Varshavsky, Alexander
- Varshavsky, Alexander (2024) N-degron pathways; Proceedings of the National Academy of Sciences; Vol. 121; No. 39; e2408697121; 10.1073/pnas.2408697121
- Varshavsky, Alexander and Lewis, Kim, et el. (2023) Deletions of DNA in cancer and their possible uses for therapy; Bioessays; Vol. 45; No. 7; e2300051; PMCID PMC11102808; 10.1002/bies.202300051
- Varshavsky, Alexander and Finley, Daniel, et el. (2023) Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system; EMBO Journal; Vol. 42; No. 11; Art. No. e114222; 10.15252/embj.2023114222
- Kim, Bong Heon and Kim, Min Kyung, et el. (2022) Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates; Proceedings of the National Academy of Sciences of the United States of America; Vol. 119; No. 31; Art. No. e2209597119; PMCID PMC9351520; 10.1073/pnas.2209597119
- Chen, Shun-Jia and Kim, Leehyeon, et el. (2021) Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 118; No. 43; Art. No. e2115430118; PMCID PMC8639330; 10.1073/pnas.2115430118
- Vu, Tri T. M. and Mitchell, Dylan C., et el. (2020) The Arg/N-degron pathway targets transcription factors and regulates specific genes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 117; No. 49; 31094-31104; PMCID PMC7733807; 10.1073/pnas.2020124117
- Vu, Tri T. M. and Varshavsky, Alexander (2020) The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway; Biochemistry; Vol. 59; No. 30; 2796-2812; PMCID PMC7669821; 10.1021/acs.biochem.0c00514
- Dong, Cheng and Chen, Shun-Jia, et el. (2020) Recognition of nonproline N-terminal residues by the Pro/N-degron pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 117; No. 25; 14158-14167; PMCID PMC7322002; 10.1073/pnas.2007085117
- Oh, Jang-Hyun and Hyun, Ju-Yeon, et el. (2020) Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling; Proceedings of the National Academy of Sciences of the United States of America; Vol. 117; No. 20; 10778-10788; PMCID PMC7245096; 10.1073/pnas.2003043117
- Chen, Shun-Jia and Melnykov, Artem, et el. (2020) Evolution of Substrates and Components of the Pro/N-Degron Pathway; Biochemistry; Vol. 59; No. 4; 582-593; PMCID PMC7286083; 10.1021/acs.biochem.9b00953
- Melnykov, Artem and Chen, Shun-Jia, et el. (2019) Gid10 as an alternative N-recognin of the Pro/N-degron pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 32; 15914-15923; PMCID PMC6689949; 10.1073/pnas.1908304116
- Varshavsky, Alexander (2019) On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 22; 10773-10782; PMCID PMC6561186; 10.1073/pnas.1904709116
- Varshavsky, Alexander (2019) N-degron and C-degron pathways of protein degradation; Proceedings of the National Academy of Sciences of the United States of America; Vol. 116; No. 2; 358-366; PMCID PMC6329975; 10.1073/pnas.1816596116
- Kim, Jeong-Mok and Seok, Ok-Hee, et el. (2018) Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway; Science; Vol. 362; No. 6418; Art. No. eaat0174; PMCID PMC6551516; 10.1126/science.aat0174
- Dougan, David A. and Varshavsky, Alexander (2018) Understanding the Pro/N-end rule pathway; Nature Chemical Biology; Vol. 14; No. 5; 415-416; 10.1038/s41589-018-0045-0
- Oh, Jang-Hyun and Chen, Shun-Jia, et el. (2017) A reference-based protein degradation assay without global translation inhibitors; Journal of Biological Chemistry; Vol. 292; No. 52; 21457-21465; PMCID PMC5766948; 10.1074/jbc.M117.814236
- Varshavsky, Alexander (2017) The Ubiquitin System, Autophagy, and Regulated Protein Degradation; Annual Review of Biochemistry; Vol. 86; 123-128; 10.1146/annurev-biochem-061516-044859
- Oh, Jang-Hyun and Hyun, Ju-Yeon, et el. (2017) Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 114; No. 22; E4370-E4379; PMCID PMC5465900; 10.1073/pnas.1705898114
- Chen, Shun-Jia and Wu, Xia, et el. (2017) An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes; Science; Vol. 355; No. 6323; Art. No. eaal3655; PMCID PMC5457285; 10.1126/science.aal3655
- Wadas, Brandon and Piatkov, Konstantin, et el. (2016) Analyzing N-terminal Arginylation Through the Use of Peptide Arrays and Degradation Assays; Journal of Biological Chemistry; Vol. 291; No. 40; Art. No. 20976; PMCID PMC5076509; 10.1074/jbc.M116.747956
- Wadas, Brandon and Borjigin, Jimo, et el. (2016) Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway; Journal of Biological Chemistry; Vol. 291; No. 33; 17178-17196; PMCID PMC5016120; 10.1074/jbc.M116.734640
- Liu, Yu-Jiao and Liu, Chao, et el. (2016) Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway; Journal of Biological Chemistry; Vol. 291; No. 14; 7426-7438; PMCID PMC4817174; 10.1074/jbc.M116.714964
- Piatkov, Konstantin and Vu, Tri, et el. (2015) Formyl-methionine as a degradation signal at the N-termini of bacterial proteins; Microbial Cell; Vol. 2; No. 10; 376-393; PMCID PMC4745127; 10.15698/mic2015.10.231
- Park, Sang-Eun and Kim, Jeong-Mok, et el. (2015) Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway; Science; Vol. 347; No. 6227; 1249-1252; PMCID PMC4748709; 10.1126/science.aaa3844
- Brower, Christopher S. and Rosen, Connor E., et el. (2014) Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 46; E4936-E4945; PMCID PMC4246273; 10.1073/pnas.1419587111
- Varshavsky, Alexander (2014) Discovery of the Biology of the Ubiquitin System; JAMA : the journal of the American Medical Association; Vol. 311; No. 19; 1969-1970; 10.1001/jama.2014.5549
- Piatkov, Konstantin I. and Oh, Jang-Hyun, et el. (2014) Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 111; No. 9; E817-E826; PMCID PMC3948289; 10.1073/pnas.1401639111
- Kim, Heon-Ki and Kim, Ryu-Ryun, et el. (2014) The N-Terminal Methionine of Cellular Proteins as a Degradation Signal; Cell; Vol. 156; No. 1; 158-169; PMCID PMC3988316; 10.1016/j.cell.2013.11.031
- Piatkov, Konstantin and Graciet, Emmanuelle, et el. (2013) Ubiquitin Reference Technique and Its Use in Ubiquitin-Lacking Prokaryotes; PLoS ONE; Vol. 8; No. 6; Art. No. e67952; PMCID PMC3692480; 10.1371/journal.pone.0067952
- Shemorry, Anna and Hwang, Cheol-Sang, et el. (2013) Control of Protein Quality and Stoichiometries by N-Terminal
Acetylation and the N-End Rule Pathway; Molecular Cell; Vol. 50; No. 4; 540-551; PMCID PMC3665649; 10.1016/j.molcel.2013.03.018
- Brower, Christopher S. and Piatkov, Konstantin I., et el. (2013) Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway; Molecular Cell; Vol. 50; No. 2; 161-171; PMCID PMC3640747; 10.1016/j.molcel.2013.02.009
- Piatkov, Konstantin I. and Colnaghi, Luca, et el. (2012) The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway; Molecular Cell; Vol. 48; No. 6; 926-933; PMCID PMC3889152; 10.1016/j.molcel.2012.10.012
- Varshavsky, Alexander (2012) Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis; Protein Science; Vol. 21; No. 11; PMCID PMC3527701; 10.1002/pro.2148
- Piatkov, Konstantin I. and Brower, Christopher S., et el. (2012) The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments; Proceedings of the National Academy of Sciences of the United States of America; Vol. 109; No. 27; E1839-E1847; PMCID PMC3390858; 10.1073/pnas.1207786109
- Varshavsky, Alexander (2012) The Ubiquitin System, an Immense Realm; Annual Review of Biochemistry; Vol. 81; 167-176; 10.1146/annurev-biochem-051910-094049
- Hwang, Cheol-Sang and Sukalo, Maja, et el. (2011) Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome; PLoS ONE; Vol. 6; No. 9; Art.No. e24925; PMCID PMC3172311; 10.1371/journal.pone.0024925
- Varshavsky, Alexander (2011) The N-end rule pathway and regulation by proteolysis; Protein Science; Vol. 20; No. 8; 1298-1345; PMCID PMC3189519; 10.1002/pro.666
- Hwang, Cheol-Sang and Shemorry, Anna, et el. (2010) The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases; Nature Cell Biology; Vol. 12; No. 12; 1177-1185; PMCID PMC3003441; 10.1038/ncb2121
- Brower, Christopher S. and Veiga, Lucia, et el. (2010) Mouse Dfa Is a Repressor of TATA-box Promoters and Interacts with the Abt1 Activator of Basal Transcription; Journal of Biological Chemistry; Vol. 285; No. 22; 17218-17234; PMCID PMC2878062; 10.1074/jbc.M110.118638
- Hwang, Cheol-Sang and Shemorry, Anna, et el. (2010) N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals; Science; Vol. 327; No. 5968; 973-977; PMCID PMC4259118; 10.1126/science.1183147
- Brower, Christopher S. and Varshavsky, Alexander (2009) Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations; PLoS ONE; Vol. 4; No. 11; Art. No. e7757; PMCID PMC2773024; 10.1371/journal.pone.0007757
- Graciet, Emmanuelle and Walter, Franziska, et el. (2009) The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 32; 13618-13623; PMCID PMC2726413; 10.1073/pnas.0906404106
- Wang, Haiqing and Piatkov, Konstantin I., et el. (2009) Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway; Molecular Cell; Vol. 34; No. 6; 686-695; PMCID PMC2749074; 10.1016/j.molcel.2009.04.032
- Hwang, Cheol-Sang and Shemorry, Anna, et el. (2009) Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase; Proceedings of the National Academy of Sciences of the United States of America; Vol. 106; No. 7; 2142-2147; PMCID PMC2650122; 10.1073/pnas.0812316106
- Varshavsky, Alexander (2008) Discovery of cellular regulation by protein degradation; Journal of Biological Chemistry; Vol. 283; No. 50; 34469-34489; PMCID PMC3259866; 10.1074/jbc.X800009200
- Hwang, Cheol-Sang and Varshavsky, Alexander (2008) Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 105; No. 49; 19188-19193; PMCID PMC2614737; 10.1073/pnas.0808891105
- Varshavsky, Alexander (2008) The N-end rule at atomic resolution; Nature Structural & Molecular Biology; Vol. 15; No. 12; 1238-1240; 10.1038/nsmb1208-1238
- Xia, Zanxian and Turner, Glenn C., et el. (2008) Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter; Journal of Biological Chemistry; Vol. 283; No. 43; 28958-28968; PMCID PMC2570885; 10.1074/jbc.M803980200
- Xia, Zanxian and Webster, Ailsa, et el. (2008) Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway; Journal of Biological Chemistry; Vol. 283; No. 35; 24011-24028; PMCID PMC2527112; 10.1074/jbc.M802583200
- Connor, Rebecca E. and Piatkov, Konstantin, et el. (2008) Enzymatic N-terminal Addition of Noncanonical Amino Acids to Peptides and Proteins; ChemBioChem; Vol. 9; No. 3; 366-369; 10.1002/cbic.200700605
- Hu, Rong-Gui and Wang, Haiqing, et el. (2008) The N-end rule pathway is a sensor of heme; Proceedings of the National Academy of Sciences of the United States of America; Vol. 105; No. 1; 76-81; PMCID PMC2224235; 10.1073/pnas.0710568105
- Schnupf, Pamela and Zhou, Jianmin, et el. (2007) Listeriolysin O Secreted by Listeria monocytogenes into the Host Cell Cytosol Is Degraded by the N-End Rule Pathway; Infection and Immunity; Vol. 75; No. 11; 5135-5147; PMCID PMC2168281; 10.1128/IAI.00164-07
- Varshavsky, Alexander (2007) Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy; Proceedings of the National Academy of Sciences of the United States of America; Vol. 104; No. 38; 14935-14940; PMCID PMC1986591; 10.1073/pnas.0706546104
- Tasaki, Takafumi and Sohr, Reinhard, et el. (2007) Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems; Journal of Biological Chemistry; Vol. 282; No. 25; 18510-18520; 10.1074/jbc.M701894200
- Hu, Rong-Gui and Brower, Christopher S., et el. (2006) Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms; Journal of Biological Chemistry; Vol. 281; No. 43; 32559-32573; 10.1074/jbc.M604355200
- An, Jee Young and Seo, Jai Wha, et el. (2006) Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 16; 6212-6217; PMCID PMC1458857; 10.1073/pnas.0601700103
- Graciet, Emmanuelle and Hu, Rong-Gui, et el. (2006) Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen; Proceedings of the National Academy of Sciences of the United States of America; Vol. 103; No. 9; 3078-3083; PMCID PMC1413915; 10.1073/pnas.0511224103
- Zenker, Martin and Varshavsky, Alexander (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome); Nature Genetics; Vol. 37; No. 12; 1345-1350; 10.1038/ng1681
- Hu, Rong-Gui and Sheng, Jun, et el. (2005) The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators; Nature; Vol. 437; No. 7061; 981-989; 10.1038/nature04027
- Tasaki, Takafumi and Mulder, Lubbertus C. F., et el. (2005) A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons; Molecular and Cellular Biology; Vol. 25; No. 16; 7120-7136; PMCID PMC1190250; 10.1128/MCB.25.16.7120-7136.2005
- Yin, Jinhu and Kwon, Yong Tae, et el. (2004) RECQL4, mutated in the Rothmund–Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway; Human Molecular Genetics; Vol. 13; No. 20; 2421-2430; 10.1093/hmg/ddh269
- Kwon, Yong Tae and Xia, Zanxian, et el. (2003) Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway; Molecular and Cellular Biology; Vol. 23; No. 22; 8255-8271; PMCID PMC262401; 10.1128/MCB.23.22.8255-8271.2003
- Varshavsky, Alexander (2003) The N-end rule and regulation of apoptosis; Nature Cell Biology; Vol. 5; No. 5; 373-376; 10.1038/ncb0503-373
- Xie, Youming and Varshavsky, Alexander (2002) UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis; Nature Cell Biology; Vol. 4; No. 12; 1003-1007; 10.1038/ncb889
- Du, Fangyong and Navarro-Garcia, Federico, et el. (2002) Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain; Proceedings of the National Academy of Sciences of the United States of America; Vol. 99; No. 22; 14110-14115; PMCID PMC137845; 10.1073/pnas.172527399
- Kwon, Yong Tae and Kashina, Anna S., et el. (2002) An Essential Role of N-Terminal Arginylation in Cardiovascular Development; Science; Vol. 297; No. 5578; 96-99; 10.1126/science.1069531
- Kwon, Yong Tae and Xia, Zanxian, et el. (2001) Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway; Molecular and Cellular Biology; Vol. 21; No. 23; 8007-8021; PMCID PMC99968; 10.1128/MCB.21.23.8007-8021.2001
- Rao, Hai and Uhlmann, Frank, et el. (2001) Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability; Nature; Vol. 410; No. 6831; 955; 10.1038/35073627
- Xie, Youming and Varshavsky, Alexander (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit; Proceedings of the National Academy of Sciences of the United States of America; Vol. 98; No. 6; 3056-3061; PMCID PMC30606; 10.1073/pnas.071022298
- Hershko, Avram and Ciechanover, Aaron, et el. (2000) The ubiquitin system; Nature Medicine; Vol. 6; No. 10; 1073-1081; 10.1038/80384
- Turner, Glenn C. and Varshavsky, Alexander (2000) Detecting and Measuring Cotranslational Protein Degradation in Vivo; Science; Vol. 289; No. 5487; 2117-2120; 10.1126/science.289.5487.2117
- Varshavsky, Alexander and Turner, Glenn, et el. (2000) The Ubiquitin System and the N-End Rule Pathway; Biological Chemistry; Vol. 381; No. 9-10; 779-789; 10.1515/BC.2000.101
- Kwon, Yong Tae and Balogh, Seth A., et el. (2000) Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway; Molecular and Cellular Biology; Vol. 20; No. 11; 4135-4148; PMCID PMC85783
- Turner, Glenn C. and Du, Fangyong, et el. (2000) Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway; Nature; Vol. 405; No. 6786; 579; 10.1038/35014629
- Davydov, Ilia V. and Varshavsky, Alexander (2000) RGS4 is arginylated and degraded by the N-end rule pathway in vitro; Journal of Biological Chemistry; Vol. 275; No. 30; 22931-22941; 10.1074/jbc.M001605200
- Xie, Youming and Varshavsky, Alexander (2000) Physical association of ubiquitin ligases and the 26S proteasome; Proceedings of the National Academy of Sciences of the United States of America; Vol. 97; No. 6; 2497-2502; PMCID PMC15957; 10.1073/pnas.060025497
- Kwon, Yong Tae and Lévy, Frédéric, et el. (1999) Bivalent Inhibitor of the N-end Rule Pathway; Journal of Biological Chemistry; Vol. 274; No. 25; 18135-18139; 10.1074/jbc.274.25.18135
- Dünnwald, Martin and Varshavsky, Alexander, et el. (1999) Detection of Transient In Vivo Interactions between Substrate and Transporter during Protein Translocation into the Endoplasmic Reticulum; Molecular Biology of the Cell; Vol. 10; No. 2; 329-344; PMCID PMC25172; 10.1091/mbc.10.2.329
- Kwon, Yong Tae and Kashina, Anna S., et el. (1999) Alternative Splicing Results in Differential Expression, Activity, and Localization of the Two Forms of Arginyl-tRNA-Protein Transferase, a Component of the N-End Rule Pathway; Molecular and Cellular Biology; Vol. 19; No. 1; 182-193; PMCID PMC83877; 10.1128/mcb.19.1.182
- Varshavsky, Alexander (1999) Recent studies of the ubiquitin system and the N-end rule pathway; Harvey lectures; Vol. 96; 93-116
- Kwon, Yong Tae and Reiss, Yuval, et el. (1998) The mouse and human genes encoding the recognition component of the N-end rule pathway; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 14; 7898-7903; PMCID PMC20901; 10.1073/pnas.95.14.7898
- Varshavsky, Alexander (1998) Codominant interference, antieffectors, and multitarget drugs; Proceedings of the National Academy of Sciences of the United States of America; Vol. 95; No. 5; 2094-2099; PMCID PMC19261
- Ramos, Paula C. and Höckendorff, Jörg, et el. (1998) Ump1p Is Required for Proper Maturation of the 20S Proteasome and Becomes Its Substrate upon Completion of the Assembly; Cell; Vol. 92; No. 4; 489-499; 10.1016/s0092-8674(00)80942-3
- Byrd, Christopher and Turner, Glenn C., et el. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor; EMBO Journal; Vol. 17; No. 1; 269-277; PMCID PMC1170377; 10.1093/emboj/17.1.269
- Varshavsky, Alexander (1997) The ubiquitin system; Trends in Biochemical Sciences; Vol. 22; No. 10; 383-387; 10.1016/s0968-0004(97)01122-5
- Varshavsky, Alexander (1997) The N-end rule pathway of protein degradation; Genes to Cells; Vol. 2; No. 1; 13-28; 10.1046/j.1365-2443.1997.1020301.x
- Grigoryev, Sergei and Stewart, Albert E., et el. (1996) A Mouse Amidase Specific for N-terminal Asparagine: the gene, the enzyme, and their function in the N-end rule pathway; Journal of Biological Chemistry; Vol. 271; No. 45; 28521-28532; 10.1074/jbc.271.45.28521
- Varshavsky, Alexander (1996) The N-end rule: Functions, mysteries, uses; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 22; 12142-12149; PMCID PMC37957; 10.1073/pnas.93.22.12142
- Ghislain, Michel and Dohmen, R. Jürgen, et el. (1996) Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae; EMBO Journal; Vol. 15; No. 18; 4884-4899; PMCID PMC452226; 10.1002/j.1460-2075.1996.tb00869.x
- Lévy, Frédéric and Johnsson, Nils, et el. (1996) Using ubiquitin to follow the metabolic fate of a protein; Proceedings of the National Academy of Sciences of the United States of America; Vol. 93; No. 10; 4907-4912; PMCID PMC39378; 10.1073/pnas.93.10.4907
- Dohmen, R. Jürgen and Stappen, Reiner, et el. (1995) An Essential Yeast Gene Encoding a Homolog of Ubiquitin-activating Enzyme; Journal of Biological Chemistry; Vol. 270; No. 30; 18099-18109; 10.1074/jbc.270.30.18099
- Baker, Rohan T. and Varshavsky, Alexander (1995) Yeast N-terminal Amidase: a new enzyme and component of the N-end rule pathway; Journal of Biological Chemistry; Vol. 270; No. 20; 12065-12074; 10.1074/jbc.270.20.12065
- Varshavsky, Alexander (1995) Codominance and toxins: A path to drugs of nearly unlimited selectivity; Proceedings of the National Academy of Sciences of the United States of America; Vol. 92; No. 9; 3663-3667; PMCID PMC42021; 10.1073/pnas.92.9.3663
- Johnston, Jennifer A. and Johnson, Erica S., et el. (1995) Methotrexate Inhibits Proteolysis of Dihydrofolate Reductase by the N-end Rule Pathway; Journal of Biological Chemistry; Vol. 270; No. 14; 8172-8178; 10.1074/jbc.270.14.8172
- Varshavsky, A. J. (1995) The N-end Rule; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 60; 461-478; 10.1101/sqb.1995.060.01.051
- Johnsson, Nils and Varshavsky, Alexander (1994) Split ubiquitin as a sensor of protein interactions in vivo; Proceedings of the National Academy of Sciences of the United States of America; Vol. 91; No. 22; 10340-10344; PMCID PMC45015; 10.1073/pnas.91.22.10340
- Madura, Kiran and Varshavsky, Alexander (1994) Degradation of Gα by the N-End Rule Pathway; Science; Vol. 265; No. 5177; 1454-1458; 10.1126/science.8073290
- Johnsson, Nils and Varshavsky, Alexander (1994) Ubiquitin-assisted dissection of protein transport across membranes; EMBO Journal; Vol. 13; No. 11; 2686-2698; PMCID PMC395143; 10.1002/j.1460-2075.1994.tb06559.x
- Dohmen, R. Jürgen and Wu, Peipei, et el. (1994) Heat-Inducible Degron: A Method for Constructing Temperature-Sensitive Mutants; Science; Vol. 263; No. 5151; 1273-1276; 10.1126/science.8122109
- Ota, Irene M. and Varshavsky, Alexander (1993) A yeast protein similar to bacterial two-component regulators; Science; Vol. 262; No. 5133; 566-569; 10.1126/science.8211183
- Shrader, Thomas E. and Tobias, John W., et el. (1993) The N-End Rule in Escherichia coli: Cloning and Analysis of
the Leucyl, Phenylalanyl-tRNA-Protein Transferase Gene aat; Journal of Bacteriology; Vol. 175; No. 14; 4364-4374; PMCID PMC204876; 10.1128/jb.175.14.4364-4374.1993
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- Solomon, Mark J. and Varshavsky, Alexander (1985) Formaldehyde-mediated DNA-protein crosslinking: A probe for in vivo chromatin structures; Proceedings of the National Academy of Sciences of the United States of America; Vol. 82; No. 19; 6470-6474; PMCID PMC390738; 10.1073/pnas.82.19.6470
- Barsoum, James and Varshavsky, Alexander (1985) Preferential localization of variant nucleosomes near the 5'-end of the mouse dihydrofolate reductase gene; Journal of Biological Chemistry; Vol. 260; No. 12; 7688-7697; 10.1016/s0021-9258(17)39663-1
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- Strauss, François and Varshavsky, Alexander (1984) A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome; Cell; Vol. 37; No. 3; 889-901; 10.1016/0092-8674(84)90424-0
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- Varshavsky, Alexander (1983) Do stalled replication forks synthesize a specific alarmone?; Journal of Theoretical Biology; Vol. 105; No. 4; 707-714; 10.1016/0022-5193(83)90228-x
- Snapka, Robert M. and Varshavsky, Alexander (1983) Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea; Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 24; 7533-7537; PMCID PMC389986; 10.1073/pnas.80.24.7533
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- Varshavsky, Alexander (1983) Diadenosine 5′, 5′′′-P¹, P⁴-tetraphosphate: a pleiotropically acting alarmone?; Cell; Vol. 34; No. 3; 711-712; 10.1016/0092-8674(83)90526-3
- Barsoum, James and Varshavsky, Alexander (1983) Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes; Proceedings of the National Academy of Sciences of the United States of America; Vol. 80; No. 17; 5330-5334; PMCID PMC384249; 10.1073/pnas.80.17.5330
- Swerdlow, Paul S. and Varshavsky, Alexander (1983) Affinity of HMG17 for a mononucleosome is not influenced by the presence of ubiquitin-H2A semihistone but strongly depends on DNA fragment size; Nucleic Acids Research; Vol. 11; No. 2; 387-401; PMCID PMC325721; 10.1093/nar/11.2.387
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- Varshavsky, A. and Levinger, L., et el. (1983) Cellular and SV40 Chromatin: Replication, Segregation, Ubiqiritination, Nuclease-hypersensitive Sites, HMG-containing Nueleosomes, and Heterochromatin-specific Protein; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 47; 511-528; 10.1101/sqb.1983.047.01.061
- Levinger, Louis and Varshavsky, Alexander (1982) Protein D1 preferentially binds A+T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A+T-rich satellite DNA; Proceedings of the National Academy of Sciences of the United States of America; Vol. 79; No. 23; 7152-7156; PMCID PMC347296; 10.1073/pnas.79.23.7152
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- Levinger, Louis and Varshavsky, Alexander (1982) Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the drosophila genome; Cell; Vol. 28; No. 2; 375-385; 10.1016/0092-8674(82)90355-5
- Levinger, Louis and Varshavsky, Alexander (1981) Heat-shock proteins of Drosophila are associated with nuclease-resistant, high-salt-resistant nuclear structures; Journal of Cell Biology; Vol. 90; No. 3; 793-796; PMCID PMC2111893; 10.1083/jcb.90.3.793
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- Varshavsky, Alexander (1981) On the possibility of metabolic control of replicon "misfiring": Relationship to emergence of malignant phenotypes in mammalian cell lineages; Proceedings of the National Academy of Sciences of the United States of America; Vol. 78; No. 6; 3673-3677; PMCID PMC319633; 10.1073/pnas.78.6.3673
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- Levinger, Louis and Varshavsky, Alexander (1980) High-resolution fractionation of nucleosomes: minor particles, "whiskers," and separation of mononucleosomes containing and lacking A24 semihistone; Proceedings of the National Academy of Sciences of the United States of America; Vol. 77; No. 6; 3244-3248; PMCID PMC349591; 10.1073/pnas.77.6.3244
- Sundin, Olof and Varshavsky, Alexander (1979) Staphylococcal nuclease makes a single non-random cut in the simian virus 40 viral minichromosome; Journal of Molecular Biology; Vol. 132; No. 3; 535-546; 10.1016/0022-2836(79)90274-2
- Varshavsky, Alexander J. and Sundin, Olof, et el. (1979) A stretch of "late" SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomes; Cell; Vol. 16; No. 2; 453-466; 10.1016/0092-8674(79)90021-7
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- Varshavsky, A. J. and Bakayev, V. V., et el. (1978) On the Structure of Eukaryotic, Prokaryotic, and Viral Chromatin; Cold Spring Harbor Symposia on Quantitative Biology; Vol. 42; No. 1; 457-473; 10.1101/sqb.1978.042.01.049
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- Varshavsky, A. J. and Georgiev, G. P. (1976) Free DNA stretches in histone H1-depleted chromatin and their possible relation to chromomere structure; Molecular Biology Reports; Vol. 3; No. 1; 27-38; 10.1007/bf00357206
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- Varshavsky, A. J. and Bakayev, V. V. (1975) Studies on chromatin. IV. Evidence for a toroidal shape of chromatin subunits; Molecular Biology Reports; Vol. 2; No. 3; 247-254; 10.1007/bf00356995
- Varshavsky, A. J. and Georgiev, G. P. (1975) Studies on chromatin. V. A model for the structure of chromatin subunit; Molecular Biology Reports; Vol. 2; No. 3; 255-262; 10.1007/bf00356996
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- Varshavsky, A. J. and Ilyin, Yu. V., et el. (1973) Long molecules of free DNA in the sheared chromatin preparation; Molecular Biology Reports; Vol. 1; No. 4; 201-207; 10.1007/bf00357642
- Varshavsky, Alexander J. and Georgiev, Georgii P. (1973) Redistribution of histones during unfolding of chromosomal DNA; Molecular Biology Reports; Vol. 1; No. 3; 143-148; 10.1007/bf00357154
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