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor; Chemistry and Biology; Vol. 8; No. 1; 47-58; 10.1016/s1074-5521(00)00055-7
• Dougherty, D. A. (2001) Polymer stereochemistry: an opportunity and a challenge on Titan; Enantiomer; Vol. 6; No. 2-3; 101-106
• Dougherty, Dennis A. (2000) Unnatural amino acids as probes of protein structure and function; Current Opinion in Chemical Biology; Vol. 4; No. 6; 645-652; 10.1016/s1367-5931(00)00148-4
• Maurer, Joshua A. and Elmore, Donald E., et el. (2000) Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL) - New gain of function mutations in the loop region; Journal of Biological Chemistry; Vol. 275; No. 29; 22238-22244; 10.1074/jbc.M003056200
• Dang, Hong and England, Pamela M., et el. (2000) Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine₃ Receptor Gating; Molecular Pharmacology; Vol. 57; No. 6; 1114-1122
• Elmore, Donald E. and Dougherty, Dennis A. (2000) A Computational Study of Nicotine Conformations in the Gas Phase and in Water; Journal of Organic Chemistry; Vol. 65; No. 3; 742-747; 10.1021/jo991383q
• Gallivan, Justin P. and Dougherty, Dennis A. (2000) A Computational Study of Cation−π Interactions vs Salt Bridges in Aqueous Media: Implications for Protein Engineering; Journal of the American Chemical Society; Vol. 122; No. 5; 870-874; 10.1021/ja991755c
• England, Pamela M. and Lester, Henry A., et el. (1999) Mapping Disulfide Connectivity Using Backbone Ester Hydrolysis; Biochemistry; Vol. 38; No. 43; 14409-14415; 10.1021/bi991424c
• Gallivan, Justin P. and Dougherty, Dennis A. (1999) Cation-π interactions in structural biology; Proceedings of the National Academy of Sciences of the United States of America; Vol. 96; No. 17; 9459-9464; PMCID PMC22230; 10.1073/pnas.96.17.9459
• Gallivan, Justin P. and Dougherty, Dennis A. (1999) Can Lone Pairs Bind to a π System? The Water···Hexafluorobenzene Interaction; Organic Letters; Vol. 1; No. 1; 103-106; 10.1021/ol990577p
• Ngola, Sarah M. and Kearney, Patrick C., et el. (1999) A Selective Receptor for Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt Bridges That Are Highly Exposed to Water; Journal of the American Chemical Society; Vol. 121; No. 6; 1192-1201; 10.1021/ja982499r
• England, Pamela M. and Zhang, Yinong, et el. (1999) Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel: Implications for the Mechanism of Gating; Cell; Vol. 96; No. 1; 89-98; 10.1016/s0092-8674(00)80962-9
• Zhong, Wenge and Gallivan, Justin P., et el. (1998) From ab initio quantum mechanics to molecular neurobiology: A cation-pi binding site in the nicotinic receptor; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 21; 12088-12093; PMCID PMC22789; 10.1073/pnas.95.21.12088
• Dougherty, Dennis A. and Lester, Henry A. (1998) The Crystal Structure of a Potassium Channel — A New Era in the Chemistry of Biological Signaling; Angewandte Chemie International Edition; Vol. 37; No. 17; 2329-2331; 10.1002/(SICI)1521-3773(19980918)37:17<2329::AID-ANIE2329>3.0.CO;2-M
• Silverman, Scott K. and Lester, Henry A., et el. (1998) Asymmetrical Contributions of Subunit Pore Regions to Ion Selectivity in an Inward Rectifier K⁺ Channel; Biophysical Journal; Vol. 75; No. 3; 1330-1339; PMCID PMC1299807; 10.1016/s0006-3495(98)74051-2
• Miller, Jeffrey C. and Silverman, Scott K., et el. (1998) Flash Decaging of Tyrosine Sidechains in an Ion Channel; Neuron; Vol. 20; No. 4; 619-624; 10.1016/s0896-6273(00)81001-6
• Lester, Henry A. and Dougherty, Dennis A. (1998) New Views of Multi-Ion Channels; Journal of General Physiology; Vol. 111; No. 2; 181-183; PMCID PMC2222761; 10.1085/jgp.111.2.181
• Dougherty, Dennis A. (1998) Stereochemical issues in studies of ion channel proteins; Chirality; Vol. 10; No. 1-2; 8-13; 10.1002/chir.3
• Nowak, Mark W. and Gallivan, Justin P., et el. (1998) In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system; ISBN 978-0-12-182194-4; Ion Channels Part B; 504-529; 10.1016/s0076-6879(98)93031-2
• West, Anthony P., Jr. and Bjorkman, Pamela J., et el. (1997) Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor; Journal of Biological Chemistry; Vol. 272; No. 41; 25468-25473; 10.1074/jbc.272.41.25468
• Gallivan, Justin P. and Lester, Henry A., et el. (1997) Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins; Chemistry and Biology; Vol. 4; No. 10; 739-749; 10.1016/s1074-5521(97)90312-4
• England, Pamela M. and Lester, Henry A., et el. (1997) Site-specific, photochemical proteolysis applied to ion channels in vivo; Proceedings of the National Academy of Sciences of the United States of America; Vol. 94; No. 20; 11025-11030; PMCID PMC23572; 10.1073/pnas.94.20.11025
• Dougherty, Dennis A. (1997) Physical organic chemistry in the brain; Pure and Applied Chemistry; Vol. 69; No. 9; 1969-1978; 10.1351/pac199769091969
• Ma, Jennifer C. and Dougherty, Dennis A. (1997) The Cation−π Interaction; Chemical Reviews; Vol. 97; No. 5; 1303-1324; 10.1021/cr9603744
• Silverman, Scott K. and Kofuji, Paulo, et el. (1996) A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 26; 15429-15434; PMCID PMC26421; 10.1073/pnas.93.26.15429
• Kearney, Patrick C. and Zhang, Haiyun, et el. (1996) Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9′ Position; Neuron; Vol. 17; No. 6; 1221-1229; 10.1016/s0896-6273(00)80252-4
• Silverman, Scott K. and Lester, Henry A., et el. (1996) Subunit Stoichiometry of a Heteromultimeric G protein-coupled Inward-rectifier K^+ Channel; Journal of Biological Chemistry; Vol. 271; No. 48; 30524-30528; 10.1074/jbc.271.48.30524
• Kearney, Patrick C. and Nowak, Mark W., et el. (1996) Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists; Molecular Pharmacology; Vol. 50; No. 5; 1401-1412
• Mecozzi, Sandro and West, Anthony P., Jr., et el. (1996) Cation-pi interactions in aromatics of biological and medicinal interest: Electrostatic potential surfaces as a useful qualitative guide; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 20; 10566-10571; PMCID PMC38193
• Saks, Margaret E. and Sampson, Jeffrey R., et el. (1996) An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression; Journal of Biological Chemistry; Vol. 271; No. 38; 23169-23175
• Dougherty, Dennis A. (1996) Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp; Science; Vol. 271; No. 5246; 163-168; 10.1126/science.271.5246.163
• Ngola, Sarah M. and Dougherty, Dennis A. (1996) Evidence for the Importance of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors; Journal of Organic Chemistry; Vol. 61; No. 13; 4355-4360; 10.1021/jo960521y
• Nowak, Mark W. and Kearney, Patrick C., et el. (1995) Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells; Science; Vol. 268; No. 5209; 439-442; 10.1126/science.7716551
• Silverman, Scott K. and Dougherty, Dennis A. (1993) Conformational effects on high-spin organic molecules; Journal of Physical Chemistry; Vol. 97; No. 50; 13273-13283; 10.1021/j100152a035
• Kearney, Patrick C. and Mizoue, Laura S., et el. (1993) Molecular recognition in aqueous media. New binding studies provide further insights into the cation-π interaction and related phenomena; Journal of the American Chemical Society; Vol. 115; No. 22; 9907-9919; 10.1021/ja00075a006
• Forman, J. E. and Marsh, R. E., et el. (1993) Structure of a Cyclophane Host Molecule; Acta crystallographica. Section B, Structural science; Vol. 49; No. 5; 892-896; 10.1107/S0108768193002435
• Kumpf, Robert A. and Dougherty, Dennis A. (1993) A mechanism for ion selectivity in potassium channels: computational studies of cation-π interactions; Science; Vol. 261; No. 5129; 1708-1710; 10.1126/science.8378771
• Jacobs, S. Joshua and Shultz, David A., et el. (1993) Evaluation of potential ferromagnetic coupling units: the bis(TMM) [bis(trimethylenemethane)] approach to high-spin organic molecules; Journal of the American Chemical Society; Vol. 115; No. 5; 1744-1753; 10.1021/ja00058a020
• McCurdy, Alison and Jimenez, Leslie, et el. (1992) Biomimetic catalysis of S_N2 reactions through cation-π interactions. The role of polarizability in catalysis; Journal of the American Chemical Society; Vol. 114; No. 26; 10314-10321; 10.1021/ja00052a031
• Dougherty, Dennis A. (1991) Spin control in organic molecules; Accounts of Chemical Research; Vol. 24; No. 3; 88-94; 10.1021/ar00003a005
• Dougherty, Dennis A. and Stauffer, David A. (1990) Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition; Science; Vol. 250; No. 4987; 1558-1560; 10.1126/science.2274786
• Stauffer, David A. and Barrans, Richard E., Jr., et el. (1990) Concerning the thermodynamics of molecular recognition in aqueous and organic media. Evidence for significant heat capacity effects; Journal of Organic Chemistry; Vol. 55; No. 9; 2762-2767; 10.1021/jo00296a038
• Dougherty, Dennis A. (1990) New high-spin π systems; Pure and Applied Chemistry; Vol. 62; No. 3; 519-524; 10.1351/pac199062030519
• Shepodd, Timothy J. and Petti, Michael A., et el. (1986) Tight, oriented binding of an aliphatic guest by a new class of water-soluble molecules with hydrophobic binding sites; Journal of the American Chemical Society; Vol. 108; No. 19; 6085-6087; 10.1021/ja00279a093
• Dougherty, Dennis A. and Choi, Chang Sun, et el. (1986) Effects of Substituents on the Length of Central C(sp^3)-C(sp^3) Bond in Anthracene Photodimers and Related Molecules; Journal of the Chemical Society-Perkin Transactions 2; No. 7; 1063-1070; 10.1039/P29860001063
• Dervan, Peter B. and Dougherty, Dennis A. (1982) Nonconjugated Diradicals; ISBN 0471086614; Diradicals; 107-149
• Lokensgard, David M. and Dougherty, Dennis A., et el. (1980) Mechanism of thermal rearrangement of the spiro bicyclo[2.1.0]-pentane-5,2'-methylenecyclopropanes to 6- and 7- methylenebicyclo[3.2.0]hept-1-enes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 77; No. 6; 3090-3094; PMCID PMC349557; 10.1073/pnas.77.6.3090
• Winstead, Meldrum B. and Dougherty, Dennis A., et el. (1978) Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters; Journal of Medicinal Chemistry; Vol. 21; No. 2; 215-217; 10.1021/jm00200a014