Hsieh-Wilson, Linda
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- Griffin, Matthew E. and Hsieh-Wilson, Linda C. (2022) Tools for mammalian glycoscience research; Cell; Vol. 185; No. 15; 2657-2677; PMCID PMC9339253; 10.1016/j.cell.2022.06.016
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- Hsieh-Wilson, Linda (2021) Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and synaptic plasticity; Glycobiology; Vol. 31; No. 12; 1690; 10.1093/glycob/cwab121
- Hsieh-Wilson, Linda C. (2021) Synthesis of heparan sulfate glycosaminoglycan (HS GAG) libraries for unlocking the sulfation code and understanding GAG biology
- Griffin, Matthew E. and Sorum, Alexander W., et el. (2021) Sulfated glycans engage the Ang–Tie pathway to regulate vascular development; Nature Chemical Biology; Vol. 17; No. 2; 178-186; PMCID PMC8087285; 10.1038/s41589-020-00657-7
- Joffrin, Amélie M. and Hsieh-Wilson, Linda C. (2020) Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins; Journal of the American Chemical Society; Vol. 142; No. 32; 13672-13676; PMCID PMC7641097; 10.1021/jacs.0c06046
- Hsieh-Wilson, Linda C. (2020) Streamlined synthesis of heparan sulfate glycosaminoglycans and their roles in regulating vasculature development and homeostasis
- Pawar, Nitin J. and Wang, Lei, et el. (2019) Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly; Angewandte Chemie International Edition; Vol. 58; No. 51; 18577-18583; PMCID PMC6901730; 10.1002/anie.201908805
- Liu, Liang‐Chih and Wang, Yuan‐Liang, et el. (2019) Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15; International Journal of Cancer; Vol. 145; No. 9; 2478-2487; 10.1002/ijc.32319
- Liu, Liang-Chih and Wang, Yuan-Liang, et el. (2019) Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15; International Journal of Cancer; Vol. 145; No. 9; 2478-2487; 10.1002/ijc.32319
- Hsieh-Wilson, Linda C. (2019) Chemical approaches toward a quantitative, systems-level understanding of protein O-GlcNAcylation signaling networks
- Pawar, Nitin Jalindar and Wang, Lei, et el. (2019) Streamlined synthesis of core disaccharide building blocks from natural polysaccharides for the generation of heparan sulfate libraries
- Li, Xuexia and Zhu, Qiang, et el. (2019) O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 16; 7857-7866; PMCID PMC6475381; 10.1073/pnas.1813026116
- Hsieh-Wilson, Linda C. (2019) Streamlined methods for the synthesis of heparan sulfate oligosaccharide libraries
- Li, Jingchao and Li, Zhonghua, et el. (2019) An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation; ACS Chemical Biology; Vol. 14; No. 1; 4-10; 10.1021/acschembio.8b01052
- Darabedian, Narek and Thompson, John W., et el. (2018) Optimization of chemoenzymatic mass-tagging by strain-promoted cycloaddition (SPAAC) for the determination of O-GlcNAc stoichiometry by Western blotting; Biochemistry; Vol. 57; No. 40; 5769-5774; PMCID PMC6211186; 10.1021/acs.biochem.8b00648
- Stopschinski, Barbara E. and Holmes, Brandon B., et el. (2018) Specific Glycosaminoglycan Chain Length and Sulfation Patterns Are Required for Cell Uptake of Tau vs. α-Synuclein and β-Amyloid Aggregates; Annals of Neurology; Vol. 84; No. S22; S67-S68; 10.1002/ana.25331
- Thompson, John W. and Sorum, Alexander W., et el. (2018) Deciphering the functions of O-GlcNAc glycosylation in the brain: The role of site-specific quantitative O-GlcNAcomics; Biochemistry; Vol. 57; No. 27; 4010-4018; PMCID PMC6058732; 10.1021/acs.biochem.8b00516
- Hsieh-Wilson, Linda C. (2018) A Molecular Window into the Brain: Special Issue on Molecules and the Brain; Biochemistry; Vol. 57; No. 27; 3989-3990; 10.1021/acs.biochem.8b00689
- Stopschinski, Barbara E. and Holmes, Brandon B., et el. (2018) Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates; Journal of Biological Chemistry; Vol. 293; No. 27; 10826-10840; PMCID PMC6036193; 10.1074/jbc.RA117.000378
- Rauch, Jennifer N. and Chen, John J., et el. (2018) Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs); Scientific Reports; Vol. 8; Art. No. 6382; PMCID PMC5913225; 10.1038/s41598-018-24904-z
- Hsieh-Wilson, Linda (2018) O-GlcNAc glycosylation: From reductionism to systems biology
- Matho, Michael H. and Schlossman, Andrew, et el. (2018) Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8; Journal of Biological Chemistry; Vol. 293; No. 1; 390-401; PMCID PMC5766908; 10.1074/jbc.M117.814541
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- Griffith, Adam R. and Rogers, Claude J., et el. (2017) Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth; Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 52; 13697-13702; PMCID PMC5748211; 10.1073/pnas.1715093115
- Cheung, Sheldon T. and Miller, Michelle S., et el. (2017) Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation; ACS Chemical Biology; Vol. 12; No. 12; 3126-3133; PMCID PMC5896753; 10.1021/acschembio.7b00885
- Wang, Andrew C. and Jensen, Elizabeth H., et el. (2016) Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration; Proceedings of the National Academy of Sciences of the United States of America; Vol. 113; No. 52; 15120-15125; PMCID PMC5206508; 10.1073/pnas.1606899113
- Hsieh-Wilson, Linda C. (2016) Synthetic probes for understanding glycosaminoglycan recognition and signaling in the brain
- Griffin, Matthew E. and Jensen, Elizabeth H., et el. (2016) Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag; Molecular BioSystems; Vol. 12; No. 6; 1756-1759; PMCID PMC4905554; 10.1039/C6MB00138F
- Griffin, Matthew E. and Hsieh-Wilson, Linda C. (2016) Glycan Engineering for Cell and Developmental Biology; Cell Chemical Biology; Vol. 23; No. 1; 108-121; PMCID PMC4857608; 10.1016/j.chembiol.2015.12.007
- Miller, Gregory M. and Hsieh-Wilson, Linda C. (2015) Sugar-Dependent Modulation of Neuronal Development, Regeneration, and Plasticity by Chondroitin Sulfate Proteoglycans; Experimental Neurology; Vol. 274; No. B; 115-125; PMCID PMC4679498; 10.1016/j.expneurol.2015.08.015
- Hsieh-Wilson, Linda C. (2015) Carbohydrate signaling in the brain; Abstracts of Papers of the American Chemical Society; Vol. 249; CELL-191
- Pulsipher, Abigail and Griffin, Matthew E., et el. (2015) Long-Lived Engineering of Glycans to Direct Stem Cell Fate; Angewandte Chemie International Edition; Vol. 54; No. 5; 1466-1470; PMCID PMC4533927; 10.1002/anie.201409258
- Matho, Michael H. and de Val, Natalia, et el. (2014) Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E; PLoS Pathogens; Vol. 10; No. 12; Art. No. e1004495; PMCID PMC4256255; 10.1371/journal.ppat.1004495
- Wibowo, Arif and Peters, Eric C., et el. (2014) Photoactivatable Glycopolymers for the Proteome-Wide Identification of Fucose-α(1-2)-Galactose Binding Proteins; Journal of the American Chemical Society; Vol. 136; No. 27; 9528-9531; PMCID PMC4105059; 10.1021/ja502482a
- Pulsipher, Abigail and Griffin, Matthew E., et el. (2014) Directing Neuronal Signaling through Cell-Surface Glycan Engineering; Journal of the American Chemical Society; Vol. 136; No. 19; 6794-6797; PMCID PMC4120997; 10.1021/ja5005174
- Hsieh-Wilson, Linda C. (2014) Carbohydrate signaling in the brain
- Hsieh-Wilson, Linda C. (2014) Harnessing chemistry to discover new roles for carbohydrates in neurobiology and cancer
- Hsieh-Wilson, Linda C. and Griffin, Matthew E. (2013) Improving Biologic Drugs via Total Chemical Synthesis; Science; Vol. 342; No. 6164; 1332-1333; 10.1126/science.1247615
- Griffin, Matthew E. and Hsieh-Wilson, Linda C. (2013) Synthetic probes of glycosaminoglycan function; Current Opinion in Chemical Biology; Vol. 17; No. 6; 1014-1022; PMCID PMC3934325; 10.1016/j.cbpa.2013.09.015
- Clark, Peter M. and Rexach, Jessica E., et el. (2013) Visualization of O-GlcNAc Glycosylation Stoichiometry and Dynamics Using Resolvable Poly(ethylene glycol) Mass Tags; Current Protocols in Chemical Biology; Vol. 5; 281-302; PMCID PMC3931299; 10.1002/9780470559277.ch130153
- Oh, Young In and Sheng, Gloria J., et el. (2013) Tailored Glycopolymers as Anticoagulant Heparin Mimetics; Angewandte Chemie International Edition; Vol. 52; No. 45; 11796-11799; PMCID PMC3943734; 10.1002/anie.201306968
- Dick, Gunnar and Tan, Chin Lik, et el. (2013) Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains; Journal of Biological Chemistry; Vol. 288; No. 38; 27384-27395; PMCID PMC3779733; 10.1074/jbc.M111.310029
- Ramakrishnan, Parameswaran and Clark, Peter M., et el. (2013) Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation; Science Signaling; Vol. 6; No. 290; Art. No. ra75; PMCID PMC4066889; 10.1126/scisignal.2004097
- Sheng, Gloria J. and Oh, Young In, et el. (2013) Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity; Journal of the American Chemical Society; Vol. 135; No. 30; 10898-10901; PMCID PMC3732023; 10.1021/ja4027727
- Chaubard, Jean-Luc and Krishnamurthy, Chithra, et el. (2013) Chemoenzymatic approaches to the imaging and detection of cancer relevant fucosylated glycoconjugates
- Hsieh-Wilson, Linda C. (2013) O-GlcNAc Signaling Regulates Cancer Metabolism; FASEB Journal; Vol. 27; Art. No. 452.2
- Wang, Andrew C. and Yi, Wen, et el. (2013) Investigating the role of O-GlcNAc glycosylation in cancer and neurodegenerative disease
- Yi, Wen and Clark, Peter M., et el. (2012) Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism; Science; Vol. 337; No. 6097; 975-980; PMCID PMC3534962; 10.1126/science.1222278
- Hsieh-Wilson, Linda C. (2012) Sweet chemical signaling: Understanding the structure-function relationships of carbohydrates in neurobiology and cancer
- Brown, Joshua M. and Xia, Jiang, et el. (2012) A sulfated carbohydrate epitope inhibits axon regeneration after injury; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 13; 4768-4773; PMCID PMC3323996; 10.1073/pnas.1121318109
- Chaubard, Jean-Luc and Krishnamurthy, Chithra, et el. (2012) Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers; Journal of the American Chemical Society; Vol. 134; No. 10; 4489-4492; PMCID PMC3303202; 10.1021/ja211312u
- Rexach, Jessica E. and Clark, Peter M., et el. (2012) Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation; Nature Chemical Biology; Vol. 8; No. 3; 253-261; PMCID PMC3288555; 10.1038/NCHEMBIO.770
- Rogers, Claude J. and Hsieh-Wilson, Linda C. (2012) Microarray Method for the Rapid Detection of Glycosaminoglycan–Protein Interactions; ISBN 9781617793721; Carbohydrate Microarrays: Methods and Protocols; 321-336; PMCID PMC4137757; 10.1007/978-1-61779-373-8_22
- Rogers, Claude J. and Clark, Peter M., et el. (2011) Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches; Proceedings of the National Academy of Sciences of the United States of America; Vol. 108; No. 24; 9747-9752; PMCID PMC3116396; 10.1073/pnas.1102962108
- Hsieh-Wilson, L. (2010) Chemical approaches to elucidating the neurobiology of carbohydrates
- Lee, Song-Gil and Brown, Joshua M., et el. (2010) End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans; Chemical Science; Vol. 1; No. 3; 322-325; PMCID PMC3026345; 10.1039/c0sc00271b
- Rexach, Jessica E. and Rogers, Claude J., et el. (2010) Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags; Nature Chemical Biology; Vol. 6; No. 9; 645-651; PMCID PMC2924450; 10.1038/NCHEMBIO.412
- Murrey, Heather E. and Ficarro, Scott B., et el. (2009) Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb; Biochemistry; Vol. 48; No. 30; 7261-7270; PMCID PMC2717711; 10.1021/bi900640x
- Wang, Zihao and Park, Kyoungsook, et el. (2009) Site-Specific GlcNAcylation of Human Erythrocyte Proteins Potential Biomarker(s) for Diabetes; Diabetes; Vol. 58; No. 2; 309-317; PMCID PMC2628603; 10.2337/db08-0994
- Clark, Peter M. and Dweck, Jessica F., et el. (2008) Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins; Journal of the American Chemical Society; Vol. 130; No. 35; 11576-11577; PMCID PMC2649877; 10.1021/ja8030467
- Murrey, Heather E. and Hsieh-Wilson, Linda C. (2008) The Chemical Neurobiology of Carbohydrates; Chemical Reviews; Vol. 108; No. 5; 1708-1731; PMCID PMC4004190; 10.1021/cr078215f
- Rawat, Manish and Gama, Cristal I., et el. (2008) Neuroactive chondroitin sulfate glycomimetics; Journal of the American Chemical Society; Vol. 130; No. 10; 2959-2961; PMCID PMC3034635; 10.1021/ja709993p
- Rexach, Jessica E. and Clark, Peter M., et el. (2008) Chemical approaches to understanding O-GlcNAc glycosylation in the brain; Nature Chemical Biology; Vol. 4; No. 2; 97-106; PMCID PMC3250351; 10.1038/nchembio.68
- Sotogaku, Naoki and Tully, Sarah E., et el. (2007) Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons; Journal of Neurochemistry; Vol. 103; No. 2; 749-760; 10.1111/j.1471-4159.2007.04849.x
- Khidekel, Nelly and Ficarro, Scott B., et el. (2007) Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics; Nature Chemical Biology; Vol. 3; No. 6; 339-348; 10.1038/nchembio881
- Boeggeman, Elizabeth and Ramakrishnan, Boopathy, et el. (2007) Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method; Bioconjugate Chemistry; Vol. 18; No. 3; 806-814; PMCID PMC3534963; 10.1021/bc060341n
- Shipp, Eric L. and Hsieh-Wilson, Linda C. (2007) Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays; Chemistry and Biology; Vol. 14; No. 2; 195-208; 10.1016/j.chembiol.2006.12.009
- Hsieh-Wilson, Linda C. (2007) Bioorganic Chemistry: A Sweet Synthesis; Nature; Vol. 445; No. 7123; 31-33; 10.1038/445031a
- Gama, Cristal I. and Tully, Sarah E., et el. (2006) Sulfation patterns of glycosaminoglycans encode molecular recognition and activity; Nature Chemical Biology; Vol. 2; No. 9; 467-473; 10.1038/nchembio810
- Tully, Sarah E. and Rawat, Manish, et el. (2006) Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays; Journal of the American Chemical Society; Vol. 128; No. 24; 7740-7741; 10.1021/ja061906t
- Murrey, Heather E. and Gama, Cristal I., et el. (2006) Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 1; 21-26; PMCID PMC1324972; 10.1073/pnas.0503381102
- Uematsu, Ken and Futter, Marie, et el. (2005) Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways; Journal of Neurochemistry; Vol. 95; No. 6; 1642-1652; 10.1111/j.1471-4159.2005.03491.x
- Gama, Cristal I. and Hsieh-Wilson, Linda C. (2005) Chemical approaches to deciphering the glycosaminoglycan code; Current Opinion in Chemical Biology; Vol. 9; No. 6; 609-619; 10.1016/j.cbpa.2005.10.003
- Kalovidouris, Stacey A. and Gama, Cristal I., et el. (2005) A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth; Journal of the American Chemical Society; Vol. 127; No. 5; 1340-1341; 10.1021/ja044631v
- Hsieh-Wilson, Linda C. (2004) Tailor-made glycoproteins; Trends in Biotechnology; Vol. 22; No. 10; 489-491; 10.1016/j.tibtech.2004.08.009
- Khidekel, Nelly and Ficarro, Scott B., et el. (2004) Exploring the O-GlcNAc proteome: Direct identification of O-GlcNAc-modified proteins from the brain; Proceedings of the National Academy of Sciences of the United States of America; Vol. 101; No. 36; 13132-13137; PMCID PMC516536; 10.1073/pnas.0403471101
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- Grossman, Stacie D. and Futter, Marie, et el. (2004) Spinophilin is phosphorylated by Ca^(2+)/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin; Journal of Neurochemistry; Vol. 90; No. 2; 317-324; 10.1111/j.1471-4159.2004.02491.x
- Tully, Sarah E. and Mabon, Ross, et el. (2004) A chondroitin sulfate small molecule that stimulates neuronal growth; Journal of the American Chemical Society; Vol. 126; No. 25; 7736-7737; 10.1021/ja0484045
- Khidekel, Nelly and Hsieh-Wilson, Linda C. (2004) A 'molecular switchboard' - covalent modifications to proteins and their impact on transcription; Organic and Biomolecular Chemistry; Vol. 2; No. 1; 1-7; 10.1039/b312466e
- Khidekel, Nelly and Arndt, Sabine, et el. (2003) A Chemoenzymatic Approach toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications; Journal of the American Chemical Society; Vol. 125; No. 52; 16162-16163; 10.1021/ja038545r
- Arndt, Sabine and Hsieh-Wilson, Linda C. (2003) Use of Cerny epoxides for the accelerated synthesis of glycosaminoglycans; Organic Letters; Vol. 5; No. 22; 4179-4182; 10.1021/ol035606h
- Lamarre-Vincent, Nathan and Hsieh-Wilson, Linda C. (2003) Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation; Journal of the American Chemical Society; Vol. 125; No. 22; 6612-6613; 10.1021/ja028200t
- Hsieh-Wilson, Linda C. and Benfenati, Fabio, et el. (2003) Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments; Journal of Biological Chemistry; Vol. 278; No. 2; 1186-1194; 10.1074/jbc.M205754200
- Grossman, Stacie D. and Hsieh-Wilson, Linda C., et el. (2002) The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines; NeuroMolecular Medicine; Vol. 2; No. 1; 61-69; 10.1385/NMM:2:1:61
- Watanabe, Takuo and Huang, Hsien-Bin, et el. (2001) Protein phosphatase 1 regulation by inhibitors and targeting subunits; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 6; 3080-3085; PMCID PMC30610; 10.1073/pnas.051003898
- Allen, P. B. and Hsieh-Wilson, Linda C., et el. (1999) Control of protein phosphatase I in the dendrite; Biochemical Society Transactions; Vol. 27; No. 4; 543-546; 10.1042/bst0270543
- Hsieh-Wilson, Linda C. and Allen, Patrick B., et el. (1999) Characterization of the Neuronal Targeting Protein Spinophilin and Its Interactions with Protein Phosphatase-1; Biochemistry; Vol. 38; No. 14; 4365-4373; 10.1021/bi982900m
- Yan, Zhen and Hsieh-Wilson, Linda, et el. (1999) Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP−32 and spinophilin; Nature Neuroscience; Vol. 2; No. 1; 13-17; 10.1038/4516
- Ma, Lifu and Hsieh-Wilson, Linda C., et el. (1998) Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 13; 7251-7256; PMCID PMC22581
- Hsieh-Wilson, Linda C. and Schultz, Peter G., et el. (1996) Insights into antibody catalysis: Structure of an oxygenation catalyst at 1.9-Å resolution; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 11; 5363-5367; PMCID PMC39251
- Hsieh-Wilson, Linda C. and Xiang, Xiao-Dong, et el. (1996) Lessons from the immune system: From catalysis to materials science; Accounts of Chemical Research; Vol. 29; No. 3; 164-170; 10.1021/ar950247e
- Stevens, Raymond C. and Hsieh-Wilson, Linda C., et el. (1996) Structural Studies of Catalytic Antibodies; Israel Journal of Chemistry; Vol. 36; No. 2; 121-132; 10.1002/ijch.199600018
- Hsieh-Wilson, Linda C. and Stephans, James C., et el. (1994) An Efficient Antibody-Catalyzed Oxygenation Reaction; Journal of the American Chemical Society; Vol. 116; No. 5; 2167-2168; 10.1021/ja00084a076
- Yu, Jaehoon and Hsieh-Wilson, Linda C., et el. (1994) Progress toward an Antibody Glycosidase; Angewandte Chemie-International Edition In English; Vol. 33; No. 3; 339-341; 10.1002/anie.199403391
- Hsieh-Wilson, Linda C. and Yonkovich, Shirlee, et el. (1993) Controlling Chemical Reactivity with Antibodies; Science; Vol. 260; No. 5106; 337-339; 10.1126/science.10049109