Patterson, Paul H.

Article from CaltechAUTHORS

• Ko, Jan and Isas, J. Mario, et el. (2018) Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin; Human Molecular Genetics; Vol. 27; No. 13; 2330-2343; PMCID PMC6005051; 10.1093/hmg/ddy141
• Khoshnan, Ali and Sabbaugh, Adam, et el. (2017) IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD; Human Molecular Genetics; Vol. 26; No. 21; 4267-4277; PMCID PMC5886231; 10.1093/hmg/ddx315
• Wu, Wei-Li and Hsiao, Elaine Y., et el. (2017) The Placental Interleukin-6 Signaling Controls Fetal Brain Development and Behavior; Brain, Behavior, and Immunity; Vol. 62; 11-23; PMCID PMC5373986; 10.1016/j.bbi.2016.11.007
• Choi, Harry M. T. and Calvert, Colby R., et el. (2016) Mapping a multiplexed zoo of mRNA expression; Development; Vol. 143; No. 19; 3632-3637; PMCID PMC5087610; 10.1242/dev.140137
• Weir, Ruth K. and Forghany, Reihaneh, et el. (2015) Preliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation; Brain, Behavior, and Immunity; Vol. 48; 139-146; PMCID PMC5671487; 10.1016/j.bbi.2015.03.009
• Machado, Christopher J. and Whitaker, Alexander M., et el. (2015) Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring; Biological Psychiatry; Vol. 77; No. 9; 823-832; 10.1016/j.biopsych.2014.07.035
• Wu, Wei-Li and Adams, Catherine E., et el. (2015) The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring; Brain, Behavior, and Immunity; Vol. 46; 192-202; PMCID PMC4414803; 10.1016/j.bbi.2015.02.005
• Wu, Wei-Li and Adams, C. E., et el. (2015) Nicotinic Cholinergic Modulation of the Fetal Brain Response to Maternal Immune Activation; Schizophrenia Bulletin; Vol. 41; No. S1; S216
• Wu, Wei-Li and Hsiao, Elaine Y., et el. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation; Schizophrenia Bulletin; Vol. 41; No. S1; Art. No. S216
• Coban, Hasan B. and Demirci, Ali, et el. (2014) Screening of phenylpyruvic acid producers and optimization of culture conditions in bench scale bioreactors; Bioprocess and Biosystems Engineering; Vol. 37; No. 11; 2343-2352; 10.1007/s00449-014-1212-7
• Malkova, Natalia V. and Gallagher, Joseph J., et el. (2014) Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 24; E2492-E2500; PMCID PMC4066472; 10.1073/pnas.1323287111
• Deverman, Benjamin E. and Simpson, Bryan, et el. (2014) Engineering Recombinant AAV Vectors for More Efficient and Restricted Gene Expression in the CNS after Systemic Administration; Molecular Therapy; Vol. 22; No. S1; S118; 10.1038/mt.2014.66
• Bauman, Melissa D. and Iosif, Ana-Maria, et el. (2014) Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring; Biological Psychiatry; Vol. 75; No. 4; 332-341; 10.1016/j.biopsych.2013.06.025
• Hsiao, Elaine Y. and McBride, Sara W., et el. (2013) Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders; Cell; Vol. 155; No. 7; 1451-1463; PMCID PMC3897394; 10.1016/j.cell.2013.11.024
• Garay, Paula A. and Hsiao, Elaine Y., et el. (2013) Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development; Brain, Behavior, and Immunity; Vol. 31; 54-68; PMCID PMC3529133; 10.1016/j.bbi.2012.07.008
• Fatemi, Hossein S. and Folsom, T. D., et el. (2013) Prenatal human influenza viral infection and brain disorder in mouse: Relevance for genesis of schizophrenia; Neurotoxicology and Teratology; Vol. 37; 76; 10.1016/j.ntt.2013.03.012
• Fatemi, S. H. and Folsom, T. D., et el. (2013) Prenatal Human Influenza Viral Infection and Brain Disorder in Mouse: Relevance for Genesis of Schizophrenia; Birth Defects Research Part A: Clinical and Molecular Teratology; Vol. 97; No. 5; 276-276; 10.1002/bdra.23146
• Hsiao, Elaine Y. and McBride, Sara W., et el. (2012) Neuroimmune changes in a mouse model of the maternal infection risk factor for schizophrenia and autism; Journal of Neuroimmunology; Vol. 253; No. 1-2; 48; 10.1016/j.jneuroim.2012.10.001
• Hsiao, Elaine Y. and McBride, Sara W., et el. (2012) Gastrointestinal symptoms and probiotic treatment in a mouse model of an autism risk factor; Journal of Neuroimmunology; Vol. 253; No. 1-2; 47-48; 10.1016/j.jneuroim.2012.10.001
• Hsiao, E. Y. and Patterson, P. H. (2012) Maternal immune activation induces IL-6-dependent alterations in cytokine and gene expression profiles in the offspring; International Journal of Developmental Neuroscience; Vol. 30; No. 8; 662-663; 10.1016/j.ijdevneu.2012.03.304
• Patterson, Paul H. (2012) Modeling the maternal infection risk factor for schizophrenia and autism in mice; International Journal of Developmental Neuroscience; Vol. 30; No. 8; 628-629; 10.1016/j.ijdevneu.2012.10.072
• McAllister, A. Kimberley and Patterson, Paul H. (2012) Introduction to special issue on neuroimmunology in brain development and disease; Developmental Neurobiology; Vol. 72; No. 10; 1269-1271; PMCID PMC4357356; 10.1002/dneu.22054
• Hsiao, Elaine Y. and Patterson, Paul H. (2012) Placental regulation of maternal-fetal interactions and brain development; Developmental Neurobiology; Vol. 72; No. 10; 1317-1326; 10.1002/dneu.22045
• Bugg, Charles W. and Isas, J. Mario, et el. (2012) Structural Features and Domain Organization of Huntingtin Fibrils; Journal of Biological Chemistry; Vol. 287; No. 38; 31739-31746; PMCID PMC3442508; 10.1074/jbc.M112.353839
• Hsiao, Elaine Y. and McBride, Sara W., et el. (2012) Modeling an autism risk factor in mice leads to permanent immune dysregulation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 31; 12776-12781; PMCID PMC3411999; 10.1073/pnas.1202556109
• Khoshnan, Ali and Patterson, Paul H. (2012) Elevated IKKα Accelerates the Differentiation of Human Neuronal Progenitor Cells and Induces MeCP2-Dependent BDNF Expression; PLoS ONE; Vol. 7; No. 7; e41794; PMCID PMC3407048; 10.1371/journal.pone.0041794
• Malkova, Natalia V. and Yu, Collin Z., et el. (2012) Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism; Brain, Behavior and Immunity; Vol. 26; No. 4; 607-616; PMCID PMC3322300; 10.1016/j.bbi.2012.01.011
• Garbett, K. A. and Hsiao, E. Y., et el. (2012) Effects of maternal immune activation on gene expression patterns in the fetal brain; Translational Psychiatry; Vol. 2; Art. No. e98; PMCID PMC3337077; 10.1038/tp.2012.24
• Patterson, Paul H. (2012) Maternal infection and autism; Brain, Behavior, and Immunity; Vol. 26; No. 3; 393-393; 10.1016/j.bbi.2011.09.008
• Deverman, Benjamin E. and Patterson, Paul H. (2012) Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination; Journal of Neuroscience; Vol. 32; No. 6; 2100-2109; PMCID PMC3561904; 10.1523/JNEUROSCI.3803-11.2012
• Carlisle, Holly J. and Luong, Tinh N., et el. (2011) Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction; Journal of Neuroscience; Vol. 31; No. 45; 16194-16207; PMCID PMC3235477; 10.1523/JNEUROSCI.5877-10.2011
• Khoshnan, Ali and Patterson, Paul H. (2011) The role of IkB kinase complex in the neurobiology of Huntington's disease; Neurobiology of Disease; Vol. 43; No. 2; 305-311; PMCID PMC3124142; 10.1016/j.nbd.2011.04.015
• Patterson, Paul H. (2011) Maternal infection and immune involvement in autism; Trends in Molecular Medicine; Vol. 17; No. 7; 389-394; PMCID PMC3135697; 10.1016/j.molmed.2011.03.001
• Patterson, Paul H. (2011) Modeling Autistic Features in Animals; Pediatric Research; Vol. 69; No. 5; 34R-40R; PMCID PMC3088489; 10.1203/PDR.0b013e318212b80f
• Hsiao, Elaine Y. and Patterson, Paul H. (2011) Activation of the maternal immune system induces endocrine changes in the placenta via IL-6; Brain, Behavior, and Immunity; Vol. 25; No. 4; 604-615; PMCID PMC3081363; 10.1016/j.bbi.2010.12.017
• Southwell, Amber L. and Patterson, Paul H. (2011) Gene Therapy in Mouse Models of Huntington Disease; Neuroscientist; Vol. 17; No. 2; 153-162; PMCID PMC3131092; 10.1177/1073858410386236
• Luong, Tinh N. and Carlisle, Holly J., et el. (2011) Assessment of Motor Balance and Coordination in Mice using the Balance Beam; Journal of Visualized Experiments; No. 49; Art. No. e2376; PMCID PMC3197288; 10.3791/2376
• Brown, Alan S. and Patterson, Paul H. (2011) Maternal Infection and Schizophrenia: Implications for Prevention; Schizophrenia Bulletin; Vol. 37; No. 2; 284-290; PMCID PMC3044639; 10.1093/schbul/sbq146
• Southwell, Amber L. and Bugg, Charles W., et el. (2011) Perturbation with Intrabodies Reveals That Calpain Cleavage Is Required for Degradation of Huntingtin Exon 1; PLoS ONE; Vol. 6; No. 1; Art. No. e16676; PMCID PMC3031625; 10.1371/journal.pone.0016676
• Ito, Hiroshi T. and Smith, Stephen E. P., et el. (2010) Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring; Brain, Behavior, and Immunity; Vol. 24; No. 6; 930-941; PMCID PMC2897971; 10.1016/j.bbi.2010.03.004
• Southwell, Amber L. and Patterson, Paul H. (2010) Antibody therapy in Neurodegenerative Disease; Reviews in the Neurosciences; Vol. 21; No. 4; 273-287; 10.1515/REVNEURO.2010.21.4.273
• Thompson, Leslie Michels and Aiken, Charity T., et el. (2009) IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome; Journal of Cell Biology; Vol. 187; No. 7; 1083-1099; PMCID PMC2806289; 10.1083/jcb.200909067
• Patterson, Paul H. (2009) Immune involvement in schizophrenia and autism: Etiology, pathology and animal models; Behavioural Brain Research; Vol. 204; No. 2; 313-321; 10.1016/j.bbr.2008.12.016
• Stefanescu, Diana M. and Khoshnan, Ali, et el. (2009) Neurotoxicity of manganese oxide nanomaterials; Journal of Nanoparticle Research; Vol. 11; No. 8; 1957-1969; 10.1007/s11051-008-9554-1
• Southwell, Amber L. and Ko, Jan, et el. (2009) Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease; Journal of Neuroscience; Vol. 29; No. 43; 13589-13602; PMCID PMC2822643; 10.1523/JNEUROSCI.4286-09.2009
• Deverman, Benjamin E. and Patterson, Paul H. (2009) Cytokines and CNS Development; Neuron; Vol. 64; No. 1; 61-78; 10.1016/j.neuron.2009.09.002
• Legleiter, Justin and Lotz, Gregor P., et el. (2009) Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment; Journal of Biological Chemistry; Vol. 284; No. 32; 21647-21658; PMCID PMC2755888; 10.1074/jbc.M109.016923
• Khoshnan, Ali and Ko, Jan, et el. (2009) IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin; PLoS ONE; Vol. 4; No. 6; Art. No. e5768; PMCID PMC2685016; 10.1371/journal.pone.0005768
• Khoshnan, Ali and Ko, Jan, et el. (2009) IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin; PLoS ONE; Vol. 4; No. 6; Art. No. e5768; PMCID PMC2685016; 10.1371/journal.pone.0005768
• Gardberg, Anna and Dice, Lezlee, et el. (2009) Structures of Aβ-Related Peptide−Monoclonal Antibody Complexes; Biochemistry; Vol. 48; No. 23; 5210-5217; PMCID PMC2720063; 10.1021/bi9001216
• Shi, Limin and Smith, Stephen E. P., et el. (2009) Activation of the maternal immune system alters cerebellar development in the offspring; Brain, Behavior, and Immunity; Vol. 23; No. 1; 116-123; PMCID PMC2614890; 10.1016/j.bbi.2008.07.012
• Montgomery, Jennifer P. and Patterson, Paul H. (2008) Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor; BMC Cancer; Vol. 8; 354; PMCID PMC2613414; 10.1186/1471-2407-8-354
• Southwell, Amber L. and Khoshnan, Ali, et el. (2008) Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity; Journal of Neuroscience; Vol. 28; No. 36; 9013-9020; PMCID PMC2633448; 10.1523/JNEUROSCI.2747-08.2008
• Patterson, Paul H. (2007) Maternal Effects on Schizophrenia Risk; Science; Vol. 318; No. 5850; 576-577; 10.1126/science.1150196
• Smith, Stephen E. P. and Li, Jennifer, et el. (2007) Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6; Journal of Neuroscience; Vol. 27; No. 40; 10695-10702; PMCID PMC2387067; 10.1523/JNEUROSCI.2178-07.2007
• Gardberg, Anna S. and Dice, Lezlee T., et el. (2007) Molecular basis for passive immunotherapy of Alzheimer's disease; Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 40; 16659-16664; PMCID PMC1994138; 10.1073/pnas.0705888104
• Greger, Bradley and Kateb, Babak, et el. (2007) A chronically implantable, hybrid cannula–electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals; Journal of Neuroscience Methods; Vol. 163; No. 2; 321-325; PMCID PMC2683260; 10.1016/j.jneumeth.2009.01.014
• Bauer, Sylvian and Kerr, Bradley J., et el. (2007) The neuropoietic cytokine family in development, plasticity, disease and injury; Nature Reviews Neuroscience; Vol. 8; No. 3; 221-232; 10.1038/nrn2054
• Bauer, Sylvian and Patterson, Paul H. (2006) Leukemia Inhibitory Factor Promotes Neural Stem Cell Self-Renewal in the Adult Brain; Journal of Neuroscience; Vol. 26; No. 46; 12089-12099; PMCID PMC6674883; 10.1523/JNEUROSCI.3047-06.2006
• Montgomery, Jennifer P. and Patterson, Paul H. (2006) Behavioral Stress and Tumor Progression; Anticancer Research; Vol. 26; No. 2A; 1189-1192
• Holmberg, Kristina H. and Patterson, Paul H. (2006) Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model; Brain Research; Vol. 1075; No. 1; 26-35; 10.1016/j.brainres.2005.12.103
• Bauer, Sylvian and Patterson, Paul H. (2005) The cell cycle–apoptosis connection revisited in the adult brain; Journal of Cell Biology; Vol. 171; No. 4; 641-650; PMCID PMC2171559; 10.1083/jcb.200505072
• Kerr, Bradley J. and Patterson, Paul H. (2005) Leukemia Inhibitory Factor Promotes Oligodendrocyte Survival After Spinal Cord Injury; Glia; Vol. 51; No. 1; 73-79; 10.1002/glia.20177
• Shi, Limin and Tu, Nora, et el. (2005) Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus; International Journal of Developmental Neuroscience; Vol. 23; No. 2-3; 299-305; 10.1016/j.ijdevneu.2004.05.005
• Lahav, Ronit and Suvà, Mario-Luca, et el. (2004) Endothelin Receptor B Inhibition Triggers Apoptosis and Enhances Angiogenesis in Melanomas; Cancer Research; Vol. 64; No. 24; 8945-8953; 10.1158/0008-5472.CAN-04-1510
• Berry, Mark F. and Pirolli, Timothy J., et el. (2004) Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure; Journal of Thoracic and Cardiovascular Surgery; Vol. 128; No. 6; 866-875; 10.1016/j.jtcvs.2004.06.046
• Khoshnan, Ali and Ko, Jan, et el. (2004) Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity; Journal of Neuroscience; Vol. 24; No. 37; 7999-8008; PMCID PMC6729796; 10.1523/JNEUROSCI.2675-04.2004
• Kerr, Bradley J. and Patterson, Paul H. (2004) Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse; Experimental Neurology; Vol. 188; No. 2; 391-407; 10.1016/j.expneurol.2004.04.012
• Watanabe, Yuichiro and Hashimoto, Shinya, et el. (2004) Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats; Neuroscience Research; Vol. 48; No. 3; 345-353; 10.1016/j.neures.2003.12.001
• Armstrong, Brian D. and Hu, Zhongting, et el. (2003) Lymphocyte Regulation of Neuropeptide Gene Expression After Neuronal Injury; Journal of Neuroscience Research; Vol. 74; No. 2; 240-247; 10.1002/jnr.10750
• Bauer, S. and Rasika, S., et el. (2003) Leukemia Inhibitory Factor Is a Key Signal for Injury-Induced Neurogenesis in the Adult Mouse Olfactory Epithelium; Journal of Neuroscience; Vol. 23; No. 5; 1792-1803; PMCID PMC6741956; 10.1523/JNEUROSCI.23-05-01792.2003
• Pichel, Jose G. and Fernández-Moreno, Carmen, et el. (2003) Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1; Mechanisms of Development; Vol. 120; No. 3; 349-361; 10.1016/S0925-4773(02)00449-5
• Shi, Limin and Fatemi, Hossein S., et el. (2003) Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring; Journal of Neuroscience; Vol. 23; No. 1; 297-302; PMCID PMC6742135; 10.1523/JNEUROSCI.23-01-00297.2003
• Tofaris, George K. and Patterson, Paul H., et el. (2002) Denervated Schwann Cells Attract Macrophages by Secretion of Leukemia Inhibitory Factor (LIF) and Monocyte Chemoattractant Protein-1 in a Process Regulated by Interleukin-6 and LIF; Journal of Neuroscience; Vol. 22; No. 15; 6696-6703; PMCID PMC6758146; 10.1523/jneurosci.22-15-06696.2002
• Patterson, Paul H. (2002) Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness; Current Opinion in Neurobiology; Vol. 12; No. 1; 115-118; 10.1016/S0959-4388(02)00299-4
• Fatemi, S. Hossein and Earle, Julie, et el. (2002) Prenatal Viral Infection Leads to Pyramidal Cell Atrophy and Macrocephaly in Adulthood: Implications for Genesis of Autism and Schizophrenia; Cellular and Molecular Neurobiology; Vol. 22; No. 1; 25-33; 10.1023/A:1015337611258
• Khoshnan, Ali and Ko, Jan, et el. (2002) Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity; Proceedings of the National Academy of Sciences of the United States of America; Vol. 99; No. 2; 1002-1007; PMCID PMC117420; 10.1073/pnas.022631799
• Ko, Jan and Ou, Susan, et el. (2001) New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins; Brain Research Bulletin; Vol. 56; No. 3-4; 319-329; 10.1016/S0361-9230(01)00599-8
• Zhu, Min and Oishi, Kazuhiko, et el. (2001) Studies Using Leukemia Inhibitory Factor (LIF) Knockout Mice and a LIF Adenoviral Vector Demonstrate a Key Anti-Inflammatory Role for This Cytokine in Cutaneous Inflammation; Journal of Immunology; Vol. 166; No. 3; 2049-2054; 10.4049/jimmunol.166.3.2049
• Jankowsky, Joanna L. and Patterson, Paul H. (2001) The role of cytokines and growth factors in seizures and their sequelae; Progress in Neurobiology; Vol. 63; No. 2; 125-149; 10.1016/S0301-0082(00)00022-8
• Jankowsky, Joanna L. and Derrick, Brian E., et el. (2000) Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques; Learning and Memory; Vol. 7; No. 6; 400-412; PMCID PMC311345; 10.1101/lm.32600
• Nawa, H. and Takahashi, M., et el. (2000) Cytokine and growth factor involvement in schizophrenia - support for the developmental model; Molecular Psychiatry; Vol. 5; No. 6; 594-603
• de Pablo, Flora and Fernández-Moreno, Carmen, et el. (2000) In vivo functional cooperation of insulin-like growth factor I and leukemia inhibitory factor studied in mutant mice; Developmental Biology; Vol. 222; No. 1; 280; 10.1016/S0012-1606(00)80002-0
• de Pablo, Flora and Banner, Lisa R., et el. (2000) IGF-I expression is decreased in LIF-deficient mice after peripheral nerve injury; Neuroreport; Vol. 11; No. 6; 1365-1368
• Sugiura, Shigeki and Lahav, Ronit, et el. (2000) Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro; European Journal of Neuroscience; Vol. 12; No. 2; 457-466; 10.1046/j.1460-9568.2000.00922.x
• Jankowsky, Joanna L. and Patterson, Paul H. (1999) Differential Regulation of Cytokine Expression Following Pilocarpine-Induced Seizure; Experimental Neurology; Vol. 159; No. 2; 333-346; 10.1006/exnr.1999.7137
• Jankowsky, Joanna L. and Patterson, Paul H. (1999) Cytokine and Growth Factor Involvement in Long-Term Potentiation; Molecular and Cellular Neuroscience; Vol. 14; No. 4-5; 273-286; 10.1006/mcne.1999.0792
• Lahav, Ronit and Heffner, Garrett, et el. (1999) An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo; Proceedings of the National Academy of Sciences of the United States of America; Vol. 96; No. 20; 11496-11500; PMCID PMC18062
• Allendoerfer, Karen L. and Durairaj, Arun, et el. (1999) Morphological Domains of Lewis-X/FORSE-1 Immunolabeling in the Embryonic Neural Tube Are Due to Developmental Regulation of Cell Surface Carbohydrate Expression; Developmental Biology; Vol. 211; No. 2; 208-219; 10.1006/dbio.1999.9308
• Gadient, Reto A. and Patterson, Paul H. (1999) Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury; Stem Cells; Vol. 17; No. 3; 127-137; 10.1002/stem.170127
• Blesch, A. and Uy, H. S., et el. (1999) Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury; Journal of Neuroscience; Vol. 19; No. 9; 3556-3566; PMCID PMC6782234; 10.1523/JNEUROSCI.19-09-03556.1999
• Bugga, Lakshmi and Gadient, Reto A., et el. (1998) Analysis of Neuronal and Glial Phenotypes in Brains of Mice Deficient in Leukemia Inhibitory Factor; Journal of Neurobiology; Vol. 36; No. 4; 509-524; 10.1002/(SICI)1097-4695(19980915)36:4<509::AID-NEU5>3.0.CO;2-#
• Banner, Lisa R. and Patterson, Paul H., et el. (1998) Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine; Journal of Neuroscience; Vol. 18; No. 14; 5456-5462; PMCID PMC6793494; 10.1523/jneurosci.18-14-05456.1998
• Gadient, Reto A. and Lein, Pamela, et el. (1998) Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells; Brain Research; Vol. 798; No. 1-2; 140-146; 10.1016/S0006-8993(98)00236-4
• März, Pia and Cheng, Jr-Gang, et el. (1998) Sympathetic neurons can produce and respond to interleukin 6; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 6; 3251-3256; PMCID PMC19728
• Cheng, Jr-Gang and Pennica, Diane, et el. (1997) Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines; Journal of Neurochemistry; Vol. 69; No. 6; 2278-2284; 10.1046/j.1471-4159.1997.69062278.x
• Ou, Susan Ker-hwa and Patterson, Paul H. (1997) A more efficient and economical approach for monoclonal antibody production; Journal of Immunological Methods; Vol. 209; No. 1; 105-108; 10.1016/S0022-1759(97)00156-7
• Banner, Lisa R. and Moayeri, N. Nicole, et el. (1997) Leukemia Inhibitory Factor Is Expressed in Astrocytes Following Cortical Brain Injury; Experimental Neurology; Vol. 147; No. 1; 1-9; 10.1006/exnr.1997.6536
• Lemke, R. and Gadient, R. A., et el. (1997) Leukemia inhibitory factor (LIF) mRNA-expressing neuronal subpopulations in adult rat basal forebrain; Neuroscience Letters; Vol. 229; No. 1; 69-71; 10.1016/S0304-3940(97)00421-7
• Banerjee, Shilpi A. and Hadjiargyrou, Michael, et el. (1997) An Antibody to the Tetraspan Membrane Protein CD9 Promotes Neurite Formation in a Partially α3β1 Integrin-Dependent Manner; Journal of Neuroscience; Vol. 17; No. 8; 2756-2765; PMCID PMC6573113; 10.1523/JNEUROSCI.17-08-02756.1997
• Cheng, Jr-Gang and Patterson, Paul H. (1997) LIF Is an Autocrine Factor for Sympathetic Neurons; Molecular and Cellular Neuroscience; Vol. 9; No. 5-6; 372-380; 10.1006/mcne.1997.0635
• Hadjiargyrou, Michael and Kaprielian, Zaven, et el. (1996) Association of the Tetraspan Protein CD9 with Integrins on the Surface of S-16 Schwann Cells; Journal of Neurochemistry; Vol. 67; No. 6; 2505-2513; 10.1046/j.1471-4159.1996.67062505.x
• Lemke, R. and Gadient, R. A., et el. (1996) Neuronal expression of leukemia inhibitory factor (LIF) in the rat brain; Neuroscience Letters; Vol. 215; No. 3; 205-208; 10.1016/0304-3940(96)12986-4
• Banerjee, Shilpi A. and Patterson, Paul H. (1995) Schwann Cell CD9 Expression Is Regulated by Axons; Molecular and Cellular Neuroscience; Vol. 6; No. 5; 462-473; 10.1006/mcne.1995.1034
• Patterson, Paul H. (1995) Cytokines in Alzheimer's disease and multiple sclerosis; Current Opinion in Neurobiology; Vol. 5; No. 5; 642-646; 10.1016/0959-4388(95)80070-0
• Allendoerfer, Karen L. and Magnani, John L., et el. (1995) FORSE-1, an Antibody That Labels Regionally Restricted Subpopulations of Progenitor Cells in the Embryonic Central Nervous System, Recognizes the Le^x Carbohydrate on a Proteoglycan and Two Glycolipid Antigens; Molecular and Cellular Neuroscience; Vol. 6; No. 4; 381-395; 10.1006/mcne.1995.1029
• Kou, Shi-Ying and Chiu, Arlene Y., et el. (1995) Differential regulation of motor neuron survival and choline acetyltransferase expression following axotomy; Journal of Neurobiology; Vol. 27; No. 4; 561-572; 10.1002/neu.480270410
• Fann, Ming-Ji and Patterson, Paul H. (1995) Activins as candidate cholinergic differentiation factors in vivo; International Journal of Developmental Neuroscience; Vol. 13; No. 3-4; 317-330; 10.1016/0736-5748(94)00075-E
• Chalmers, Gordon R. and Fisher, Lisa J., et el. (1995) Adrenal Chromaffin Cells Transdifferentiate in Response to Basic Fibroblast Growth Factor and Show Directed Outgrowth to a Nerve Growth Factor Source in Vivo; Experimental Neurology; Vol. 133; No. 1; 32-42; 10.1006/exnr.1995.1005
• Tole, Shubha and Patterson, Paul H. (1995) Regionalization of the Developing Forebrain: A Comparison of FORSE-1, Dlx-2, and BF-1; Journal of Neuroscience; Vol. 15; No. 2; 970-980; PMCID PMC6577806; 10.1523/JNEUROSCI.15-02-00970.1995
• Niijima, Kenji and Chalmers, Gordon R., et el. (1995) Enhanced Survival and Neuronal Differentiation of Adrenal Chromaffin Cells Cografted into the Striatum with NGF-producing Fibroblasts; Journal of Neuroscience; Vol. 15; No. 2; 1180-1194; PMCID PMC6577834; 10.1523/JNEUROSCI.15-02-01180.1995
• Tole, Shubha and Kaprielian, Zaven, et el. (1995) FORSE-1: A Positionally Regulated Epitope in the Developing Rat Central Nervous System; Journal of Neuroscience; Vol. 15; No. 2; 957-969; PMCID PMC6577825; 10.1523/JNEUROSCI.15-02-00957.1995
• Hadjiargyrou, Michael and Patterson, Paul H. (1995) An Anti-CD9 Monoclonal Antibody Promotes Adhesion and Induces Proliferation of Schwann Cells in vitro; Journal of Neuroscience; Vol. 15; No. 1; 574-583; PMCID PMC6578267; 10.1523/JNEUROSCI.15-01-00574.1995
• Anton, Eva S. and Hadjiargyrou, Michael, et el. (1995) CD9 Plays a Role in Schwann Cell Migration in Vitro; Journal of Neuroscience; Vol. 15; No. 1; 584-595; PMCID PMC6578318; 10.1523/jneurosci.15-01-00584.1995
• Kaprielian, Zaven and Cho, Kyung-Ok, et el. (1995) CD9, a Major Platelet Cell Surface Glycoprotein, is a ROCA Antigen and Is Expressed in the Nervous System; Journal of Neuroscience; Vol. 15; No. 1; 562-573; PMCID PMC6578317; 10.1523/JNEUROSCI.15-01-00562.1995
• Fann, Ming-Ji and Patterson, Paul H. (1994) Depolarization Differentially Regulates the Effects of Bone Morphogenetic Protein (BMP)-2, BMP-6, and Activin A on Sympathetic Neuronal Phenotype; Journal of Neurochemistry; Vol. 63; No. 6; 2074-2079; 10.1046/j.1471-4159.1994.63062074.x
• Ulich, Thomas R. and Fann, Ming-Ji, et el. (1994) Intratracheal injection of LPS and cytokines. V. LPS induces expression of LIF and LIF inhibits acute inflammation; APJ-Lung Cellular and Molecular Physiology; Vol. 267; No. 4; L442-L446
• Patterson, Paul H. (1994) Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 17; 7833-7835; PMCID PMC44497
• Banner, Lisa R. and Patterson, Paul H. (1994) Major Changes in the Expression of the mRNAs for Cholinergic Differentiation Factor/Leukemia Inhibitory Factor and its Receptor After Injury to Adult Peripheral Nerves and Ganglia; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 15; 7109-7113; PMCID PMC44348
• Fann, Ming-Ji and Patterson, Paul H. (1994) Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 1; 43-47; PMCID PMC42882
• Kaprielian, Zaven and Patterson, Paul H. (1994) The molecular basis of retinotectal topography; BioEssays; Vol. 16; No. 1; 1-11; 10.1002/bies.950160102
• Rao, M. S. and Sun, Y., et el. (1993) Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons; Neuron; Vol. 11; No. 6; 1175-1185; 10.1016/0896-6273(93)90229-K
• Ou, Susan Ker-hwa and Hwang, Jenny Ming-chen, et el. (1993) A modified method for obtaining large amounts of high titer polyclonal ascites fluid; Journal of Immunological Methods; Vol. 165; No. 1; 75-80; 10.1016/0022-1759(93)90108-J
• Patterson, Paul H. (1993) Les cytokines et le fonctionnement du système nerveux mature; Comptes rendus de l'Académie des sciences, Série 3, Sciences de la vie; Vol. 316; No. 9; 1141-1149
• Patterson, Paul H. (1993) Cytokines and the function of the mature nervous system; Comptes rendus de l'Académie des sciences, Série 3, Sciences de la vie; Vol. 316; 1150-1157
• Kaprielian, Zaven and Patterson, Paul H. (1993) Surface and Cytoskeletal Markers of Rostrocaudal Position in the Mammalian Nervous System; Journal of Neuroscience; Vol. 13; No. 6; 2495-2506; PMCID PMC6576506; 10.1523/JNEUROSCI.13-06-02495.1993
• Tole, Shubha and Patterson, Paul H. (1993) Distribution of CD9 in the Developing and Mature Rat Nervous System; Developmental Dynamics; Vol. 197; No. 2; 94-106; 10.1002/aja.1001970203
• Patterson, Paul H. and Nawa, Hiroyuki (1993) Neuronal differentiation factors/cytokines and synaptic plasticity; Cell; Vol. 72; No. S; 123-137; 10.1016/S0092-8674(05)80032-7
• Patterson, Paul H. (1992) New blossoms in the neural crest field: trophic and transcription factors; Current Opinion in Cell Biology; Vol. 4; No. 6; 962-966; 10.1016/0955-0674(92)90125-V
• Rao, M. S. and Patterson, Paul H., et el. (1992) Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors; Development; Vol. 116; No. 3; 731-744
• Rao, M. and Patterson, P. H., et el. (1992) Membrane-Associated Neurotransmitter Stimulating Factor is Very Similar to Ciliary Neurotrophic Factor; Developmental Biology; Vol. 153; No. 2; 411-416; 10.1016/0012-1606(92)90127-3
• Rao, M. S. and Tyrrell, S., et el. (1992) Effects of Ciliary Neurotrophic Factor (CNTF) and Depolarization on Neuropeptide Expression in Cultured Sympathetic Neurons; Developmental Biology; Vol. 150; No. 2; 281-293; 10.1016/0012-1606(92)90242-9
• Mahanthappa, Nagesh K. and Patterson, Paul H. (1992) Thy-1 Involvement in Neurite Outgrowth: Perturbation by Antibodies, Phospholipase C, and Mutation; Developmental Biology; Vol. 150; No. 1; 47-59; 10.1016/0012-1606(92)90006-3
• Patterson, Paul H. (1992) The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?; Current Opinion in Neurobiology; Vol. 2; No. 1; 94-97; 10.1016/0959-4388(92)90169-L
• Ou, Susan Ker-hwa and McDonald, Colin, et el. (1991) Comparison of two techniques for targeting the production of monoclonal antibodies against particular antigens; Journal of Immunological Methods; Vol. 145; No. 1-2; 111-118; 10.1016/0022-1759(91)90316-8
• Carnahan, Josette F. and Anderson, David J., et el. (1991) Evidence That Enteric Neurons May Derive from the Sympathoadrenal Lineage; Developmental Biology; Vol. 148; No. 2; 552-561; 10.1016/0012-1606(91)90273-6
• Carnahan, Josette F. and Patterson, Paul H. (1991) Isolation of the Progenitor Cells of the Sympathoadrenal Lineage from Embryonic Sympathetic Ganglia with the SA Monoclonal Antibodies; Journal of Neuroscience; Vol. 11; No. 11; 3520-3530; PMCID PMC6575542; 10.1523/JNEUROSCI.11-11-03520.1991
• Carnahan, Josette F. and Patterson, Paul H. (1991) The Generation of Monoclonal Antibodies that Bind Preferentially to Adrenal Chromaffin Cells and the Cells of Embryonic Sympathetic Ganglia; Journal of Neuroscience; Vol. 11; No. 11; 3493-3506; PMCID PMC6575556; 10.1523/JNEUROSCI.11-11-03493.1991
• Anderson, David J. and Carnahan, Josette F., et el. (1991) Antibody Markers Identify a Common Progenitor to Sympathetic Neurons and Chromaffin Cells in vivo and Reveal the Timing of Commitment to Neuronal Differentiation in the Sympathoadrenal Lineage; Journal of Neuroscience; Vol. 11; No. 11; 3507-3519; PMCID PMC6575531; 10.1523/JNEUROSCI.11-11-03507.1991
• Nawa, Hiroyuki and Nakanishi, Shigetada, et el. (1991) Recombinant Cholinergic Differentiation Factor (Leukemia Inhibitory Factor) Regulates Sympathetic Neuron Phenotype by Alterations in the Size and Amounts of Neuropeptide mRNAs; Journal of Neurochemistry; Vol. 56; No. 6; 2147-2150; 10.1111/j.1471-4159.1991.tb03479.x
• Suzue, Toshihiko and Kaprielian, Zaven, et el. (1990) A Monoclonal Antibody That Defines Rostrocaudal Gradients in the Mammalian Nervous System; Neuron; Vol. 5; No. 4; 421-431; 10.1016/0896-6273(90)90081-P
• Patterson, Paul H. (1990) Control of Cell Fate in a Vertebrate Neurogenic Lineage; Cell; Vol. 62; No. 6; 1035-1038; 10.1016/0092-8674(90)90379-S
• Rao, Mahendra S. and Landis, Story C., et el. (1990) The Cholinergic Neuronal Differentiation Factor from Heart Cell Conditioned Medium Is Different from the Cholinergic Factors in Sciatic Nerve and Spinal Cord; Developmental Biology; Vol. 139; No. 1; 65-74; 10.1016/0012-1606(90)90279-R
• Nawa, Hiroyuki and Patterson, Paul H. (1990) Separation and Partial Characterization of Neuropeptide-lnducing Factors in Heart Cell Conditioned Medium; Neuron; Vol. 4; No. 2; 269-277; 10.1016/0896-6273(90)90101-K
• Nawa, H. and Yamamori, T., et el. (1990) Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 55; 247-253; 10.1101/SQB.1990.055.01.027
• Yamamori, Tetsuo and Fukada, Keiko, et el. (1989) The Cholinergic Neuronal Differentiation Factor from Heart Cells is Identical to Leukemia Inhibitory Factor; Science; Vol. 246; No. 4936; 1412-1416; 10.1126/science.2512641
• Patterson, Paul H. (1988) On the importance of being inhibited, or saying no to growth cones; Neuron; Vol. 1; No. 4; 263-267; 10.1016/0896-6273(88)90074-8
• Pittman, Randall N. and Patterson, Paul H. (1987) Characterization of an Inhibitor of Neuronal Plasminogen Activator Released by Heart Cells; Journal of Neuroscience; Vol. 7; No. 9; 2664-2673; PMCID PMC6569127; 10.1523/jneurosci.07-09-02664.1987
• Patterson, Paul H. (1987) The Molecular Basis of Phenotypic Choices in the Sympathoadrenal Lineage; Annals of the New York Academy of Sciences; Vol. 493; 20-26; 10.1111/j.1749-6632.1987.tb27177.x
• Pintar, John E. and Breakefield, Xandra O., et el. (1987) Differences in Monoamine Oxidase Activity between Cultured Noradrenergic and Cholinergic Sympathetic Neurons; Developmental Biology; Vol. 120; No. 1; 305-308; 10.1016/0012-1606(87)90128-X
• Chiu, Arlene Y. and Matthew, William D., et el. (1986) A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: studies on the binding site and its localization in vivo; Journal of Cell Biology; Vol. 103; No. 4; 1383-1398; PMCID PMC2114357
• Doupe, Allison J. and Patterson, Paul H., et el. (1985) Small Intensely Fluorescent Cells in Culture: Role of Glucocorticoids and Growth Factors in Their Development and lnterconversions with other Neural Crest Derivatives; Journal of Neuroscience; Vol. 5; No. 8; 2143-2160; PMCID PMC6565283; 10.1523/jneurosci.05-08-02143.1985
• Doupe, Allison J. and Landis, Story C., et el. (1985) Environmental Influences in the Development of Neural Crest Derivatives: Glucocorticoids, Growth Factors, and Chromaffin Cell Plasticity; Journal of Neuroscience; Vol. 5; No. 8; 2119-2142; PMCID PMC6565296; 10.1523/jneurosci.05-08-02119.1985
• Wolinsky, Eve J. and Patterson, Paul H., et el. (1985) Insulin Promotes Electrical Coupling between Cultured Sympathetic Neurons; Journal of Neuroscience; Vol. 5; No. 7; 1675-1679; PMCID PMC6565121; 10.1523/jneurosci.05-07-01675.1985
• Wolinsky, Eve J. and Patterson, Paul H. (1985) Potassium-stimulated Purine Release by Cultured Sympathetic Neurons; Journal of Neuroscience; Vol. 5; No. 7; 1680-1687; PMCID PMC6565105; 10.1523/jneurosci.05-07-01680.1985
• Wolinsky, Eve J. and Patterson, Paul H. (1985) Rat Serum Contains a Developmentally Regulated Cholinergic Inducing Activity; Journal of Neuroscience; Vol. 5; No. 6; 1509-1512; PMCID PMC6565265; 10.1523/jneurosci.05-06-01509.1985
• Wolinsky, Eve J. and Landis, Story C., et el. (1985) Expression of Noradrenergic and Cholinergic Traits by Sympathetic Neurons Cultured without Serum; Journal of Neuroscience; Vol. 5; No. 6; 1497-1508; PMCID PMC6565262; 10.1523/jneurosci.05-06-01497.1985
• Patterson, Paul H. (1985) On the role of proteases, their inhibitors and the extracellular matrix in promoting neurite outgrowth; Journal de Physiologie; Vol. 80; No. 4; 207-211
• Wolinsky, Eve and Patterson, Paul H. (1983) Tyrosine hydroxylase activity decreases with induction of cholinergic properties in cultured sympathetic neurons; Journal of Neuroscience; Vol. 3; No. 7; 1495-1500; PMCID PMC6564433; 10.1523/jneurosci.03-07-01495.1983
• Matthew, W. D. and Patterson, P. H. (1983) The Production of a Monoclonal Antibody That Blocks the Action of a Neurite Outgrowth-promoting Factor; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 48; 625-631; 10.1101/SQB.1983.048.01.066
• Braun, Sarah J. and Sweadner, Kathleen J., et el. (1981) Neuronal cell surfaces: distinctive glycoproteins of cultured adrenergic and cholinergic sympathetic neurons; Journal of Neuroscience; Vol. 1; No. 12; 1397-1406; PMCID PMC6564125; 10.1523/jneurosci.01-12-01397.1981
• Walicke, Patricia A. and Patterson, Paul H. (1981) On the role of Ca^(2+) in the transmitter choice made by cultured sympathetic neurons; Journal of Neuroscience; Vol. 1; No. 4; 343-350; PMCID PMC6564140; 10.1523/jneurosci.01-04-00343.1981
• Walicke, Patricia A. and Patterson, Paul H. (1981) On the role of cyclic nucleotides in the transmitter choice made by cultured sympathetic neurons; Journal of Neuroscience; Vol. 1; No. 4; 333-342; PMCID PMC6564134; 10.1523/jneurosci.01-04-00333.1981
• Chun, Linda L. Y. and Patterson, Paul H., et el. (1980) Preliminary Studies on the Use of Monoclonal Antibodies as Probes for Sympathetic Development; Journal of Experimental Biology; Vol. 89; 73-83
• Potter, David D. and Furshpan, Edwin J., et el. (1978) The chemical differentiation of nerve cells; Scientific American; Vol. 239; No. 1; 50-59
• Walicke, Patricia A. and Campenot, Robert B., et el. (1977) Determination of transmitter function by neuronal activity; Proceedings of the National Academy of Sciences of the United States of America; Vol. 74; No. 12; 5767-5771; PMCID PMC431875
• Chun, Linda L. Y. and Patterson, Paul H. (1977) Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production; Journal of Cell Biology; Vol. 75; No. 3; 694-704; PMCID PMC2111592; 10.1083/jcb.75.3.712
• Reichardt, L. F. and Patterson, P. H. (1977) Neurotransmitter synthesis and uptake by isolated sympathetic neurones in microcultures; Nature; Vol. 270; No. 5633; 147-151; 10.1038/270147a0
• Patterson, Paul H. and Chun, Linda L. Y. (1977) The induction of acetylcholine synthesis in primary cultures of dissociated rat sympathetic neurons; Developmental Biology; Vol. 60; No. 2; 473-481; 10.1016/0012-1606(77)90144-0
• Patterson, Paul H. and Chun, Linda L. Y. (1977) The Induction of Acetylcholine Synthesis in Primary Cultures of Dissociated Rat Sympathetic Neurons I. Effects of Conditioned Medium; Developmental Biology; Vol. 56; No. 2; 263-280; 10.1016/0012-1606(77)90269-X
• Patterson, Paul H. and Chun, Linda L. Y. (1974) The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons; Proceedings of the National Academy of Sciences of the United States of America; Vol. 71; No. 9; 3607-3610; PMCID PMC433824
• Patterson, Paul H. and Lennarz, W. J. (1970) Novel protein composition of a bacterial membrane; Biochemical and Biophysical Research Communications; Vol. 40; No. 2; 408-415; 10.1016/0006-291X(70)91024-7