Rothenberg, Ellen

Article from CaltechAUTHORS

• Shin, Boyoung and Chang, Samantha J., et el. (2024) Transcriptional network dynamics in early T cell development; Journal of Experimental Medicine; Vol. 221; No. 10; e20230893; 10.1084/jem.20230893
• Andersson, Emil and Rothenberg, Ellen V., et el. (2024) T-cell commitment inheritance—an agent-based multi-scale model; npj Systems Biology and Applications; Vol. 10; 40; PMCID PMC11024127; 10.1038/s41540-024-00368-y
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• MacNabb, Brendan W. and Rothenberg, Ellen V. (2023) Speed and navigation control of thymocyte development by the fetal T-cell gene regulatory network; Immunological Reviews; Vol. 315; No. 1; 171-196; PMCID PMC10771342; 10.1111/imr.13190
• Kagan, Jonathan C. and Rothenberg, Ellen V., et el. (2023) Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology; Trends in Immunology; Vol. 44; No. 4; 248-255; 10.1016/j.it.2023.02.003
• Shin, Boyoung and Rothenberg, Ellen V. (2023) Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells; Frontiers in Immunology; Vol. 14; Art. No. 1108368; PMCID PMC9928580; 10.3389/fimmu.2023.1108368
• Rothenberg, Ellen V. (2022) Transcription factors specifically control change; Genes and Development; Vol. 36; No. 21-24; 1097-1099; PMCID PMC9851400; 10.1101/gad.350308.122
• Rothenberg, Ellen V. (2022) The Heart of the Machine: Construction of T Cell Identity, Made Accessible; Journal of Immunology; Vol. 209; No. 7; 1235-1236; 10.4049/jimmunol.2200264
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• Rothenberg, Ellen V. (2021) Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment; Biophysical Journal; Vol. 120; No. 19; 4162-4181; 10.1016/j.bpj.2021.04.002
• Hosokawa, Hiroyuki and Koizumi, Maria, et el. (2021) Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells; Journal of Experimental Medicine; Vol. 218; No. 8; Art. No. e20202648; PMCID PMC8241539; 10.1084/jem.20202648
• Sidwell, Tom and Rothenberg, Ellen V. (2021) Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b; Frontiers in Immunology; Vol. 12; Art. No. 669498; PMCID PMC8079813; 10.3389/fimmu.2021.669498
• Hosokawa, Hiroyuki and Rothenberg, Ellen V. (2021) How transcription factors drive choice of the T cell fate; Nature Reviews. Immunology; Vol. 21; No. 3; 162-176; 10.1038/s41577-020-00426-6
• Rothenberg, Ellen V. (2021) Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human; Experimental Hematology; Vol. 95; 1-12; PMCID PMC8018899; 10.1016/j.exphem.2020.12.005
• Shin, Boyoung and Hosokawa, Hiroyuki, et el. (2021) Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching; Proceedings of the National Academy of Sciences of the United States of America; Vol. 118; No. 4; Art. No. e2019655118; PMCID PMC7848575; 10.1073/pnas.2019655118
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• Rothenberg, Ellen V. and Göttgens, Berthold (2021) How haematopoiesis research became a fertile ground for regulatory network biology as pioneered by Eric Davidson; Current Opinion in Hematology; Vol. 28; No. 1; 1-10; PMCID PMC7755131; 10.1097/moh.0000000000000628
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• Wang, Xun and Rothenberg, Ellen V. (2020) Illuminating the core of adaptive immunity—how the regulatory genome controls Rag chromatin dynamics; Science Immunology; Vol. 5; No. 51; Art. No. eabd6427; 10.1126/sciimmunol.abd6427
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• Rothenberg, Ellen V. (2019) Dynamic control of the T-cell specification gene regulatory network; Current Opinion in Systems Biology; Vol. 18; 62-76; PMCID PMC7015151; 10.1016/j.coisb.2019.10.012
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• Hosokawa, Hiroyuki and Rothenberg, Ellen V. (2018) Cytokines, Transcription Factors, and the Initiation of T-Cell Development; Cold Spring Harbor Perspectives in Biology; Vol. 10; No. 5; 1-19; PMCID PMC5876153; 10.1101/cshperspect.a028621
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• Warren, Luigi A. and Rothenberg, Ellen V. (2003) Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors; Current Opinion in Immunology; Vol. 15; No. 2; 166-175; 10.1016/S0952-7915(03)00011-6
• Rothenberg, Ellen V. (2002) T-lineage specification and commitment: a gene regulation perspective; Seminars in Immunology; Vol. 14; No. 6; 431-440; 10.1016/S1044532302000787
• Rothenberg, Ellen V. and Dionne, Christopher J. (2002) Lineage plasticity and commitment in T-cell development; Immunological Reviews; Vol. 187; No. 1; 96-115; 10.1034/j.1600-065X.2002.18709.x
• Anderson, Michele K. and Hernandez-Hoyos, Gabriela, et el. (2002) Definition of Regulatory Network Elements for T Cell Development by Perturbation Analysis with PU.1 and GATA-3; Developmental Biology; Vol. 246; No. 1; 103-121; 10.1006/dbio.2002.0674
• Rothenberg, Ellen V. and Anderson, Michele K. (2002) Elements of Transcription Factor Network Design for T-Lineage Specification; Developmental Biology; Vol. 246; No. 1; 29-44; 10.1006/dbio.2002.0667
• Anderson, Michele K. and Weiss, Angela H., et el. (2002) Constitutive Expression of PU.1 in Fetal Hematopoietic Progenitors Blocks T Cell Development at the Pro-T Cell Stage; Immunity; Vol. 16; No. 2; 285-296; 10.1016/S1074-7613(02)00277-7
• Rothenberg, Ellen V. (2001) Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 12; 6540-6542; PMCID PMC34387
• Makita, Takako and Hernandez-Hoyos, Gabriela, et el. (2001) A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4; Genes and Development; Vol. 15; No. 7; 889-901; PMCID PMC312661; 10.1101/gad.871601
• Miracle, Ann L. and Anderson, Michele K., et el. (2001) Complex expression patterns of lymphocyte-specific genes during the development of cartilaginous fish implicate unique lymphoid tissues in generating an immune repertoire; International Immunology; Vol. 13; No. 4; 567-580; 10.1093/intimm/13.4.567
• Rothenberg, Ellen V. (2001) Notchless T cell maturation?; Nature Immunology; Vol. 2; No. 3; 189-190; 10.1038/85231
• Chen, Fei and Rowen, Lee, et el. (2001) Differential Transcriptional Regulation of Individual TCR V Segments Before Gene Rearrangement; Journal of Immunology; Vol. 166; No. 3; 1771-1780; 10.4049/jimmunol.166.3.1771
• Yui, Mary A. and Hernández-Hoyos, Gabriela, et el. (2001) A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression; Journal of Immunology; Vol. 166; No. 3; 1730-1739; 10.4049/jimmunol.166.3.1730
• Anderson, Michele K. and Sun, Xiao, et el. (2001) Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 2; 553-558; PMCID PMC14625; 10.1073/pnas.021478998
• Telfer, Janice C. and Rothenberg, Ellen V. (2001) Expression and Function of a Stem Cell Promoter for the Murine CBFα2 Gene: Distinct Roles and Regulation in Natural Killer and T Cell Development; Developmental Biology; Vol. 229; No. 2; 363-382; 10.1006/dbio.2000.9991
• Rothenberg, Ellen V. (2000) Stepwise specification of lymphocyte developmental lineages; Current Opinion in Genetics and Development; Vol. 10; No. 4; 370-379; 10.1016/S0959-437X(00)00098-8
• Hernández-Hoyos, Gabriela and Sohn, Sue J., et el. (2000) Lck Activity Controls CD4/CD8 T Cell Lineage Commitment; Immunity; Vol. 12; No. 3; 313-322; 10.1016/S1074-7613(00)80184-3
• Rothenberg, Ellen V. and Telfer, Janice C., et el. (1999) Transcriptional regulation of lymphocyte lineage commitment; Bioessays; Vol. 21; No. 9; 726-742; 10.1002/(SICI)1521-1878(199909)21:9<726::AID-BIES4>3.0.CO;2-S
• Anderson, Michele K. and Hernandez-Hoyos, Gabriela, et el. (1999) Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage; Development; Vol. 126; No. 14; 3131-3148
• Chen, Fei and Chen, Dan, et el. (1999) Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints; International Immunology; Vol. 11; No. 5; 677-688; 10.1093/intimm/11.5.677
• Wang, Hua and Diamond, Rochelle A., et el. (1998) Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment; International Immunology; Vol. 10; No. 11; 1623-1635; 10.1093/intimm/10.11.1623
• Ward, Susan B. and Hernandez-Hoyos, Gabriela, et el. (1998) Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions; Nucleic Acids Research; Vol. 26; No. 12; 2923-2934; PMCID PMC147656
• Wang, Hua and Diamond, Rochelle A., et el. (1998) Cross-lineage expression of Ig-beta (B29) in thymocytes: Positive and negative gene regulation to establish T cell identity; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 12; 6831-6836; PMCID PMC22652
• Yang-Snyder, Julia A. and Rothenberg, Ellen V. (1998) Spontaneous Expression of Interleukin-2 In Vivo in Specific Tissues of Young Mice; Developmental Immunology; Vol. 5; No. 4; 223-245; PMCID PMC2275993; 10.1155/1998/12421
• Diamond, Rochelle A. and Ward, Susan B., et el. (1997) Different Developmental Arrest Points in RAG-2 -/- and SCID Thymocytes on Two Genetic Backgrounds Developmental Choices and Cell Death Mechanisms before TCR Gene Rearrangement; Journal of Immunology; Vol. 158; No. 9; 4052-4064
• Rothenberg, Ellen V. and Ward, Susan B. (1996) A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 18; 9358-9365; PMCID PMC38432
• Rothenberg, Ellen V. (1996) How T Cells Count; Science; Vol. 273; No. 5271; 78-79; 10.1126/science.273.5271.78
• Reya, Tannishtha and Yang-Snyder, Julia A., et el. (1996) Regulated expression and function of CD122 (interleukin-2/interleukin-15R-β) during lymphoid development; Blood; Vol. 87; No. 1; 190-201
• Lindenboim, Liora and Diamond, Rochelle, et el. (1995) Apoptosis Induced by Serum Deprivation of PC12 Cells Is Not Preceded by Growth Arrest and Can Occur at Each Phase of the Cell Cycle; Cancer Research; Vol. 55; No. 6; 1242-1247
• Rothenberg, Ellen V. (1994) Signaling mechanisms in thymocyte selection; Current Opinion in Immunology; Vol. 6; No. 2; 257-265; 10.1016/0952-7915(94)90099-X
• Chen, Dan and Rothenberg, Ellen V. (1994) Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles; Journal of Experimental Medicine; Vol. 179; No. 3; 931-942; PMCID PMC2191402; 10.1084/jem.179.3.931
• Garrity, Paul A. and Chen, Dan, et el. (1994) Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors; Molecular and Cellular Biology; Vol. 14; No. 3; 2159-2169; PMCID PMC358576; 10.1128/MCB.14.3.2159
• Rothenberg, Ellen V. and Diamond, Rochelle A. (1994) Costimulation by interleukin-1 of multiple activation responses in a developmentally restricted subset of immature thymocytes; European Journal of Immunology; Vol. 24; No. 1; 24-33; 10.1002/eji.1830240105
• Rothenberg, Ellen V. and Chen, Dan, et el. (1993) Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point; Journal of Immunology; Vol. 151; No. 7; 3530-3546
• Chen, Dan and Rothenberg, Ellen V. (1993) Molecular basis for developmental changes in interleukin-2 gene inducibility; Molecular and Cellular Biology; Vol. 13; No. 1; 228-237; PMCID PMC358902
• Yang-Snyder, Julia A. and Rothenberg, Ellen V. (1993) Developmental and Anatomical Patterns Of IL-2 Gene Expression in Vivo in The Murine Thymus; Developmental Immunology; Vol. 3; No. 2; 85-102; PMCID PMC2275923; 10.1155/1993/86096
• Novak, Thomas J. and Yoshimura, Fayth K., et el. (1992) In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters; Molecular and Cellular Biology; Vol. 12; No. 4; 1515-1527; PMCID PMC369593
• Novak, Thomas J. and Rothenberg, Ellen V. (1990) cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells; Proceedings of the National Academy of Sciences of the United States of America; Vol. 87; No. 23; 9353-9357; PMCID PMC55163; 10.1073/pnas.87.23.9353
• Novak, Thomas J. and Chen, Dan, et el. (1990) Interleukin-1 Synergy with Phosphoinositide Pathway Agonists for Induction of Interleukin-2 Gene Expression: Molecular Basis of Costimulation; Molecular and Cellular Biology; Vol. 10; No. 12; 6325-6334; PMCID PMC362908
• Novak, Thomas J. and White, Patricia M., et el. (1990) Regulatory anatomy of the murine interleukin-2 gene; Nucleic Acids Research; Vol. 18; No. 15; 4523-4533; PMCID PMC331273; 10.1093/nar/18.15.4523
• Rothenberg, Ellen V. (1990) Death and transfiguration of cortical thymocytes: a reconsideration; Immunology Today; Vol. 11; No. 4; 116-119; 10.1016/0167-5699(90)90047-D
• Rothenberg, Ellen V. and Diamond, Rochelle A., et el. (1990) IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation; Journal of Immunology; Vol. 144; No. 5; 1614-1624
• Boyer, Paul D. and Diamond, Rochelle A., et el. (1989) Changes in inducibility of IL-2 receptor alpha-chain and T cell-receptor expression during thymocyte differentiation in the mouse; Journal of Immunology; Vol. 142; No. 12; 4124-4130
• Rothenberg, Ellen V. (1989) The long road to functional maturity for developing T cells; Immunology Today; Vol. 10; No. 4; 116-117; 10.1016/0167-5699(89)90243-0
• McGuire, Kathleen L. and Yang, Julia A., et el. (1988) Influence of activating stimulus on functional phenotype: Interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells; Proceedings of the National Academy of Sciences of the United States of America; Vol. 85; No. 17; 6503-6507; PMCID PMC282001
• Rothenberg, Ellen V. and McGuire, Kathleen L., et el. (1988) Molecular Indices of Functional Competence in Developing T Cells; Immunological Reviews; Vol. 104; No. 1; 29-53; 10.1111/j.1600-065X.1988.tb00758.x
• Boyer, Paul D. and Rothenberg, Ellen V. (1988) IL-2 receptor inducibility is blocked in cortical-type thymocytes; Journal of Immunology; Vol. 140; No. 9; 2886-2892
• Kinnon, Christine and McGuire, Kathleen L., et el. (1987) Differential regulation of T cell receptor gamma genes in immature thymocyte populations; European Journal of Immunology; Vol. 17; No. 9; 1265-1269; 10.1002/eji.1830170908
• McGuire, Kathleen L. and Rothenberg, Ellen V. (1987) Inducibility of interleukin-2 RNA expression in individual mature and immature T lymphocytes; EMBO Journal; Vol. 6; No. 4; 939-946; PMCID PMC553486
• Haas, Martin and Altman, Amnon, et el. (1987) Radiation leukemia virus and X-irradiation induce in C57BL/6 mice two distinct T-cell neoplasms: A growth factor-dependent lymphoma and a growth factor-independent lymphoma; Leukemia Research; Vol. 11; No. 3; 223-239; 10.1016/0145-2126(87)90046-4
• Kinnon, Christine and Diamond, Rochelle A., et el. (1986) Activation of T cell antigen receptor alpha- and beta-chain genes in the thymus: implications for the lineages of developing cortical thymocytes; Journal of Immunology; Vol. 137; No. 12; 4010-4015
• Lugo, James P. and Krishnan, Santosh N., et el. (1986) Early Precursor Thymocytes Can Produce Interleukin 2 upon Stimulation with Calcium Ionophore and Phorbol Ester; Proceedings of the National Academy of Sciences of the United States of America; Vol. 83; No. 6; 1862-1866; PMCID PMC323184
• Rothenberg, Ellen and Lugo, James P. (1985) Differentiation and cell division in the mammalian thymus; Developmental Biology; Vol. 112; No. 1; 1-17; 10.1016/0012-1606(85)90114-9
• Lugo, J. P. and Krishnan, S. N., et el. (1985) Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition; Journal of Experimental Medicine; Vol. 161; No. 5; 1048-1062; PMCID PMC2187600; 10.1084/jem.161.5.1048
• Caplan, Barry and Rothenberg, Ellen (1984) High-level secretion of interleukin 2 by a subset of proliferating thymic lymphoblasts; Journal of Immunology; Vol. 133; No. 4; 1983-1991
• Haas, Martin and Altman, Amnon, et el. (1984) Mechanism of T-Cell Lymphomagenesis: Transformation of Growth-Factor-Dependent T-Lymphoblastoma Cells to Growth-Factor-Independent T-Lymphoma Cells; Proceedings of the National Academy of Sciences of the United States of America; Vol. 81; No. 6; 1742-1746; PMCID PMC344995
• Rothenberg, Ellen and Triglia, Dennis (1983) Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice; Journal of Immunology; Vol. 130; No. 4; 1627-1633
• Rothenberg, E. and Triglia, D. (1983) Lyt-2 glycoprotein is synthesized as a single molecular species; Journal of Experimental Medicine; Vol. 157; No. 1; 365-370; PMCID PMC2186898; 10.1084/jem.157.1.365
• Rothenberg, Ellen (1982) What is the role of T-lymphocyte surveillance in neoplastic disease?; American Journal of Surgery; Vol. 143; No. 6; 664-669; 10.1016/0002-9610(82)90032-0
• Rothenberg, Ellen (1982) A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells; Journal of Experimental Medicine; Vol. 155; No. 1; 140-154; PMCID PMC2186575; 10.1084/jem.155.1.140
• Rothenberg, Ellen and Triglia, Dennis (1981) Structure and expression of glycoproteins controlled by the Qa-1^a allele; Immunogenetics; Vol. 14; No. 6; 455-468; 10.1007/BF00350118
• Triglia, Dennis and Rothenberg, Ellen V. (1981) "Mature" thymocytes are not glucocorticoid-resistant in vitro; Journal of Immunology; Vol. 127; No. 1; 64-68
• Michaelson, James and Rothenberg, Ellen, et el. (1980) Genetic polymorphism of murineβ_2-microglobulin detected biochemically; Immunogenetics; Vol. 11-11; No. 1; 93-95; 10.1007/BF01567773
• Rothenberg, Ellen (1980) Expression of Differentiation Antigens in Subpopulations of Mouse Thymocytes: Regulation at the Level of de Novo Synthesis; Cell; Vol. 20; No. 1; 1-9; 10.1016/0092-8674(80)90228-7
• Rothenberg, Ellen and Triglia, Dennis (1980) In vitro maintenance of differentiation marker synthesis by subpopulations of mouse thymocytes; Journal of Supramolecular Structure; Vol. 14; No. 3; 371-382; 10.1002/jss.400140310
• Rothenberg, E. and Boyser, Edward A. (1979) Synthesis and processing of molecules bearing thymus leukemia antigen; Journal of Experimental Medicine; Vol. 150; No. 4; 777-791; PMCID PMC2185687; 10.1084/jem.150.4.777
• Baltimore, D. and Gilboa, E., et el. (1979) Production of a Discrete, Infectious, Double-stranded DNA by Reverse Transcription in Virions of Moloney Murine Leukemia Virus; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 43; No. 0; 869-874; 10.1101/SQB.1979.043.01.093
• Donoghue, Daniel J. and Rothenberg, Ellen, et el. (1978) Heteroduplex Analysis of the Nonhomology Region between Moloney MuLV and the Dual Host Range Derivative HIX Virus; Cell; Vol. 14; No. 4; 959-970; 10.1016/0092-8674(78)90350-1
• Shields, Anthony and Witte, Owen N., et el. (1978) High frequency of aberrant expression of moloney murine leukemia virus in clonal infections; Cell; Vol. 14; No. 3; 601-609; 10.1016/0092-8674(78)90245-3
• Rothenberg, Ellen and Donoghue, Daniel J., et el. (1978) Analysis of a 5' Leader Sequence on Murine Leukemia Virus 21S RNA: Heteroduplex Mapping with Long Reverse Transcriptase Products; Cell; Vol. 13; No. 3; 435-451; 10.1016/0092-8674(78)90318-5
• Rothenberg, Ellen and Smotkin, David, et el. (1977) In vitro synthesis of infectious DNA of murine leukaemia virus; Nature; Vol. 269; No. 5624; 122-126; 10.1038/269122a0
• Rothenberg, Ellen and Baltimore, David (1977) Increased Length of DNA Made by Virions of Murine Leukemia Virus at Limiting Magnesium Ion Concentration; Journal of Virology; Vol. 21; No. 1; 168-178; PMCID PMC353803
• Haseltine, William A. and Kleid, Dennis G., et el. (1976) Ordered transcription of RNA tumor virus genomes; Journal of Molecular Biology; Vol. 106; No. 1; 109-131; 10.1016/0022-2836(76)90303-X
• Rothenberg, Ellen and Baltimore, David (1976) Synthesis of Long, Representative DNA Copies of the Murine RNA Tumor Virus Genome; Journal of Virology; Vol. 17; No. 1; 168-174; PMCID PMC515400